Bincike ya Bayyana cututtuka
Bincike a cikin wadanda basu san hankali ba - wanda aka fi sani da rashin karuwanci - ƙara ƙarawa yana tabbatar da cewa za ku iya samun mummunan cututtuka daga cin abinci mai guba ba tare da cututtukan celiac ba .
A cikin binciken da aka gano a kan binciken da aka gano a farkon shekara ta 2011, masanin kimiyyar celiac, Dr. Alessio Fasano, ya tabbatar da cewa "gwaninta" yana nuna bambanci ne daga cututtukan Celiac, kuma mafi yawan mutanen da ke fama da rashin lafiyar gurasar ba za su ci gaba da yin celiac ba.
Duk da yake bincikensa yana da sha'awa ga al'ummar likita, yana da mahimmanci a lura cewa bincikensa ba tukuna ba tukuna kuma don haka likitocin kiwon lafiya har yanzu suna daukar wannan ka'idar a ci gaba.
Dokta Fasano da ƙungiya sun kasance masu bincike mai tsanani na Celiac, ciki har da Drs. Peter Green (shugaban Cibiyar Celiac Cibiyar Columbia) da Dokta Marios Hadjivassiliou (masanin ilimin kimiyya da masanin kimiyya), ya biyo bayan binciken da aka fara a watan Fabrairun 2012 inda ya gabatar da hanyoyin da za a bambanta tsakanin cutar celiac, gluten da hankali, da kuma abin da ake amfani da shi.
Har ila yau, masu bincike sun sake yin amfani da binciken. Wasu nazarin na nuna cewa wasu mutane masu yawan alwala suna da irin wadannan bayanan martaba zuwa ga celiac da aka bincikar su, suna nuna cewa akwai yanayin pre-celiac. Sauran nazarin binciken da Dr. Fasano ya gano cewa gurasar zai iya haifar da bayyanar cututtuka a cikin mutanen da basu da cututtukan Celiac.
Bincike a cikin basirar hankali yana ci gaba da sauri. Bugu da ƙari, yawancin lokaci da yawa, mutanen da ke da kwayar cutar jini ta hanyar celiac amma an ba da halayen kwayar cutar ta hanzari.
A wasu lokuta, likitan su ya ce za su iya cin abinci a cikin daidaituwa, ko kuma ana gaya musu cewa su bi abincin cin abinci maras amfani amma ba su bukatar su zama masu hankali kamar marasa lafiya na celiac.
Ana gaya wa wasu cewa "marasa lafiya" marasa lafiyar Celiac ne, kuma su sake dubawa a cikin shekara ɗaya don haka don ƙarin gwaji don ganin idan sun bunkasa yanayin.
Za a buƙaci ƙarin bincike don sanin idan mutane da ƙwarewa za su iya amfani da ƙananan gurasar ba tare da lalacewa ba, ko kuma idan wani ɓangaren ƙananan ƙwayoyi masu guba za su ci gaba da bunkasa cutar celiac.
Kara karantawa akan yiwuwar hadarin kiwon lafiya a hankali mai kyau: Gluten Sensitivity Health Risks
U. na Maryland Pegs 'Gluten Sensitivity' a matsayin Gaskiya
A cikin binciken Dokta Fasano na farko, wanda aka buga a cikin watan Maris na 2011 a BMC Medicine , masu bincike sun gano bambancin bambanci tsakanin cutar celiac da kuma ƙwarewa a kan matakin kwayoyin, kodayake alamun yanayin yanayin biyu sun ɓace sosai.
Dokta Fasano da sauran jami'o'in Jami'ar Maryland sun kwatanta adadin wadanda suka kamu da cutar ta Marsh 3 ko Marsh 4 tare da mutane 26 wadanda hankalinsu ya nuna kadan ko babu lalacewa, amma wanda har yanzu an mayar da ita ga alkama.
Ga kowane ɗan takara, masu bincike sun ƙaddara yawan ƙwayar hanzari na ciki (a cikin cutar celiac, hanzarinka ya zama ƙari, wanda zai iya ba da damar sunadarai su tsere a cikin jini).
Sun kuma kallo kwayoyin halitta, tare da bayyana kwayoyin halitta a cikin ƙananan hanji.
Binciken ya samo bambance-bambance a cikin kwakwalwa da ke tsakanin kungiyoyin mutane, tare da bambance-bambance a cikin maganganun jinsin da ke tsara maganin gaggawa. Wannan yana nuna alamar ƙwayar ruwa mai sauƙi ne kamar cututtukan Celiac , in ji Dr. Fasano.
Differences a cikin Celiac, Gluten Sensitivity Stem Daga Rigaka Answers System
Bambance-bambance tsakanin ka'idodi guda biyu ya haifar da martani ga tsarin magance rigakafi, Dokta Fasano ya ce.
A cikin ƙwarewar ƙwayar cuta, tsarin da ba shi da mawuyacin hali - wani ɓangaren ɓangare na tsarin rigakafi da na farko na kare lafiyar jiki ta hanyar masu mamayewa - yayi amsa ga cin hanci da yalwaci ta hanyar fadawa gurasar kai tsaye.
Wannan yana haifar da kumburi a ciki da waje da tsarin narkewa, in ji Dr. Fasano.
A halin yanzu, cututtukan Celiac ya shafi duka kwayoyin halitta marasa tsari da kuma tsarin rigakafi, ya ce. Tsarin na rigakafi mai sauki shine wani ɓangare na ci gaba, sophisticated na tsarin rigakafi, da kuma rikitarwa a tsakanin tsarin tsarin da bazatawa ya haifar da waɗannan kwayoyin don yaki da kayan jikinka na jiki, haifar da ciwon daji wanda aka gani a cutar celiac.
Mutanen da ke dauke da ciwon sukari ba su da kullun kwayoyin cutar, ko da yake suna iya samun alamun bayyanar cututtuka ga celiac, ciki har da zazzabin ciki, shan jini, ciwo na ciki, zafi ciwon zuciya , damuwa , ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta da kuma migraines, in ji Dr. Fasano. (Kara karantawa akan yiwuwar bayyanar cututtuka a nan: Gluten Sensitivity Symptoms .)
Duk da haka, kawai mutanen da ke da tsarin maganin rigakafi na musamman ga cututtukan celiac suna cikin haɗari don bunkasa lymphoma na hanji da sauran yanayin da ke hade da celiac, irin su osteoporosis , Dr. Fasano ya ce.
Wasu daga cikin mutanen da suka sha wahala a cikin binciken da Dokar Dr. Fasano ya yi sunyi mummunar lalacewa (wanda aka fi sani da Marsh 1 ko 2 ), amma wannan lalacewar ya bambanta da wadanda suke gani a cikin celiac.
'Masu Amfani' Celiac Patients Raba Dattijai na Metabolic Tsakanin Tare da Celiacs
Akwai wasu bincike da ke nuna wasu mutane da ake kira "mai karfin gaske" na iya, a gaskiya, da cutar cutar celiac da wuri.
Wani binciken da aka wallafa a cikin Disamba 2010 Journal of Research Protect ya gano cewa marasa lafiyar Celiac "mai yiwuwa" sunyi gwajin gwagwarmaya amma kwayoyin biopsies na hakika suna da irin wannan zanen yatsa kamar yadda ake gano celiac. Wadannan mutane "masu lalata" suna iya nuna matsayin farko na yanayin kafin ya haifar da mummunar lalacewa ga hanji, inji masu bincike.
Binciken ya yi amfani da alamar nazarin halittu mai kwakwalwa don nazarin alamun kwayoyin halitta a cikin fitsari da jini na marasa lafiya 141: 61 tare da cututtukan Celiac da aka gano, 29 tare da gwaje-gwaje na jini mai kyau amma biopsies masu cin hanci, da kuma kyawawan lafiya guda 51.
Sun gano cewa wadanda ke dauke da cutar "Celsique" wanda ake kira "mai yiwuwa" sun raba wannan asalin biochemical kamar yadda samfurin celiac ne aka gano, yayin da bayanan biochemical na kula da lafiya ya saba da alama.
"Sakamakonmu ya nuna cewa gyare-gyare na rayuwa na iya ƙaddamar da ci gaban ƙananan ciwon guraben ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta da kuma samar da wata mahimmanci ga tsarin kula da GFD [cin abinci marasa cin abinci] a marasa lafiya da CD [celiac cuta]," in ji binciken.
Gluten Sensitivity Mai yiwuwa a marasa lafiya tare da Borderline Biopsies
Wani binciken kuma ya dubi marasa lafiya da cututtukan Celiac da ke nuna cewa cututtuka na jikin mutum ne kawai suka bayyana kawai ƙananan ƙananan hauka, irin su Marsh I ko II .
Yawancin likitoci ba za su gane asalin cututtukan Celiac ba sai dai lalacewar asibiti sun kai matakan Marsh III ko Marsh IV .
A cikin wannan binciken, marasa lafiya 35 sun sami mummunar lalacewa kuma an shawarce su su bi abinci marar yalwa. Sai dai marasa lafiya 23 kawai sun ci abinci kuma masu binciken suka biyo bayan biopsies daga kowa da kowa bayan cin abinci bayan watanni takwas zuwa 12.
Dukkanin marasa lafiya 23 da suka bi abincin suna da "ingantacciyar haɓaka ta asibiti a cikin bayyanar cututtuka," kuma mafi yawan sun ga warkaswa ko kuma warkaswa na kwaskwarima.
Bakwai daga cikin marasa lafiya 11 da suka ƙi biyan abinci mai cin abinci ba tare da cin abinci ba ne aka kimanta watanni takwas zuwa 12 bayan haka. Daga cikin waɗannan, shida suna da alamun bayyanar da rashin cututtuka kuma ba su daina fara cin abinci marasa cin abinci. Daya ya kara yawan lalacewa a cikin zubin ciki (daga Marsh I zuwa Marsh IIIa) kuma ya so ya fara cin abinci.
Masanan binciken sun ƙayyade cewa marasa lafiya da basu hadu da ka'idojin cutar Celiac duk da haka sun kasance suna jin dadi sosai kuma sun amfana daga cin abinci maras amfani.
"Ko da yake Marsh I-II cutar ba za a iya lasafta shi azaman cizon celiac ba, marasa lafiyar bayyanar cututtuka a gabatarwa da kuma ingantaccen bayyanar cututtuka a yayin GFD [cin abinci maras amfani], tare da ko ba tare da cigaba da cutar labarun tarihi ba, yana goyon bayan zaton wadannan marasa lafiya suna kula da maniyyi kuma suna iya tabbatar da magani tare da GFD, "in ji masu bincike.
Gluten Sensitivity May Affect Daya a 14 Mutane
Gluten hankali (ko rashin haƙuri) na iya shafar kusan 6% zuwa 7% na yawan jama'a, in ji Dr. Fasano. Wasu a cikin likitocin kiwon lafiya sun sanya adadin mutanen da ba su da karuwanci - mafi girman mutane - na gani kimanin kashi 10% zuwa 50% na yawan jama'a.
Kara karantawa a kan waɗannan lambobi: Yaya Mutane da yawa Sun Gana Rayuwa Gluten?
Yana da wuya a gaya mana mutane da yawa suna da hankali sosai ba tare da ƙarin bincike ba kuma sun yarda da gwaje-gwaje masu guba . Amma a bayyane, ko da lambobi suna a kan ƙananan ƙananan, za su ƙidaya adadin celiacs, waɗanda suka kasance kusan kashi 1 cikin dari na yawan jama'a.
Mutane da yawa a cikin yankin celiac / masauki sunyi imani da cewa cututtuka da gubar dalma suke haifar da kansu a kan "yanayin bambance" na yanayin alkama, tare da cututtukan Celiac, gluten ataxia (cututtukan ƙwayoyin cuta daga gluten) da kuma kulawa da guguwa duk suna fadowa a wani wuri.
Dokta Fasano ya ce mataki na gaba shine ganewa na alamar nazarin halittu, ko "biomarker," don kulawa da gugu . Gwajin gwajin da za a yi kamar yadda yake faruwa a yanzu, kuma Dr. Fasano ya ce yana da "m" masu bincike za su nuna cewa mai ba da labari. Daga can, masu bincike zasu iya ci gaba da gwaji don gano hankali mai guba - wanda zai iya samun kasuwanci a cikin shekaru masu zuwa.
> Sources:
> Bernini P. et al. Shin marasa lafiya da cututtuka na Celiac suna da kyau? Amsa na Metabonomics. Journal of Proteome Research. Aka buga a ranar labaran 19 ga watan Nuwamban 2010., DOI: 10.1021 / pr100896s.
> J. Biesiekierski et al. Gluten yana haifar da cututtukan cututtuka a cikin wadanda ba tare da cutar Celiac ba: Wani abu mai mahimmanci wanda aka sa ido a wuri-wuri. Jaridar Amirka ta Gastroenterology ci gaba da layi, Janairu 11, 2011; Doi: 10.1038 / ajg.2010.487.
> A. Fasano et al. Bambanci na Gut Permeability da Mucosal Immune Gene Expression a cikin biyu Gluten-Associated Conditions: Celiac cuta da Gluten Sensitivity. BMC Medicine 2011, 9:23. Doi: 10.1186 / 1741-7015-9-23.
> Fasano A. et. al. Abun Cutar Gluten-related: Dismissive on New Nomenclature da Classification. BMC Medicine. Medicine na BMC 2012, 10:13 pm: 10.1186 / 1741-7015-10-13. An buga: 7 Fabrairu 2012
> Tursi A. et al. Maganar Bayyanawa da Tarihi ga Abincin Gluten-free a cikin marasa lafiya tare da Interopathy Borderline. Jaridar Clinical Gastroenterology. 2003 Jan; 36 (1): 6-7.