Psotic arthritis ne mai ciwon kwaɗayi irin na arthritis . Zai iya ci gaba kuma zai haifar da lalacewar haɗin gwiwa tare da rashin lafiya. Kullum, psoriatic arthritis an dauke rare, amma yana da mafi yawan mutane tare da psoriasis, shafi tsakanin 6-10% na psoriasis marasa lafiya. Yana da ma fi rinjaye a tsakanin wadanda ke da psoriasis mai tsanani, wanda ya shafi 20-40% na wannan rukuni na marasa lafiya.
Yana da muhimmanci a fahimci abubuwan haɗarin da ke hade da psotric arthritis. Matsayi mai hadari shine halayyar ko factor wanda zai kara yawan mutum zai iya inganta wani cuta ko yanayin. Bayanan haɗari an ƙayyade azaman mai sauyawa ko maras canji. Matsayi mai mahimmanci mai haɗari zai iya ba da zarafi don hana cututtukan zuciya na psoriatic ko kula da lalacewar da zata iya haifar.
Samun lamarin da ke tattare da cututtukan cututtuka na psoriatic ya ƙare. Akwai ƙananan binciken nazarin halittu da suka gwada abubuwan da ke damun cutar cutar psoriatic har sai shekara ta 2000. Har ila yau, akwai ƙananan binciken da suka bincika abubuwan haɗari don bunkasa cututtuka na psoriatic tsakanin mutanen dake da psoriasis. Masu bincike sun iya yin iyakacin cewa cututtuka na psoriatic yana iya tasowa saboda haɗuwa da kwayoyin halitta, immunologic, da kuma matsalolin halayyar muhalli.
Halitta
Kimanin kashi 40 cikin dari na marasa lafiya tare da psoriasis ko psthritic arthritis suna da 'yan uwa da suke da psoriasis ko psritic arthritis. Nazarin ya nuna cewa marasa lafiya da tarihin iyali na cututtukan cututtuka na psoriatic sun kasance sau 27-48 mafi kusantar su haifar da cutar fiye da wadanda ba tare da tarihin iyali ba.
An dauke cututtukan cututtuka na Psoriatic "mafi kyau sosai" fiye da sauran cututtuka na asibiti .
Yara na iyaye tare da psoriasis suna sau uku mafi kusantar su bunkasa psoriasis kuma suna da mafi girma hadarin bunkasa psoriatic arthritis idan aka kwatanta da yara iyaye ba tare da psoriasis. Idan maciji na biyu yana da ƙwayar cututtuka na psoriatic, ɗayan na biyu ma yana iya samun cutar ko don inganta shi a ƙarshe. Yawancin kwayoyin da suke hade da mai saukin kamuwa zuwa cututtukan cututtuka na psoriatic suna hade da mai saukin kamuwa zuwa psoriasis. Amma, ba duka kwayoyin suna hade da cututtukan biyu ba.
Immunologic
Dabbobi daban-daban na magance matsalar da ke taimakawa wajen bunkasa hadarin cututtuka na psoriatic. Tukan da aka kunna T sun kasance a cikin jiki na fata da ɗakunan. Ana kuma tsammanin cewa cytokine , irin su TNF-alpha, suna taka rawar a cikin tsarin kumburi wanda ke haifar da lalacewar furotin da ƙunƙashin fata wanda ke hade da psotric arthritis.
Muhalli
Akwai abubuwan muhalli wanda ya nuna alaka da hadarin bunkasa cututtuka na psoriatic. Bayyanawa ga wasu cututtuka an dauke shi a matsayin mai haɗari, musamman cutar cutptococcal. Ba'a tabbatar da haɗin da aka tabbatar ko tabbatar ba.
Har ila yau, maganin cututtuka na Psoriatic yafi kowa a cikin mutanen da suka kamu da kwayar cutar kanjamau (HIV) idan aka kwatanta da yawan jama'a.
Abin mamaki na Koebner, wanda ya faru a kashi 52 cikin dari na mutane da psoriasis bisa ga Kelley's Textbook of Rheumatology, an dauke wani matakan muhalli. Da farko dai Dr. Heinrich Koebner (wanda aka fi sani da dermatologist daga karni na 19) ya bayyana a cikin 1876, raunuka na psoriatic sun kasance a cikin jikin da ba a samu ba bayan fata. Abin da ke haifar da sabon abu na Koebner har yanzu ba a sani ba amma cytokines, sunadarai na danniya, kwayoyin adhesion, da autoantigens na iya zama hannu.
Sources:
Faɗakar da Hanyoyi Dama ga Psithic Arthritis: Harkokin Kimiyya Ya Haɗu da Bukatar Gwaji. Ogdie da Gelfand. JAMA Dermatology. Yuli 2010.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917977/
Bayanin haƙuri: Psotic arthritis (Beyond the Basics) Gladman da Ritchlin. Na zamani.
http://www.uptodate.com/contents/psoriatic-arthritis-beyond-the-basics
Psritic Arthritis. M. Elaine Husni. Cleveland Clinic. Agusta 2010.
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/rheumatology/psoriatic-arthritis/
Koebner mai cin nasara. Clinics a Dermatology. Sagi L. da Trau H. Maris-Afrilu 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21396563
Kelley's Textbook na Rheumatology. Tsarin na tara. Elsevier. Babi na 77. Psoriatic Arthritis. Oliver Fitzgerald.