Shin Diarrhea a IBS ya shafi Bile Acid Malbsorption Matsala?
Don neman zurfin fahimtar abubuwan da ke haifar da cututtukan zuciya (IBS), wasu masu bincike sun mayar da hankalinsu ga wani yanayin da aka sani da malassorption malaika (I-BAM) na idiopathic bile acid.
Mene ne I-BAM?
Bile acid abu ne da aka samar da hanta da kuma adana a cikin gallbladder . Bile acid taimaka wajen aiwatar da kwayar cutar, wanda ke faruwa a cikin ƙananan hanji.
Yawancin lokaci, ƙwayar bile zata shafe ta da ƙananan hanji kuma ya koma cikin hanta don sake yin amfani da shi kuma ana amfani dashi kusan sau 10 a kowace rana. Sai kawai ƙananan adadin bile acid (kashi 5 cikin dari) yakan wuce zuwa ga mallaka, babban hanji .
Amma idan adadin bile acid da yawa zasu iya shiga cikin babban hanji, zasu zuga kwayoyin halitta, wanda zai haifar da sako-sako, tsabta da ruwa da zawo. Wannan yanayin ana kiransa malabsorption mai bile acid (BAM). Idan ba tare da wani ciwo na gastrointestinal da kuma rauni ba, ana iya cewa malabsorption shine nau'i na 2 BAM, wanda ba a san shi ba a matsayin idiopathic ko BAM na farko (I-BAM ko P-BAM).
I-BAM an yi la'akari da shi azaman yanayi mai wuya. Duk da haka, binciken bincike ya gano cewa kimanin kashi 25 zuwa 30 na marasa lafiya da irin kwayoyin cutar IBS-D da aka gwada su tabbatacce ga I-BAM ta amfani da 75SeHCAT scan.
A wani ɓangare na wannan bita, bayanai sun nuna cewa marasa lafiya da aka ba da magungunan maganin magungunan bile acid wadanda aka danganta da matakin malabsorption kamar yadda kwayar cutar ta nukiliya ta auna ta nuna alamar cigaba.
Masu bincike sun bayyana cewa rashin ganewar asalin I-BAM saboda jahilci game da yaduwa da kuma rashin samun damar dubawa (ba a samuwa a Amurka) na iya haifar da marasa lafiya na IBS-D ba karɓar magani mai dacewa ba .
Wata Mawuyacciyar Tsira
Masu bincike sunyi ƙoƙari su ƙara fahimtar abin da zai iya kasancewa a cikin wannan matsala na maganin malaysorption.
Mutum mai yiwuwa shi ne wani ƙwayar ƙwayar (ƙwayar hanzarin zuciya), FGF19, wanda ke da alhakin sarrafa ikon samar da bile acid. Wataƙila ƙananan matakan wannan hormone suna haifar da yawan bile acid wanda ya haifar da lalata cikin babban hanji. Bincike yana gudana don fahimtar wannan dysfunction mafi kyau, tare da begen cewa zai iya haifar da magunguna da ke fuskantar matsalar.
Layin Ƙasa
Kamar yadda yake da muhimmanci kamar lambobi 25 zuwa 30, yana da muhimmanci mu lura cewa wannan bangare na bincike ya nuna cewa ɗayan ƙungiyar masu bincike ne za su jagoranta. Kuma, da rashin alheri, yayin da 75SeHCAT scan ba a samuwa a Amurka, ba kamar idan akwai gwajin jini mai sauri don gano idan IBS-D na ainihin I-BAM. Duk da haka, idan kun kasance da kwaskwarima, ɗakunan ruwa su zama ɓangare na alamar alamar alamarku, kuna iya magana da likitan ku don ganin ko za ku zama dan takara don gwaji na magunguna da ake amfani dasu don biyan BAM.
Sources:
Pattni, S. & Walters, J. "Ci gaba da sauri a fahimtar biyan acid malabsorption" Bulletin Jarida na Birtaniya 2009 92: 79-93.
Walters, J. "Magana da ƙananan bile acid cututtuka: yin ganewar asali da kuma fahimtar cutar" Binciken Kasuwanci 2010 4: 561-567.
Wedlake, L., et.al. "Binciken na yau da kullum: ƙaddamar da malassorption na asibiti na biyan acid kamar yadda bincikar SeHCAT ta bincikar a cikin marasa lafiya da cututtukan da suka kamu da ciwon jini" Abincin Pharmacology da Therapeutics 2009 30: 707-717.
Walters, J. "Magana da ƙananan bile acid cututtuka: yin ganewar asali da kuma fahimtar cutar" Binciken Kasuwanci 2010 4: 561-567.