Inganta haɗin Drug Offers Ƙananan Hanyoyin Hanya
Ƙayyadewa
Odefsey daya takarda ne, maganin hade da ake amfani da shi a maganin HIV, wanda ya kunshi nau'o'i daban-daban guda uku:
- rilpivirine , wanda ba shi da magungunan baya wanda ya hana shi (NNRTI)
- emtricitabine, mai ƙwayar magungunan ƙaddamar da ƙwayar cuta ta tsakiya (NtRTI)
- tenofovir alafenamide (TAF) , wani NtRTI
Odefsey shi ne karo na biyu hade da ƙwayoyi don amfani da TAF, wani fashewar "inganta" na tenofovir disoproxil fumarate (TDF) da aka gano a cikin kwayoyi Truvada da Atripla .
Saboda haka, ana iya la'akari da ci gaba a kan Ƙarshe, tsarin da aka haɗa da rilpivirine + emtricitabine + TDF.
TAF yana da daraja ga TDF saboda yana iya ba da magani mafi dacewa a cikin kwayoyin halitta kuma a cikin ƙananan ƙwayoyin-ma'anar cewa akwai ƙananan ƙwayar miyagun ƙwayoyi a cikin jini da kuma rashin damar yin amfani da ƙwayar cutar koda.
(Yayin da ake la'akari da haɗarin cutar TDF a matsayin kasa a kasashe masu tasowa, ana ganin wannan hadarin ya tashi da yawa a kasashe masu tasowa inda akwai yiwuwar haddasa ciwon koda a yanzu.
Jiyya Kula
Cibiyar Abinci da Drug ta Amurka ta amince da Odefsey a ranar 1 ga Maris, 2016, don amfani da duka yara da yara fiye da shekaru 12 da basu taba yin cutar kanjamau ba , wadanda ke da nauyin kwayar cutar kwayar kwayar cutar 100,000 ko m, 77 fam (35kg) ko fiye.
Odefsey kuma za'a iya amfani da shi don maye gurbin farfadowa na yanzu (kamar su a cikakke) idan mai haƙuri ya sami nauyin hoto mai ban tsoro (<50 kwayoyin / mL) don akalla watanni shida, ba shi da tarihin rashin nasarar maganin, kuma ba a san shi ba. juriya ga kowane ɓangaren magunguna a Odefsey.
Halitta
Odefsey mai launin toka ne, oblong, kwamfutar hannu mai launi, ya hada da 25mg na rilpivirine, 200mg na emtricitabine da 25 MG na TAF.
An sanya shi da "GSI" a gefe daya kuma tare da "255" a daya.
Yankewa
Ɗaya daga cikin kwamfutar hannu yau da kullum da aka ci tare da abinci. Odefsey ba za a dauka tare da wani magungunan maganin rigakafi wanda ke amfani da cutar HIV ba.
Hanyoyin Gaba
An gano wasu alamun maganin miyagun ƙwayoyi a cikin gwaji masu gwaji na shan rilpivirine da / ko emtricitabine + TAF, mafi yawan sune:
- Jiɗa
- Ciwon kai
- Insomnia
- Dama
Hanyoyin da ke faruwa a kullum sun wuce, tare da ƙananan marasa lafiya sun daina sakamakon rashin haƙuri.
Contraindications
Odefsey ba za a dauka tare da wadannan kwayoyi ko kari ba:
- Magunguna masu guba: Tegretol, Trilepta, phenobarbital, phenytoin
- Tarin maganin tarin fuka: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Proton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex ko wani PPI
- Magungunan steroid: dexamethasone (ko da yake za'a iya gudanar da shi a cikin kashi guda, idan aka nuna ta hanyar likita)
- St. John's Wort
Koyaushe sanar da likitanka game da duk wani magani ko kari, wanda aka tsara ko ba a ba shi ba, wanda za ka iya ɗauka kafin ka fara wani maganin antiretroviral.
Sauran Bayanai
Odefsey ba a ba da shawarar ga marasa lafiya da rashin nauyin koda (wanda aka kiyasta cewa yana da kimanin kashi 90mL a minti daya).
Don Allah a ba da shawara ga likitanku idan an kasance ko an kula da ku saboda kowace cuta ta koda ta wani likita.
Odefsey ba a ba da shawarar ga marasa lafiya da rashin hanta ba ko wadanda ke fama da ciwon hawan B (HBV) na kullum wanda zai iya haifar da matsalolin hanta. Ana ba da shawara cewa mutane da ke dauke da kwayar cutar HIV za su kula da HBV kafin su tsara Odefsey. Don Allah a shawarci likitan ku idan kuna da wata matsalar hanta da / ko tarihin hepatitis.
Rigpivirine na bangaren Odefsy na iya haifar da cututtuka a cikin ƙananan marasa lafiya, sau da yawa a cikin wani mummunan rauni, ƙurar ido ("launin ruwan hoda"), fatar jiki, zazzabi, ko sauran amsa masu rashin lafiyar.
Yawancin lokaci, halayen kamuwa da cututtuka ba zai wuce makonni shida ba bayan ya fara farfadowa. Sanar da likitanku nan da nan daga kowane irin alamun bayyanar ya bayyana. A cikin lokuta masu tsanani, za a iya dakatar da farfadowa.
Sources:
Reuters. "BRIEF - Kimiyya ta Gileyad ce FDA ta amince da Odefsey." An sake shi ranar Maris 1, 2015.
Kimiyya ta Gilead. " Odefsey - Karin Bayani na Bayani Bayanan." Foster City, California; isa ga Maris 18, 2016.