Sovaldi (Sofosbuvir) wani littafi ne mai amfani da kwayoyin maganin ciwon maganin ƙwayoyin cutar polymerase wanda aka yi amfani da shi a hadewar maganin cutar maganin ciwon haifa C (HCV) . Sovaldi yana aiki ne ta hanyar hana wani enzyme wanda HCV yayi amfani da shi don yin amfani da RNA, ta yadda zai katse wani mataki a cikin kwayar cutar.
Sovaldi ya amince da shi a watan Disambar 2013 ta Cibiyar Abinci da Drugura ta Amirka (FDA) don amfani da manya shekaru 18 ko fiye da kamuwa da cutar HCV 1, 2, 3 da 4, ciki har da wadanda ke da ciwon sukarin mai ciwon hepatocellular (yawancin cutar ciwon hanta) da kuma mutanen da ke dauke da cutar HIV / HCV .
An yarda da Sovaldi don amfani a cikin marasa lafiya (marasa lafiya-marasa lafiya) marasa lafiya, da wadanda ke da karɓa ko a'a a mayar da martani ga HCV.
Bincike na asibiti ya nuna cewa maganin magani ga marasa lafiya-marasa lafiya a tsarin tsarin Sovaldi yana tsakanin 82% da 96%.
Yankewa
Ɗaya daga cikin kwamfutar hannu guda 400 na yau da kullum tare da ko ba tare da abinci ba. Allunan na Sovaldi sune rawaya da kuma hotunan fina-finai, tare da "GSI" wanda aka saka a gefe daya kuma "7977" a daya.
Bayyana shawarwarin
An tsara Sovaldi don yin amfani da shi tare da ribavirin ; tare da duka biyu tare da alamar interferon (peg-interferon) + ribavirin; ko tare da Daklinza (daclatasvir) . Sovaldi dole ne ba za a yi amfani da shi kamar yadda monotherapy.
Ana bada shawarar tsarin tsarin kulawa da haka:
- Genotype 1 ko 4: Sovaldi + peg-interferon + ribavirin na makonni 12
- Genotype 2: Sovaldi + ribavirin na makonni 12.
- Genotype 3: Sovaldi + ribavirin har tsawon makonni 24 KO Sovaldi + Daklinza (daclatasvir) na makonni 12
Ga marasa lafiya da kwayar jini 1 wadanda basu cancanta ba don interferon ko interferon-inlerant, an bayar da shawarar cewa a hade da Sovaldi + ribavirin a wajabta na 24 makonni.
Ga duk mai haƙuri da ke jiran hawan hanta, dole ne a ba da izinin maganin ƙwaƙwalwar da aka ambata a sama ko dai a cikin makonni 48 ko kuma har sai an yi dashi, duk wanda ya fara.
Hanyoyin Kasuwanci
Hanyoyin da suka shafi halayen da suka haɗa da amfani da Sovaldi + ribavirin (watau, faruwa a 20% ko žasa marasa lafiya) sune:
- Wulo
- Ciwon kai
- Jiɗa
Sakamakon sakamako mafi yawan da aka gani a cikin marasa lafiya ta yin amfani da Sovaldi + ribavirin + peg-interferon su ne:
- Wulo
- Ciwon kai
- Jiɗa
- Insomnia
- Anana
Baya ga anemia da neutropenia, yawancin abubuwan da ke tattare da Sovaldi amfani da su suna dauke da m ko m (Grade 1).
A binciken bincike na asibiti, 1% ko ƙasa da marasa lafiya a Sovaldi + ribavirin sun farfasa farfadowa saboda rashin tasiri. Abinda ya faru ya karu zuwa 11% ga marasa lafiya a Sovaldi + ribavirin + peg-interferon.
Drug Interactions
Dole ne a kauce wa wadannan a yayin amfani da Sovaldi:
- Magunguna masu maganin tarin fuka-fuka na Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- St. John's Wort
Ga marasa lafiya da kwayar cutar HIV , Sovaldi ba za a yi amfani da su ba tare da Abtivus (tipranavir) ko Norvir (ritonavir) a matsayin waɗannan masu kare maganin protease wadanda zasu iya rage zubar da jini na Sovaldi.
Contraindications
An yi amfani da Sovaldi don yin amfani a lokacin daukar ciki ko kuma a cikin maza waɗanda suke da juna biyu a ciki kamar yadda binciken dabbobi ya nuna yiwuwar hadarin rashin lalata haihuwa ko mutuwar tayi.
An ba da shawarar cewa a lura da dukan mata masu haihuwa a kowane wata don yin ciki a lokacin farfadowa. An kuma bada shawara cewa a yi wa mai haƙuri da abokinta a cikin wasu hanyoyi guda biyu na hana haihuwa da kuma ana amfani dasu a lokacin farfadowa da kuma watanni shida bayan haka.
Source:
Manns, M. da Cornberg, M. "Sofosbuvir: ƙusa ta karshe a cikin akwati don cutar hepatitis C?" Lancet. Maris 15, 2013; 13 (5): 378-379.