Haɗuwa Drug Offers Cure Rates for Genotype 1 da 4 Cututtuka
Ƙayyadewa
Zepatier (elbasvir / grazoprevir) wani maganin hade ne mai maganin ƙwayar cuta wanda aka yi amfani dashi wajen kula da cutar rashin ciwon halayen C (HCV) . Magunguna guda biyu da suka hada da aikin Zepatier (elbasvir, grazoprevir) ta hanyar hana duk wani sinadaran (NS5a) da kuma enzyme (NS3 / 4a protease) mahimmanci don maganin cutar.
An amince da Zepatier a ranar 28 ga watan Janairun 2016 da Cibiyar Abinci da Drugura ta Amirka (FDA) don amfani da manya shekaru 18 ko fiye da tare da HCV genotype 1 ko 4 kamuwa da cuta , ciki har da wadanda ke da cirrhosis.
An yarda don amfani a duka marasa lafiya (marasa lafiya) ko waɗanda aka bari a baya (marasa lafiya), dangane da yanayin homogene HCV da halin magani.
Tabbatacce
Zepatier an ruwaito cewa yana da magani na musamman a cikin gwajin ɗan adam na II. An tabbatar da lafiyar HCV kamar yadda ake ci gaba da daukar nauyin hoto na kyamararru na tsawon makonni 24 bayan kammalawar farfadowa (wanda aka fi sani da cikewar maganganu na kwayar cutar , ko SVR ).
Hakanan SVR na gaba ya kasance daga 94% zuwa 97% a marasa lafiya da cutar HCV genotype 1, yayin da marasa lafiya da kwayar cutar genotype 4 sun ruwaito cewa suna da karfin SVR daga 97% zuwa 100%.
Yankewa
Ɗaya daga cikin kwamfutar hannu (50mg / 100mg) ana sha kullum tare da ko ba tare da abinci ba. Zepatier Allunan sune-mai siffar launin fata, mai launin shuɗi da kuma fim din-mai rufi, tare da "770" embossed a gefe ɗaya.
Bayyana shawarwarin
An tsara Zepatier ko dai tare da ko ba tare da ribavirin ba don kamuwa da cutar 1 ko 4. Ba kamar sauran hanyoyin maganin HCV ba, ba'a buƙatar maganin ƙwayar cuta (magungunan miyagun ƙwayoyi da ke haɗuwa da sauƙi).
Kafin farawar farfado, gwada gwajin kwayar halitta za a iya yi domin sanin ko kana da irin kwayar cutar wadda take da tsayayya ga ɓangaren Elbasvir na Zepatier (wanda aka sani da polymorphism hade NS5a).
Duration na farfadowa ya kasance daga makonni 12 zuwa 12, dangane da HCV genotype da halin magani.
| Genotype | Yanayin jiyya | Anyi tare da ribavirin? | Duration |
| Genotype 1a | jiyya-haushi ba tare da maganin elbasvir ba cutar | babu | Makonni 12 |
| jiyya-tsirar da elbasvir-resistant cutar | eh | 16 makonni | |
| an riga an bi da shi tare da ribavirin + peginterferon ba tare da cutar cutar ta elbasvir ba | babu | Makonni 12 | |
| an riga an bi da shi tare da ribavirin + maganin cutar da cutar ta Elbasvir-resistant | eh | 16 makonni | |
| an riga an bi da shi tare da ribavirin + pe pe pe pe ron ron ron + wani mai hana HCV protease | eh | Makonni 12 | |
| Genotype 1b | magani-tsirar | babu | Makonni 12 |
| an riga an bi da shi tare da ribavirin + yanki | babu | Makonni 12 | |
| an riga an bi da shi tare da ribavirin + haɓaka + mai haɓaka HCV protease * | eh | Makonni 12 | |
| Genotype 4 | magani-tsirar | babu | Makonni 12 |
| an riga an bi da shi tare da ribavirin + yanki | eh | 16 makonni |
* - Olysio (simeprevir), Victrelis (boceprevir), Haɗa (telaprevir)
Hanyoyin Kasuwanci
Abubuwa masu rinjaye na yau da kullum da ke hade da Zepatier amfani (faruwa a fiye da 5% marasa lafiya) su ne:
- Wulo
- Ciwon kai
- Jiɗa
Idan aka yi amfani da ribavirin, yawancin cututtukan da aka bayar da rahoto (wanda ke faruwa a cikin mutane fiye da 5%) sun hada da:
- Ciwon kai
- Wulo
- Anana
- Jiɗa
- Itchiness
- Nama
- Rawancin numfashi
- Insomnia
- Abin ciwo
- Rage ci
- Ƙara
- Madaba
- Rash
Drug Interactions
Wadannan magunguna ba za a yi amfani da su ba yayin shan Zepatier saboda suna iya haifar da hulɗar magungunan miyagun ƙwayoyi masu mahimmanci:
- Magunguna masu guba: nafcillin
- Abomin anticonvulsives: Dilantin (phenytoin), Tegretol (carbamazepine)
- Antifungals: Allunan Bidiyo Nizoral (ketoconazole)
- Magungunan anti-hypertensive: Tracleer (bosentan)
- Namun kayan lambu: St. John's Wort
- Kwayoyin maganin kwayar cutar kwayar cutar HIV: Aptivus (tipranavir), Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide), Halin (etravirine), Invirase (saquinavir), Kaletra (lopinavir, ritonavir), Prezista (darunavir), Reyataz (atazanvir), Stribild ( elvitegravir, cobicistat, emtricitabine, tenofovir disproxil), Sustiva (efavirenz),
- Immunosuppressant kwayoyi amfani da su hana organ transplant kin amincewa: cyclosporine
- Magungunan Rifampin da aka yi amfani da su a maganin tarin fuka: Mycobutin, Priftin, Rifater, Rifamate, Rimactane, Rifadin
Ra'ayin Nazarin
An bayar da rahoto a binciken binciken asibiti cewa kashi 1 cikin dari na marasa lafiya a Zepatier sun ci gaba da tayar da haɗari a cikin hanta enzymes wanda ke nuna rashin ciwon hanta, kullum a ko bayan makon takwas na farfadowa. Saboda haka, ana buƙatar yin gwaje-gwaje na jini dangane da hanta kafin a fara farfadowa da kuma a kai a kai a lokacin lokacin HCV.
Kada a ba Zepatier umarni ga marasa lafiya da rashin ciwon hanta mai tsanani.
Ana amfani da amfani da ribavirin a cikin ciki kuma bai kamata a ba shi izini ba tare da Zepatier ko wani magungunan ƙwayar cutar Cizzanci. Dole ne a umarci marasa lafiya a cikin maganin ribavirin da ya kamata su kauce wa ciki da kuma amfani da akalla hanyoyi guda biyu na hana haihuwa a lokacin farfadowa da kuma watanni shida bayan kammala aikin farfadowa.
Source:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta amince da Zepatier don magance cutar da cutar hepatitis C ta 1 da 4." Silver Spring, Maryland; sanarwa da aka bayar ranar 28 ga watan Janairu, 2016.
Merck. "Zepatier - Karin Bayani na Bayani Bayanan." Kenilworth, New Jersey; isa ga Janairu 29, 2016.