Menene ma'anar idan kana da cutar sankarar barga mai girma (APL) kuma yaya aka bi ta?
Bayani
Murar cutar sankarar mikiya mai mahimmanci (APL) wani sashi ne na cutar cutar sankarar mutelogenous (AML) , ciwon daji na jini. Hakanan zaka iya ji shi ake kira M3 AML. A Arewacin Amirka, APL na kimanin kashi 10% na duk lokuta na AML. A Italiya da yankunan Kudancin Amirka, APL na iya wakiltar kusan 65% na lokuta.
Yana faruwa daidai a cikin mata da maza, kuma shekarun shekarun farko na shekaru 40.
Duk da yake yana da irin wannan a hanyoyi da yawa zuwa ga wasu subtypes, APL ya bambanta kuma tana da tsarin kulawa na musamman. Sakamakon maganin APL yana da kyau, kuma an dauke shi mafi yawan maganin cutar sankarar bargo. Cure rates ya kasance kamar yadda 90%.
Kwayoyin cutar sankarar rigakafi da cututtuka na gargajiya da sauri (APL)
Rashin ƙwayar halittar kwayar halitta ko maye gurbi wanda aka fi gani a DNA na kwayoyin cutar sankarar bargo shine haɗuwa tsakanin chromosomes 15 da 17. Wannan yana nufin cewa wani ɓangare na chromosome 15 ya karya, kuma an musayar tare da wani ɓangare na chromosome 17. Wannan maye gurbi yana haifar da samar da wani sinadaran da ke haifar da ci gaban kwayar jini don samun "makale" a lokacin da aka yi amfani da jini, lokacin da jini mai tsabta yaro ne sosai.
Mene Ne Masu Aminci?
Wadanda suka fada cikin layi a cikin ci gaba da waɗannan nau'in jini, tare da '' jarirai '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '.
Kwayoyin cutar sankarar bargo ne da za'a iya kwatanta da su. Suna kallo kamar manya, amma ba za su iya samun aikin yi ba, suna biyan takardar kudi, ko motar mota, ko yin ayyukan yau da kullum na cikakkun mutane. Bugu da ƙari, jini ƙwayoyin jini sunyi maƙasudin ci gaba don aiwatar da matsayin cikakkun kwayoyin jini a jiki.
Alamai da cututtuka
Abokan da ke tare da APL sun nuna alamun wariyar launin fata kamar sauran nau'o'in cutar sankarar sankarar myelogenous (AML). Yawancin alamun cutar sankarar bargo ne sakamakon sakamakon ciwon daji wanda ke "juyewa" daga kasusuwan kasusuwa da kuma tsangwama tare da samar da kwayoyin halitta na al'ada, sassan jinin lafiya, kukan jini da kuma plalets. Wadannan alamu da bayyanar cututtuka sun haɗa da:
- Samun žarfin makamashi, ko jin gajiya duk lokacin
- Jin kadan lokacin numfashi lokacin yin aiki na yau da kullum
- Pale fata
- Labarai maras kyau
- Ƙãra waraka lokacin cuts da bruises
- Kasusuwa ko kasusuwa
- Difficulty "fada kashe" cututtuka
Bugu da ƙari ga waɗannan alamun AML, marasa lafiya APL sun nuna wasu alamun bayyanar . Za su sau da yawa:
- Yi fama da matsaloli mai tsanani kamar jini, hanci, jini a cikin fitsari ko ƙuƙwalwa. 'Yan mata da mata tare da APL zasu iya lura da lokacin haɗari.
- Bugu da kari, akwai sau da yawa mahaukaci, ƙin jini da yawa.
Sakamakon cutar sankarar bargo na iya zama m, kuma yana iya kasancewa alamun wasu, yanayin da ba zai yiwu ba. Idan kun damu da lafiyar ku, ko kiwon lafiya na ƙaunataccena, yana da kyau mafi kyau don neman shawara na likita.
Jiyya
Yin jiyya na cutar cutar sankarar bargo (APL) ya bambanta da sauran nau'in cutar sankarar bargo, don haka gane shi yana da muhimmanci.
Yawancin marasa lafiya APL sune da farko tare da dukkanin sassan retinoic acid (ATRA), wani nau'i na musamman na bitamin A. ATRA farfadowa ne a cikin abin da yake ɗaukar da kwayar cutar sankarar rigakafi na promyelocytic. kwatanta a cikin girma girma (da kyau, a kalla wani lokaci). Wannan lokaci na magani ana kiransa "induction."
Duk da yake ATRA na iya samun haƙuri na APL zuwa gafara ta wajen tura dukkanin kwayoyin cutar sankarar bargo a cikin balaga, ba zai iya warkar da tushen cutar sankarar bargo ba. A sakamakon haka, sakamako mai tsawo na magani zai inganta yayin da likitoci sun ƙara wani chemotherapy .
Wannan fuskar magani tana kiransa "ƙarfafa."
Bayan shan magani, mutane sukan cigaba da ci gaba a kan ATRA a kalla a shekara, wasu lokuta ana hade da wasu magunguna. Wannan lokacin na ƙarshe na magani ana kiransa "kiyayewa."
Idan cutar sankarar bargo ba ta amsa ATRA da chemotherapy, ko kuma idan ya dawo, za a iya magance APL tare da arsenic trioxide (ATO).
Faɗakarwa
Jiyya na APL ya ci nasara a cikin mafi yawan lokuta.
Ciyar da goyon baya
Kodayake cutar cutar sankarar bargaɗi mai tsanani na da kyau sosai, a kalla game da cutar sankarar bargo, "samun can" zai iya zama da wahala da saukowa. Ku shiga wurin iyali da abokai . Kada ka damu game da bukatar taimako da samun taimako a wannan mataki a rayuwarka. Kuna iya mamakin yadda ba kawai taimaka maka ba, yayin da wasu ke taimakawa, amma yana kawo farin ciki a gare su. Bincika waɗannan shawarwari kan yin maganin cutar sankarar jini da lymphoma .
Yi lokaci don koyi game da mai tsira. Lokacin da maganin ciwon daji ya ƙare, maimakon mawuyacin hali, mutane da yawa suna jin damuwa. Ra'ayin sakamako mai tsanani na jiyya da kuma lokacin da aka yi amfani da shi a kan motsawar motsa jiki na ciwon daji zai iya barin ku mamaki idan za ku sake jin dadin al'ada. Tambayi taimako, kuma kada ku yarda da "sabon al'ada". Akwai abubuwa da yawa da za a iya yi domin taimakawa masu tsira da ciwon daji suyi bunƙasa. Kuma kar ka manta cewa, a wasu lokuta, mai kyau zai iya samuwa daga ciwon daji. Nazarin na ainihi ya gaya mana cewa ciwon canji ya canza mutane a hanyoyi masu kyau , ba kawai mummuna ba.
Sources
Cibiyar Cancer na Amurka. Jiyya na m promyelocytic (M3) cutar sankarar bargo. Updated 02/22/16. http://www.cancer.org/cancer/leukemia-acutemyeloidaml/detailedguide/leukemia-acute-myeloid-myelogenous-treating-m3-leukemia
Jurcic, J., Soignet, S., Maslak, P. Bincike da Jiyya na Acute Promyelocytic cutar sankarar bargo. Rahoton Kayan Lafiya na Yanzu na 2007. 9: 337-344.
Lemons, R., Keller, S., Gietzen, D., Dufner, J, Rebentisch, M., Feusner, J., Eilender, D. Acute Promyelocytic Leukemia Labari na Ilimin Harkokin Ilimin Harkokin Ilimin Kimiyya / Ilimin Halitta 1995. 17: 198- 210.
Sanz, M. Jiyya na Acute Promyelocytic cutar sankarar bargo. Ƙungiyar Amirka ta Harkokin Ilmin Halitta 2006. 147- 155.
Wiernik, P., Gallagher, R., Tallman, M. "Acute Promyelocytic Lungmia" a Wiernik, P., Goldman, J., Dutcher, J., Kyle, R. (eds.) (2003) Blood- 4th ed. New York: Jami'ar Cambridge Jami'ar.