Raminan , wanda aka yi la'akari da shi, yanzu yana da mashahuri. Ana samun ruwan 'ya'yan itacen ruwan inabi a kusan kowane kantin sayar da kayan kaya a Arewacin Amirka.
Amma rahoton da aka buga a ranar 1 ga Satumba, 2006, fitowar littafin Jaridar American Journal of Cardiology ya nuna cewa rumman na iya yin hulɗa da magungunan magunguna.
Wani mutum mai shekaru 48 yana ɗauke da azetimibe (Zetia®) 10 MG a rana da rosuvastatin (Crestor®) 5 MG kowace rana don watanni 17.
Ana amfani da dukkanin magunguna don high cholesterol.
Ya fara shan ruwan pomegranate (200 ml sau biyu a mako-mako) da makonni uku bayan haka, an shigar da shi da gaggawa tare da ciwon cinya da wani nau'in hawan gine-gine mai cin nama (138,030 U / L, al'ada <200 U / L). Dukansu sune bayyanar cututtuka na rhabdomyolysis, mummunar yanayin da ke haifar da lalacewar ƙwayoyin tsoka kuma zai iya haifar da gazawar koda.
Rosuvastatin yana cikin ƙungiyar magunguna da aka kira HMG-CoA reductase, ko 'statins'. Yawan 'ya'yan ganyayyaki ne da aka sani don kara yawan hadarin stin-induced myopathy, amma har zuwa yanzu, akwai kadan bayanai game da ko ruwan rumman zai iya ƙara haɗarin.
Ruwan 'ya'yan itace da ruwan' ya'yan tumatir, an san su ne don toshe tsarin tsarin sikila P450 3A4 a cikin hanji. Ta hanyar hana wadannan enzymes, juices na iya ƙara yawan jini na magunguna da dama.
Maganin Pamegranate-Drug Interactions
- Antiarrhythmics - Amiodarone (Cordarone®), disopyramide (Norpace®), quinidine
- Kwayoyin fasalin lamarin - Felodipine (Plendil®), Nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Statins - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®)
- Masu hana masu tsaro - Saquinavir (Fortovase®)
Duk da haka, ruwan 'ya'yan rumman na iya yin hulɗa tare da magunguna ba akan wannan jerin ba.
Ba a zaton cewa kwayoyin da ke da kwari da kuma rosuvastatin ba za a karya su ta hanyar cytochrome P450 3A4 ba.
Bisa la'akari da iyakacin shaida game da hulɗar miyagun ƙwayoyi, yana da muhimmanci ka yi magana da likitanka idan kana shan shan magani kuma suna yin la'akari da shan ruwan pomegranate.
Sources:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Hanyoyin ruwan pomegranate a kan ɗan adam cytochrome p450 3A (CYP3A) da kuma carbamazepine pharmacokinetics a cikin berayen. Damag Metabolism da Yanayi. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Hanyoyin hana ƙwayar 'ya'yan itace a kan aikin CYP3A. Damag Metabolism da Yanayi. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis hade tare da amfani da kwayar pomegranate. American Journal of Cardiology. 98.5 (2006): 705-6.
Bayani: Bayanan da aka ƙunshe a wannan shafin an yi nufi don dalilai na ilimi kawai kuma ba a maimakon shawara, ganewar asali ko magani ta likita mai lasisi. Ba'a nufin ɗaukar dukkan kariya, hulɗar miyagun ƙwayoyi, yanayi ko cutarwa. Ya kamata ku nemi kulawa da lafiya ga duk wani al'amura na kiwon lafiya ku tuntuɓi likitan ku kafin kuyi amfani da magani ko yin canji ga tsarinku.