Fibrates, wanda aka fi sani da masu amfani da sinadarin fibric acid, sune nau'i na kwayoyin da ke rage yawan kwayoyin da ke da ikon yin tasiri ga dukkan fannonin bayanin ku na lipid.
Hanyar da ke fibrates ƙananan cholesterol shine hadaddun. Fibrates ta kunna wani furotin da ake kira adabin mai karba mai haɓakaccen peroxisome-activated alpha (PPAR-alpha). Wannan furotin zai iya aiki wani enzyme, lipoprotein lipase, wanda ya rage adadin apolipoprotein C-III cikin jiki.
Ƙarshe, wannan yana haifar da raguwa na VLDL da triglycerides kuma yana ƙara ƙaddamar da lipids. Fibrates kuma ya karu a matakan HDL ta kara yawan adadin apolipoprotein AI da A-II a cikin jiki.
A halin yanzu akwai wasu maganin fibrate biyu da aka yarda don amfani da Abincin da Drug Administration (FDA) a Amurka:
- Gemfibrozil (Lopid)
- Ƙaramar (Tricor)
Fibrates suna da yawa a sanannun ƙaddamar da triglycerides da kuma kara HDL cholesterol. Duk da haka, za su iya rinjayar duk bangarori na labarun ka. Gaba ɗaya, fibrates iya:
- Ƙananan matakan LDL na cholesterol da kashi 5 zuwa kashi 20 cikin 100.
- Ƙara yawan cholesterol na HDL ta ko'ina tsakanin kashi 10 zuwa kashi 35.
- Ka rage matakan triglyceride da kashi 20 zuwa kashi 50.
Don inganta yadda ya kamata, za a iya amfani da fibrates kadai ko a hade tare da wasu magunguna masu tsada, irin su statins ko omega-3 acid fat.
Ta Yaya Ya Kamata Ka Dauki Fita
Ya kamata ka dauki fibrate daidai kamar yadda aka ba ka ta hanyar kiwon lafiyarka kuma ya kamata ka tabbata kada ka rasa kowane asara. Dukkan magungunan fibrate suna samuwa a cikin nau'i na kwamfutar hannu kuma suna bakin baki. Kodayake zaka iya daukar nau'in fibrates biyu tare ko ba tare da abinci ba; duk da haka, binciken ya nuna cewa shan fibrate, gemfibrozil, tare da abinci yana taimakawa wajen kara yawan shayarwa.
Har ila yau, ya kamata ka tabbata kada ka rasa duk wani alƙawarinka tare da mai bada sabis na kiwon lafiya, tun da yake yana son saka idanu ko magani yana aiki a gare ka. Mai bada sabis na kiwon lafiya na iya buƙatar yin gyare-gyare a farfadowar kawancin ka, dangane da yadda kake amsa maganin miyagun ƙwayoyi. Duk da yake shan fibrates - ko wani sauran maganin kutsawa - ya kamata ka kasance a biye bayan cin abinci don rage yawan cholesterol da triglycerides.
Shin Akwai Hanyoyin Hanya Kana Ya Kamata Duba?
Ko da yake fibrates suna da haƙuri a tsakanin mutanen da suke daukar su, za ku iya samun wasu sakamako masu illa daga karbar su, Abubuwan da suka faru na yau da kullum sun hada da fuskantar matsalolin gastrointestinal, irin su tashin zuciya, zawo, da kuma ciwo na ciki. Wadannan sakamako masu illa ne mafi sauƙi kuma, a mafi yawancin lokuta, tafi bayan farawa fibrate.
A wasu lokuta, fibrates na iya kara yawan mahaukaciyar hanta, don haka baya ga lipids ɗinka, mai bada sabis na kiwon lafiya zai kuma lura da hawan enzymes a lokaci-lokaci. Idan kana da cututtuka, za ka bari mai kula da lafiyarka ya san, tun da akwai ƙananan haɗari na tasowa daga gallstones yayinda kake daukar fibrate. Fibrates na iya haifar da yanayin da ake kira rhabdomyolysis.
Ko da yake rare, haɗarin tasowa wannan yanayin yayin shan fibrates yana ƙaruwa idan kana shan wasu magunguna tare da fibrate ko samun wasu likita yanayin.
Fibrates zai iya ƙara yawan yiwuwar fuskantar jinin idan kuna shan jini, irin su Coumadin ( warfarin ). Saboda wannan, mai bada sabis na kiwon lafiya zai iya daidaita ƙimarku yayin shan fibrates.
Hanyoyin da ke fama da fibrates sun kasance mai sauƙi, amma ya kamata a kai ga kula da lafiyar ku idan sun zama damuwa ko kuma na cigaba da lokaci. Ya kamata ka sanar da asusunka na lafiyar duk magunguna da kake dauka - ciki har da duk kayan daji ko kayan kan-da-counter - ko yanayin kiwon lafiya wanda kake da shi don ya iya duba ka a yayin da kake farfado.
Sources:
> Dipiro JT, Talbert RL. Pharmacotherapy: A Approach Pathophysiological, 9th ed 2014.
Malloy MJ, Kane JP. Agents Used a Dyslipidemia. A cikin: Katzung BG, Trevor AJ.eds. Basic & Clinical Pharmacology, 13th . New York, NY: McGraw-Hill; 2015.