Ƙarin Mahimmancin Ƙarin Abinci ga Thyroid Treatment
Ɗaya daga cikin sababbin sababbin binciken a cikin nazarin maganin thyroid cutar shine fahimtar dangantakar dake tsakanin magungunan ƙwayar cuta 2 na masu ciwon sukari (sunan suna Glucophage) da kuma thyroid.
Ana amfani da Metformin don magance ciwon sukari na 2 da insulin juriya. Akwai haɗin da aka fahimta sosai tsakanin haɓakar insulin - mafi girma-fiye da al'ada na insulin, tare da matakan glucose na jini mafi girma wanda ya nuna insulin ba zai iya tasiri a rage rage jini ba - kuma ba kawai glandon thyroid (goiter) ba, amma a mafi girma tsinkaya na duka thyroid nodules da thyroid ciwon daji.
Abin sha'awa, sababbin binciken da aka buga a Journal of Endocrinology ya gano cewa marasa lafiya da aka bi da metformin suna da ƙananan ƙwayar jikinka da ƙananan TSH, amma kuma rage hadarin goiter, thyroid nodules, da ciwon maganin thyroid.
Game da Metformin
Metformin, wadda aka sayar a ƙarƙashin sunan Glucophage, an dauke shi da miyagun ƙwayoyi na farko da ake amfani dasu ga ciwon sukari na 2 , musamman ma marasa lafiya wadanda suke da karba . Metformin mai girma ne, yana nufin cewa yana rage yawan hawan ku na glucose, kuma yana ƙarfafa tunaninku ga insulin. {Asar Amirka ta fara amfani da metformin a 1995, kuma metformin ta zama magungunan maganganun maganganun da ake amfani da su, irin su 2, a dukan duniya. A {asar Amirka, yawan ku] a] e na tsarin metformin na daga $ 5 zuwa $ 25 kowace wata.
Metformin da Thyroid
Babban binciken da aka ruwaito a cikin Journal of Endocrinology ya dubi dangantakar da ke tsakanin metformin da aikin thyroid kuma ya taƙaita wasu mahimman tasiri na metformin wanda ke da alamun maganin karoid a nan gaba.
Musamman, nazarin ya ruwaito akan wasu mahimman bayanai:
- Metformin da Thyroid Cancer: Mai yawa binciken bincike ya nuna cewa metformin jinkirin girma daga thyroid cancers, kuma yana da abin da aka sani da aikin anti-proliferation. Metformin ƙananan rage ikon insulin don ƙarfafa ci gaban kwayoyin thyroid, da kwayoyin cututtukan ciwon thyroid, ciki har da kwayoyin cutar ciwon maganin thyroid . Metformin kuma inhibits girma da kuma hana metastases a medullary thyroid ciwon daji . Metformin yana nuna tsangwama tare da hanyoyi masu mahimmanci waɗanda ke inganta irin wannan girma.
- Metformin da thyroid Nodules: Metformin kuma yana da aikin haɓakawa tare da thyroid nodules, rage jinkirin girma ko rage girman su. Binciken ya nuna cewa binciken da ya gano cewa a marasa lafiya tare da karamin ƙwayar thyroid nodules da insulin gwagwarmaya, jiyya tare da metformin ya haifar da raguwa a cikin girman nodules, da kuma digo a cikin matakan TSH. Wani binciken da aka yi a kwanan nan game da mata da gwagwarmayar insulin da thyroid nodules sun gano cewa akwai yiwuwar karuwa mai yawa a cikin marasa lafiya da aka bi da metformin da levothyroxine, wanda aka yi amfani da shi kawai.
- Metformin da TSH Tacewa don Thyroid Ciwon daji Marasa lafiya: Metformin magani an hade da haɓaka da ƙananan matakai na TSH, yana nuna cewa yana iya taka rawar a halin yanzu maganin cututtuka na ciwon daji na thyroid wadanda aka yi niyya wajen kawar da matakan TSH don hana ciwon daji na ciwon ciwon daji. Metformin na iya zama da amfani sosai, saboda yana bayyana ya kawar da matakin TSH, ba tare da haifar da hyperthyroidism ba.
- Metformin da thyroid Yanayi a Type 2 Masu ciwon sukari: Akwai ƙididdigar tsararren likita na hypothyroidism a cikin irin 2 masu ciwon sukari a kan metformin far. Metformin yana hade da ƙananan matakan thyroid stimulating hormone (TSH) a cikin marasa lafiya na ciwon sukari. A cikin irin 2 marasa lafiya na ciwon sukari tare da ciwon maganin thyroid, magani tare da metformin an hade da haɓaka mai girma da kuma rayuwa a marasa lafiya na ciwon sukari tare da ciwon daji na thyroid, da kuma sakamako mafi kyau a cikin marasa lafiya na ciwon sukari tare da bambancin ciwon maganin thyroid wanda ya hadu da kwayoyin lymph. Masu bincike sunyi bayanin cewa metformin ya inganta illolin hormones a kan glandan.
Ƙididdigar Mahimmanci
Nazarin da aka nuna sun nuna cewa maye gurbin levothyroxine ba ta canza ta hanyar daukar metformin ba, saboda haka yana da lafiya ya dauki magunguna biyu a lokaci guda.
Amma kalubale shine, saboda metformin zai iya rage TSH ba tare da tasirin T4 ko T3 ba, bazai iya nuna gaskiyar halin da ake ciki na masu ciwon sukari iri biyu da hypothyroidism wadanda suke daukar metformin da levothyroxine ba. Hakanan zai iya maye gurbin maye gurbin masu ciwon sukari 2 masu ciwon daji na ciwon thyroid kuma wadanda ke buƙatar ba kawai rage matakan TSH ba, amma mafi girman matakan da ake ciki na T4 da T3 maganin karoid don hana ciwon daji.
A cewar masu bincike:
Matsayin TSH da aka tada yana tabbatar da tabbacin karya ko kuma zai iya kawo karshen farfadowa, ko masu binciken endocrinologists na iya rage [levothyroxine] sashi tare da matakin ƙimar TSH low. Dole ne likitoci suyi la'akari da tasirin metformin lokacin da suka fassara aikin kawanci don kauce wa duk wani magani da ya dace ko daidaitawa na [levothyroxine].
Rage sashi zai iya haifar da hypothyroidism bayyanar cututtuka don komawa saboda, duk da low TSH, akwai yiwuwar ba su isa circulating thyroid hormone don taimaka hypothyroid bayyanar cututtuka.
Bugu da ƙari, bayan tiyata don cire glandon don magance ciwon maganin thyroid, mutane da yawa marasa lafiya suna sakawa a kan maganin ciwo, kiyaye ƙwayar TSH da ƙananan ƙarancin karamar karoid don hana maganin ciwon daji na thyroid. Ga masu ciwon sukari 2 wadanda ke da ciwon maganin thyroid, kuma suna da thyroidectomy don cire glanden, wani TSH mai wucin gadi ta hanyar tsarin metformin na iya bayar da shawarar yin amfani da kashi kadan na levothyroxine. Wannan raguwa a cikin kashi, duk da haka, bazai iya samun nasara ba a matakin salula.
Kalma daga
Wadannan sababbin binciken da suke sha'awa suna nuna cewa akwai yiwuwar amfani da metformin a kungiyoyi masu yawa:
- Rubuta 2 masu ciwon sukari tare da cutar thyroid
- Rubuta 2 masu ciwon sukari wanda basu da cutar thyroid
- Mutane da ke da hypothyroidism wadanda ke da juriya na insulin, ciwo na rayuwa, da / ko kiba
- Ciwon daji na thyroid na TSH-suppressive far
A wannan yanayin, duk da haka, masana sun ba da shawarar ƙarin nazari na asibiti don inganta yadda ake amfani da metformin a matsayin ɓangare na maganin cutar karoid da kuma kafa ka'idojin magancewa da jagororin da za a iya magance su.
Idan kun kasance hypothyroid, kuma kuna da juriya na insulin, amma ba a ci gaba da shan metformin ba, yana iya zama da kyau don tattaunawa da likitanku game da ƙara da shi zuwa shirin kula da ku. Metformin an dauke shi magani ne mai lafiya tare da ƙananan cututtuka, kuma an wajabta shi don ciwo mai ciwo / pre-diabetes / insulin, kuma zai iya dakatar da cigaban ciwon sukari. Wadannan sababbin binciken sun nuna cewa yana iya samun sakamako mai kariya akan thyroid.
> Sources:
> Distiller LA, et al. "Rubutun ciwon sukari na 2 da hypothyroidism: yiwuwar tasirin metformin." Diabet Med 31 172-175. 2012.
> Xianghui M et al. "Duba: Metformin da kuma maganin thyroid." Jaridar Endocrinology. Amfani da yanar gizon, 14 Fabrairu 2017. Abstract / Full PDF