Amfani da Marsh Scores don Tattaunawa Celiac cuta

Marsh yawancin lalacewa na ciki daga cutar celiac

Idan an gwada ku don cutar cutar celiac , likitanku zai iya yin lalacewa da biopsy don ganin ko yatsun ku ya lalace ta hanyar alkama , wani sinadaran da ake samu a alkama, da sha'ir, da hatsin rai. Kwararka zai yi amfani da kayan aikin likita, wanda ake kira endoscope, tare da karamin kyamara don duba kai tsaye a tsarin tsarinka na sama, kuma zai dauki ƙananan samfurori na nama daga murfin ƙananan hanji.

Bayan binka, mai ilimin likita zai duba samfurorin jikinka don ganin idan akwai lalacewar alwala. Wannan masanin ilimin likita zai fahimci yanayin wadannan samfurori bisa tsarin da aka kwatanta da Marsh Score. Matsayin Marsh ɗinka zai tantance ko an gano ku tare da cutar celiac, da kuma yadda lafiyarku ta kasance.

Celiac cutar ba shine kawai yanayin da zai iya haifar da wasu daga cikin wadannan canje-canje, wannan shi ya sa biopsy ne kawai daya daga cikin gwaje-gwajen gwaje-gwaje da shawarar domin cutar celiac-ko da yake an dauke biopsy "ma'auni na zinariya" don ganewar kwayar celiac. Sakamakon gwajin jini na celiac da kuma kyakkyawar amsawar mutum ga abincin mai cin abinci ba tare da yalwaci ba zai iya taimakawa wajen samun ganewar asali.

1 -

Mataki na 0

Wannan hoton ne a lokacin da aka kawo karshen endoscopy, yana nuna wani ƙwayar ƙwayar ƙwayar da ta dace tare da cike da lafiya. Tun da rufin intestinal ya bayyana na al'ada, yana da wuya cewa mutum yana da cutar celiac.

A wannan yanayin, za'a samo samfurin biopsy a matsayin Marsh Stage 0, wanda aka fi sani da "mataki na baya-baya". an kira shi "pre-infiltrative" saboda lymphocytes basu riga sun fara motsa cikin, ko "infiltrate," da rufi na hanji.

2 -

Yanayi 1 da 2

Matsayi na farko na Marsh yana nufin sel a kan farfajiya na intestinal, wanda aka sani da kwayoyin halittu, suna da karin kwayoyin lymphocytes, jini mai tsabta, daga cikinsu fiye da al'ada.

A cikin ƙwayar ƙwayar ƙwayar halitta, babu ƙwayar lymphocytes fiye da 100 na 100, amma a cikin lokuta masu tsinkaya 1, akwai fiye da haka. Idan kana da mataki na 1, za a iya karanta labarun likitancinka "ƙananan lymphocytes intraepithelial."

Celiac cutar ba shine kawai yanayin da zai iya haifar da karuwa a cikin kwayar cutar lymphocytes. Kuna iya samun karin lymphocytes idan kuna da ciwo na jini, Sjogren's syndrome, da sauran abincin abincin. Cutar da kwayoyin da ake kira Helicobacter pylori (wanda aka danganta da ulcers), da kuma yin amfani da cututtukan da ake kashewa irin su aspirin da ibuprofen, zasu iya haifar da wannan.

Mutanen da ke fama da cutar celiac wadanda ke bin abinci marar yisti , dangin mutanen da ke fama da cututtukan Celiac, da kuma mutanen da ke da dermatitis herpetiformis , wani mummunan raguwa wanda aka ɗauka shine bayyanar fata na cututtukan Celiac, na iya samun mataki na 1 Marsh Ci.

Tare da mataki na 2, zaku ga karin lymphocytes fiye da na al'ada da kuma manyan matsaloli fiye da na al'ada tsakanin villi na intestinal. Wadannan cututtukan ana kiransu "crypts," kuma ana kiran su "hyperplastic" mafi girma-da-al'ada crypts, don haka idan rahotonka na likitancinka ya biyo bayan jikinka ya ce kana da "crypts hyperplastic crypts" ko "hyperplasia crypt", yana nufin cututtukan da aka gani a cikin jikinka na biopsy sun fi girma fiye da yadda za su kasance cikin al'ada na hanji.

Sashe na 2 shine kyawawan rare-an fi gani a cikin mutane waɗanda ke da dermatitis herpetiformis.

_{Wannan hoto ne daga Figure 1b na Ludvigsson et al. BMC Gastroenterology 2009 9:19. Doi: 10.1186 / 1471-230X-9-19. An samo hotunan hotunan daga Farfesa Åke Öst, shugaban da ya jagoranci Cibiyar Gudanar da Ƙungiyar Ƙwararrun Ƙwararren Ƙwararrun Ƙasar ta Sweden don ƙananan ƙwayoyin cutar.}

3 -

Sashe na 3

Yawancin likitoci ba za su gwada cututtukan Celiac ba har sai jinin jikinka zai kai mataki na 3. A cikin wannan mataki, canje-canje na mataki 2 sun kasance - more lymphocytes fiye da al'ada da kuma girma-fiye da-al'ada depressions - da shrinking da flattening na hanji villi , abin da aka sani da atrophy villous.

Sashe na 3 yana da abubuwa uku:

• Ƙananan ƙwayar cutar (Stage 3a): Gumunku na ciki yana har yanzu, amma sun fi ƙanƙan
• Subtotal villous atrophy (Mataki na 3b): Maganin hankalinku na hanzari ya karu sosai
• Kwancen gurasar villous (Mataki 3c)

Yawancin mutanen da aka gano da cutar Celiac suna da matsayi na 3 Marsh.

_{Wannan hoto ne daga Figure 1c na Ludvigsson et al. BMC Gastroenterology 2009 9:19. Doi: 10.1186 / 1471-230X-9-19. An samo hotunan hotunan daga Farfesa Åke Öst, shugaban da ya jagoranci Cibiyar Gudanar da Ƙungiyar Ƙwararrun Ƙwararrun Ƙungiyar ta Ƙasar ta Ƙananan Ƙananan Ƙwayar Cutar.}

4 -

Mataki na 4

Mataki na 4 shine mafi matukar ci gaba kuma ba'a ganin duk abin da sau da yawa. A cikin mataki na 4, an lazimtar da kullunku (an ƙetare) da ƙyamar da ke tsakanin su (crypts).

Sashi na 4 shine mafi yawancin tsofaffi tare da cutar celiac. Idan maki Marsh ya zama mataki na 4, zaka iya samun haɗari mafi girma ga rikitar cutar celiac, ciki har da lymphoma.

Acknowledgment:

_{Wannan hoto ne daga Figure 1d na Ludvigsson et al. BMC Gastroenterology 2009 9:19. Doi: 10.1186 / 1471-230X-9-19. An samo hotunan hotunan daga Farfesa Åke Öst, shugaban da ya jagoranci Cibiyar Gudanar da Ƙungiyar Ƙwararrun Ƙwararrun Ƙungiyar ta Ƙasar ta Ƙananan Ƙananan Ƙwayar Cutar.}

5 -

Kalma daga

Masu amfani da gastroenterologists sunyi amfani da Marsh scores don tantance lalacewar ƙananan ƙwayar hanji daga cutar celiac. Matsayi na Marsh zai tantance ko kuna da cutar celiac, da kuma yadda ya lalata ciwon hankalin ku.

Wannan jagorar zuwa matakan Marsh matakai zai iya taimaka maka fassara fassarar daga jikinka na jikin mutum. Duk da haka, idan kuna da matsala fahimta, kada ku ji tsoron magana da likitan ku game da abin da ake nufi. Kuma ku tuna: da zarar kun fara cin abinci marasa cin abinci, har ma da lalacewa maras kyau ya fara fara warkar.

> Sources:

> Ludvigsson JF et al. Amincewa nazarin villous atrophy da kananan na hanji kumburi a Sweden biopsy rajista. BMC Gastroenterology . 2009; 9: 19.

> Snyder CL, Young DO, Green PHR, Taylor AK. GeneReviews: Celiac cuta. 2009.

> Hill ID et al. Sharuɗɗa don ganewar asali da kuma kula da cututtukan Celiac a cikin yara: shawarwari na Cibiyar Arewacin Amirka ta Fediatric Gastroenterology, Hepatology da Nutrition. Journal of Pediatric Gastroenterology and Nutrition. 2005; 40: 1-19.

> Magungunan Medicine na Stanford: Tsarin Celiac.