HIV kwayoyi ba kawai Case na Jiki Fat Canje-canje
Labaran jini , wani lokacin da ba a iya sake gyara jiki ba, an yi la'akari dashi a matsayin wani sakamako mai tasiri da wasu magungunan antiretroviral , musamman ma tsohuwar tsarawa kamar Zerit (stavudine) da Retrovir (AZT), wanda ke cikin wata magungunan miyagun ƙwayoyi da ake kira juzu'i baya. masu ƙuntataccen sakonnin .
A cikin 'yan shekarun nan, an saka wasu jami'ai a jerin wadanda ake tuhuma, ciki har da Sustiva (efavirenz), Isentress (raltegravir), da kuma nau'in kwayoyin cutar HIV da ake kira masu zanga-zangar protease .
Da wannan aka ce, ainihin dalilin lipodystrophy- ko kuma a hanyar hanyar tarawa (lipohypertrophy) ko asarar mai (lipoatrophy) -ma ya zama mafi mahimmanci. Ƙarin shaida ya nuna cewa HIV kanta, da kuma ciwon haɗari da ke haɗuwa da kamuwa da cuta , na iya kasancewa masu bada gudummawa, ko da yake har kwanan nan an sami kananan bayanai don tabbatar da wannan.
Binciken da aka yi a 2015 wanda ya gabatar a taron kan Rubuce-rubuce da Hanyoyin Hanyoyin Ciki a Seattle ya taimaka wasu haske akan batun. Bisa ga binciken, mutanen da ke dauke da nauyin maganin kyamarar kyamarar kwayar cutar a farkon fararen (fiye da 100,000 kofe / ML) sun bayyana cewa suna da tsinkaye ga lipodystrophy fiye da wadanda ke dauke da nauyin nau'i na kyamarar hoto.
Binciken Nazarin da Sakamako
Bincike na 96 na mako, wanda masu bincike a Case Western Reserve Jami'ar Ohio suka gudanar, sun yi rajistar 328 marasa lafiya na HIV ba tare da nuna jin dadin su ba. Yawan shekarun shekaru 36 ne; 90% sun kasance namiji.
Kowane mahalarta an tsara shi daya daga cikin magungunan miyagun kwayoyi guda uku, wanda ya haɗa da kashin baya na Truvada (tenofovir + emtricitabine) da kuma dai
- Reyataz (atazanavir) + Norvir (ritonavir),
- Prezista (darunavir) + Norvir (ritonavir), ko
- Isentress (raltegravir).
A lokacin binciken, an ba marasa lafiya CAT da DEXA (dual energy energy absorptiometry) don gwada canje-canje a cikin jiki.
Duk da yake an yi tsammanin cewa kwayoyin cututtuka daban-daban za su shafi sakamako daban-daban a cikin marasa lafiya, masana kimiyya sun yi mamakin ganin cewa karamin jiki yana karuwa kamar yadda ya shafi dukkanin kungiyoyi. Yawanci, yawan jikin mutum ya karu da kashi 3% zuwa 3.5%, yayin da ƙwayar manya ta karu da kashi 11% zuwa 20% kuma yawancin jiki ya karu daga 16% zuwa 29%.
Bambanci kawai wanda zasu iya samuwa shine a cikin nauyin maganin hoto na marasa lafiya. A wa] anda ke da nauyin kayan haya mai magungunan hoto, ƙwayar visceral (watau a cikin rami na ciki) ya karu da kashi 35% ba tare da la'akari da magani ko magani ba. A bambanta, marasa lafiya da kwayoyi masu dauke da kwayar cutar a ƙarƙashin 100,000 kofe / mL sun samu kawai 14% tare da Isentress da kasa da 10% tare da masu hana masu protease.
Bugu da ƙari, haɗuwa a cikin Interleukin-6 (IL-6), alamar aikin kunnawa, an hade shi tare da ƙãra jiki mai laushi (watau, mai sauƙi a ƙarƙashin fata). Wannan yana nuna cewa ƙunƙwarar cutar ta HIV tana taka muhimmiyar rawa wajen samar da kitsen mai amfani, ko dai a cikin kwakwalwa ko kuma mai zaman kanta daga aikin magance cutar.
Ko da kuwa abubuwan da suke haifarwa ko dalilai masu gudummawa, cin hanci da yawa na visceral na 30% fiye da shekaru biyu yana da tsanani, ɗauke da shi na tsawon lokaci na cutar cututtukan zuciya , ciwon sukari , da dyslipidemia .
Abubuwan binciken zasu iya samar da ƙarin shaida game da amfanin magani a kan ganewar asali , kafin an ɗora kayan hawan hoto ko girman CD4 .
Sources:
McComsey, G .; Moser, C .; Ribaudo, H .; et al. "Hanyoyin Jiki na Canje-canje Bayan Gyara Raltegravir ko Masu Kare Masu Tsaro." Taron kan Magunguna da Hanyoyin Ciki (CROI); Seattle, Washington; Fabrairu 23-26, 2015; m 140.
Virolet, C .: Delhumeau-Cartier, C .; Sartori, M .; et al. "Lipodystrophy daga masu cutar HIV dauke da kwayar cutar: wani binciken giciye a kan tasiri a kan ingancin rayuwa da kuma tunanin kiwon lafiya mentally." AIDS Research and Far. 2015; 12-21: DOI 10.1186 / s12981-051-0061-z.