Ƙayyadewa
Viekira Pak wani haɗin gwiwar hada-hadar miyagun ƙwayoyi ne da ake amfani dashi don magance cutar mai ciwon hauka C (HCV) . Shirin ya hada da takaddun maganin maganin Technivie (ombitasvir + paritaprevir + ritonavir) tare da maganin miyagun ƙwayoyi.
A miyagun ƙwayoyi aka gyara ombitasvir, paritaprevir da dasabuvir su ne wadanda suke aiki da hanzari (DAAs) wadanda suke tsangwama tare da maganin cutar.
Magungunan magani na ritonavir , wanda ake amfani dashi akai-akai a cikin kwayar cutar HIV , an hada shi don bunkasa matakan miyagun ƙwayoyi na paritaprevir.
Viekira Pak ne mafi sau da yawa, amma ba koyaushe, an haɗa shi tare da ribavirin ba kuma baya buƙatar ɗauka tare da interferon na peggy (peg-interferon).
An amince da Dokar Viekira Pak a ranar 19 ga watan Disamban shekarar 2014, da Cibiyar Abinci da Drugura ta Amurka (FDA) don amfani da manya shekaru 18 ko fiye tare da kamuwa da cutar HCV genotypes 1, ciki har da wadanda ke da cirrhosis da aka biya (wanda hanta ke ci gaba da aiki) da hanta. Ga marasa lafiya tare da cirrhosis, ba a ba da shawarar Viekira Pak ba.
An bayar da rahoton cewa Viekira Pak yana da magani na 95% ko fiye, tare da kawai kashi 2 cikin dari na marasa lafiya marasa lafiya da ke rashin lafiya. Ya dace don amfani da marasa lafiya da cutar HIV / HCV .
Yankewa
Allunan Allunan guda biyu na kwaminis na ombitasvir + paritaprevir + ritonavir (25mg / 150mg / 100mg) dauka kowace rana kowace rana tare da abinci, tare da teburin dasabuvir sau biyu a kowace rana da safe da maraice tare da abinci.
Allunan suna dacewa a cikin kwaskwarima a kowace rana, tare da umarnin dosing da aka haɗa a kowane akwatin. Rubutun da aka tsara shi ne ruwan hoda, mai shafe-raye da kuma hotunan tare da "AV1", yayin da kwamfutar da aka yi amfani da shi ta zama mai tsayi, mai hotunan fina-finai da kuma horar da "AV2".
Bayyana shawarwarin
An tsara Viekira Pak a kan kati na 12 zuwa 24, kamar yadda wadannan shawarwari suka bayar:
- Genotype 1a ba tare da cirrhosis: Viekira Pak tare da ribavirin na makonni 12
- Genotype 1a tare da cirrhosis: Viekira Pak tare da ribavirin tsawon makonni 24
- Genotype 1b ba tare da cirrhosis ba: Viekira Pak kawai don makonni 12
- Genotype 1b ba tare da cirrhosis ba: Viekira Pak tare da ribavirin tsawon makonni 24
Ga masu hade da hanta na hanta, ana iya ɗaukar Viekira Pak tare da ribavirin har tsawon makonni 24 kawai idan aikin hanta (hanta) na al'ada ne kuma fibrosis (scarring) shine ƙananan.
Hanyoyin Kasuwanci
Hanyoyin da suka shafi halayen da suka hada da amfani da Viekira Pak (faruwa a har zuwa 10% na marasa lafiya) sune:
- Wulo
- Jiɗa
- Itchy fata
- Skin cututtuka
- Insomnia
- Dama da gajiya
Drug Interactions
Dole ne a kauce wa wadannan a yayin amfani da Viekira Pak:
- Masu amfani da kwayoyi: carbamazepine, phenytoin, phenobarbital
- Antihyperlipidemics (amfani da su rage matakan lipid a cikin jini): gemfibrozil
- Anti-arrhythmia magani: pimozide
- Cholesterol-ragewan magani: lovastatin, simvastatin
- Amfani da maganin dasfunni na Erectile: Viagra (sildenafil)
- Ergot-dauke da magani (amfani dasu don ciwon ciwon kai da migraines): ergotamine, dihydroergotamine, ergonovine, methylergonovine
- Ethinyl estradiol (siffar estrogen)
- Magungunan kwayar cutar HIV : Sustiva (efavirenz) , Atripla (danna + tenofovir + emtricitabine)
- Maganin hypotension: alfuzosin
- Magunguna masu maganin tarin fuka-fuka na Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: triazolam, midazolam m
Contraindications da tunani
Ga marasa lafiya da rashin rashin lafiya na rashin lafiya, Viekira Pak ba da shawarar. An haramta Viekira Pak don amfani da marasa lafiya tare da rashin lafiya.
Haka kuma Viekira Pak yana hana yin amfani da shi a cikin haƙuri tare da sanannun sanarwa ga ritonavir (ciki har da Stevens-Johnson Syndrome, wani mummunar barazanar rayuwa, duk wani mummunan aikin jiki).
An haramta Viekira Pak don amfani a cikin mata masu ciki yayin amfani da ribavirin.
An ba da shawarar cewa a lura da dukan mata masu haihuwa a kowane wata don yin ciki a lokacin farfadowa. An kuma bada shawara cewa a yi wa mai haƙuri da abokinta a cikin wasu hanyoyi guda biyu na maganin hana haihuwa, da kuma amfani da su a lokacin farfadowa da kuma watanni shida bayan haka.
Source:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta amince da Viekira Pak don magance cutar hepatitis C." Silver Spring, Maryland; sanarwa da aka buga ranar Disamba 19, 2014.