IBS-D zai iya zama ta hanyar matsala tare da Bile acid
Biwo acid zazzabin (BAD) wani yanayin ne wanda ba a magance shi a cikin tsarin narkewa ba , wanda ya haifar da alamar cututtuka na ciwo mai tsanani. Wannan yanayin kuma za a iya san shi kamar bile acid malabsorption (BAM). Duk da haka, bincike ya nuna cewa yanayin bazai kasancewa bane saboda malabsorption.
Masu bincike a wannan yanki sunyi imanin cewa BAD ba wani abu ba ne kamar yadda aka taɓa tunaninta.
Har ila yau, sun yarda cewa BAD wata cuta ne da ba a bincikar da shi ba wanda ya kamata a yi la'akari da duk wanda ke fama da ciwo mai ƙyama daga rashin sani - musamman ma mutanen da ke da alamun cututtukan cututtukan zuciya (IBS-D) ko kuma aikin zawo . Matsalar tare da wannan ganewar asali shi ne cewa zai iya hana mutane daga samun magani mai kyau.
Bayani
Don mafi kyau fahimtar BAM, yana taimakawa wajen koyon yadda za a yi narkewa. Ana samar da Bile acid daga hanta da kuma adana a cikin gallbladder. Lokacin da ku ci abincin da ke dauke da mai, ana satar da wadannan kwayoyin cikin ƙananan hanji don haka za a iya rushe fatsun da kuma tunawa cikin jiki.
An kuma bi da bile acid a matakin ƙananan hanji a cikin hanta don sake sakewa idan an buƙata. Yawanci kawai ƙananan adadin wadannan kwayoyin sun sa hanyarsu cikin babban hanji.
Duk da haka, lokacin da BAD ya kasance, yawan ƙwayar bile acid mai yawa ya shiga cikin babban hanji .
Wannan yana haifar da ƙara yawan kyawawan ruwa, wanda ya haifar da kwakwalwan ruwa da kuma hanzari na motsa jiki na ciki - wanda shine ƙarshen tare da alamun cututtukan cututtuka.
Ko da yake an yi tsammani cewa rashin lafiya ya shafi malabsorption, binciken da aka yi kwanan nan ya nuna cewa matsalar zai iya zama wani abu mai yawa na bile acid.
Wannan na iya zama saboda rashin aiki a cikin maɓallin amsa wanda ya kamata ya hana aikin samar da bile acid.
Dalilin
Wadannan matsalolin kiwon lafiyar zasu iya taimakawa wajen bunkasa BAD:
- Gida (ƙananan ciwo)
- Yin tiyata (sau da yawa a matsayin magani ga cutar Crohns)
- Gallbladder kau (cholecystectomy)
- Ƙananan kwayoyin cutar kanjamau (SIBO)
- Pancreatic insufficiency
- Radiation don ciwon daji
- Ƙunƙasar ƙwayoyin cuta
- Ƙananan ciwon ciwo
Cutar cututtuka
BAD ya nuna farko kamar yadda kwarewar cutar zazzage ta kasance. Wasu ko duk wadannan masu bayyanar cututtuka na iya kasancewa:
- Watery zawo
- Diarrhea tare da gaggawa
- Diarrhea a tsakiyar dare
- Matsala ta rufi
- Ruwan jini
Sanin asali
Doctors faye hali irin na bile acid malasorption ta hanyar, dangane da dalilin:
- Rubutun 1: Makarantar sakandare zuwa cutar ƙwallon ƙafa
- Nau'in 2: Idiopathic ko na farko (dalilin ba a sani ba)
- Rubutun 3: Makarantar sakandare zuwa duk sauran nau'o'in cututtukan gastrointestinal
Bisa sabon kallo akan rawar da aka sanyawa na maida martani ga jerin maganin bile acid, kalmar malassorption na asibiti na asibiti (I-BAM) tana iya fita daga ni'ima.
Gwaji
An gwada gwajin gwajin mafi kyau a gaban BAD da ake kira 75Se-homocholic acid taurine (75SeHCAT). Wannan jarrabawar magani ne na nukiliya wanda aka bai wa mai haɗin gwiwa wata hade don haɗiye da baki sannan kuma ya ɗauki cikakken tsarin jiki.
An sake gwada wani maimaita tsari sau bakwai bayan haka.
Hakanan ya ƙunshi SeHCAT, wanda aka yi amfani dashi don tantance yiwuwar ƙananan hanji don riƙe da bile acid. Kusan kashi 15 cikin 100 na ɗaukewa yana nuna alamar BAM.
Abin takaici, gwajin ba a samuwa a Amurka. An yi imanin cewa rashin samun damar shiga gwajin 75SeHCAT na taimakawa wajen ganewar asalin BAD.
Wasu likitoci sun juya zuwa gwaji don magani ga BAD a matsayin madadin gwajin 75 SeHCAT. Idan magani ya haifar da cigaba a cikin bayyanar cututtuka, BAD (ko BAM) ya zama ganewar asali.
Ɗaya daga ciki shine wannan daya daga cikin magunguna na farko da aka yi amfani da ita don BAD ba a yarda da shi ba. An sau da yawa an dakatar da shi - lokacin da mutane basu karbi ganewar asali wanda zai iya taimakawa tare da yarda da magani.
Har ila yau akwai hanya ta uku, an yi la'akari da mahimmanci, wanda ba'a amfani dashi kamar yadda yake buƙatar tanadi 24 da tara da kuma kasancewa na karamin rukuni na dakunan binciken bincike masu dacewa.
IBS-D ko Damarhea
Masu bincike na BAD sun yi imanin cewa mutane da yawa da ke da IBS-D ko zazzabin aiki a ainihin suna da BAD. Nazarin ya nuna cewa BAD zai iya zama kusan kashi daya cikin uku na lokuta na IBS-D da kuma kashi 40 zuwa 50 cikin lokuta na cututtuka na aikin.
Jiyya
A lokuta inda BAD ke haifar da cutar wanda aka gano, magani zai mayar da hankali ga magance wannan cuta kanta. A lokuta da babu dalilin da za'a iya gano, za'ayi amfani da BAD tare da wani magani wanda aka sani da masu biyan acid ko masu bindiga.
Irin waɗannan magungunan sun fara aiki a kan alamun BAD ta hanyar jingina ga acid kuma ta rage halayen su akan babban hanji. Wadannan sune mambobi ne na wannan kundin, wanda aka rubuta takardar izini don BAD za a dauke su akan-lakabi:
- Colestyramine (Questran)
- Colesevelam (WelChol)
- Colestipol (Colestid)
Wadannan magunguna suna da tasiri sosai wajen kawar da alamun BAD. Duk da haka, idan aka ba da magunguna a sashi don yanayin da suke da FDA, misali high cholesterol, sanyaya da sauran kwayoyin cututtuka na iya zama dandana. Idan an umarce ku daya daga cikin wadannan magunguna, yana da muhimmanci a yi aiki tare da likitan ku don samun sashi wanda ya dace muku.
Yana da muhimmanci a lura cewa waɗannan magunguna zasu iya shafar sauran magunguna da za ku iya ɗauka. Saboda haka, ya kamata a dauki su hudu zuwa shida na farko kafin ko bayan wani magani.
Kalma Daga
Ko da yake ana buƙatar ci gaba da binciken, zai zama a yanzu ya nuna cewa BAD yafi kowa fiye da yadda aka yi tunaninsa. Idan an gano ku tare da IBS-D ko kuma wani abu da ya dace da maganin cututtuka na ciwo na zafin jiki-kuma likitanku bai rigaya ya fita daga BAD ba-kuna so ku tattauna batun tare da su don ganin ko lafiyar wannan yanayin kiwon lafiya ba a cikin tushe ba na bayyanar cututtuka.
> Sources:
> DiBaise JK, Musulunci RS. Bile Acids: An Amince Da Ƙaƙƙwarar Da Ba a Yi Aiki ba . Gastroenterology na Gaskiya 2012 36 (10): 32-44.
> Pattni S, Walters J. Recent Ci gaba a fahimtar Bile Acid Malabsorption. Labarin Jaridar Birtaniya. 2009 92: 79-93.
> Walters JRF, Pattni SS. Gudanar da Gizon Bile Acid Diarrhea. Ci gaba da lafiya a Gastroenterology. 2010; 3 (6): 349-357.
> Abun ciki L, et.al. Binciken Tsare-tsaren: Tsarin Farko na Idiopathic Bile Acid Malabsorption kamar yadda bincikar SeHCAT ke dubawa a marasa lafiya tare da Diarrhea-Musamman Irritable Bowel Syndrome. Pharmacology Abinci da Therapeutics. 2009. 30: 707-717.