Nilotinib da Links tsakanin cutar sankarar bargo da Parkinson's

Cututtukan Parkinson na rinjayar kwakwalwa da kwayoyin jijiyar jiki kuma yawanci yana haifar da matsaloli tare da ƙungiyoyi na muscle; cutar sankarar bargo ne irin ciwon daji da ke shafar kututture da jini. Kwayar Parkinson na da wuya a yara; yayin da cutar sankarar ita ce mafi yawan ciwon daji na yara. Ta yaya wadannan cututtuka biyu da suka bambanta zasu iya samun wani abu?

To, mutanen da ke da kwayar cutar Parkinson da mutanen da ke fama da cutar sankarar barkewa suna da yawa a na kowa-nauyin kula da cutar. Amma a hankali, duk da haka, wallafe-wallafe na kimiyya yana ba da dama ga wasu wanda zai iya zama mai sha'awa ga waɗanda ke neman hanyar da ta dace tsakanin waɗannan cututtuka biyu.

Lurar cutar sankarar bargo yana bayyana don rage cututtukan cututtuka na Parkinson

Tasigna (nilotinib) wani magani ne da aka yarda don magance wasu cutar sankarar bargo. Bisa ga ƙananan ƙungiyar mahalarta nazarin, nilotinib ya bayyana ya rage bayyanar cututtuka a cikin mutanen da ke fama da cutar Parkinson tare da lalata ko Lement jiki.

Bisa ga rahoton NPR, wani gwajin da aka yi wa marasa lafiya 12 da aka bai wa nilotinib sun gano cewa motsi da aikin tunani sun inganta a cikin dukan mutane 11 da suka kammala gwajin watanni shida. Masu bincike sun ruwaito wadannan binciken a Kamfanin na Neuroscience a Birnin Chicago. Binciken ƙananan binciken, ba a tsara shi don auna tasiri ba kuma babu lissafin sakamako na placebo.

Duk da haka, wadannan binciken sun kasance masu ban sha'awa sosai kuma zasu kara zurfafa bincike.

Nilotinib na cikin ƙungiyar magungunan da aka sani da masu hana hawan kinase. Mafi mahimmanci, Nilotinib mai hanawa ne na BCR-ABL kinase. Kinases da wani rukuni na enzymes, GTPases, ba wai kawai suna cikin rikici ne ba, amma sun haɗa da wasu cututtukan mutane kamar ciwon daji da kuma mummunan yanayi.

Duk da yake ba a tsara miyagun ƙwayoyi ba saboda cutar ta Parkinson, ba abin da ba zai iya tsammani ba a kimiyya ba cewa zai iya samun tasiri mai amfani ba don wannan cuta.

Ruwan ruwan inabi mai gurɓata da aka haɗa zuwa biyu

Wani binciken da aka wallafa a cikin watan Agustan 2014 na mujallar "Lafiya ta Mahalli," ya yi amfani da gaskiyar cewa wasu ruwan sha a Amurka Marine Corps Base Camp Lejeune, North Carolina, an samu gurbatawa ta hanyar raguwa a shekarun 1950 zuwa 1985. A rukuni na masu binciken sunyi nazarin sakamakon wannan hadarin ta hanyar kwatanta dalilai na mutuwa tsakanin ma'aikata a Camp Lejeune tare da Camp Pendleton, inda ruwan yake tsabta.

Yana da kalubalanci don warware matsalar da tasiri yayin da kake duban baya, kuma an fassara sakamakon da aka samu daga wannan nau'in binciken tare da taka tsantsan. Duk da haka, a cikin wannan binciken, kamuwa da cututtuka da yawa sun hada da ciwon daji, cutar sankarar bargo, myeloma, da cutar Parkinson a cikin ma'aikatan da aka bayyana a Camp Lejeune.

Bayyana ga Kwayoyin Magungunan Ƙwayoyi da aka haɗa zuwa Dukansu

Mafi yawan lokuta da cututtukan Parkinson da cutar sankarar barkewar an yi imani da su ci gaba ne a hanyar da take da yawa, wanda zai iya kasancewa tare da wasu muhalli daban-daban da ke tattare da muhalli da kuma wasu nau'ikan kwayoyin halitta.

Don nazarin cigaba da irin wannan cututtuka game da wani abu, kuma yin haka neman baya a lokaci yana da kalubale. Duk da haka, akwai goyon baya ga hanyar haɗi tsakanin magungunan kashe qwari, herbicides da toxins da kuma cutar sankarar bargo da cutar Parkinson. Bisa ga binciken da aka yi a cikin watan Mayun 2013 na mujallolin Neurology , wallafe-wallafe na kimiyya sun yarda da cewa tsinkayen kwayoyin cutar magungunan kashe magungunan magungunan kwayoyin cutar sune mawuyacin hali ga Parkinson, amma karin bincike ya zama dole don tabbatar da dangantaka da tasiri. Paraquat (paraquat dichloride, ko methyl viologen), alal misali, wani maganin herbicide wanda aka sanya shi a matsayin wani hadarin haɗari ga cutar Parkinson.

Haka kuma, wata ƙungiyar masu bincike a Costa Rica ta yi ƙoƙari su yi nazarin dangantaka tsakanin iyaye da suka kamu da cutar shan magani da kuma hadarin cutar sankarar ƙananan yara a cikin 'ya'yansu. Duk da yake ba za su iya cire yiwuwar yawancin jinsunan da suka bincikar ba, sun ga yadda ake kara yawan ƙwayar cutar sankarar ƙanƙara da yaduwar cutar pesticide-musamman ma a cikin mahaifiyar da ke dauke da magungunan kashe qwari a lokacin farko da na biyu na ciki.

Sources:

Bove FJ, Ruckart PZ, Maslia M, Larson TC. Nazarin mutuwa na mutuwa na kamfanonin farar hula da aka fallasa a ruwan sha mai gurɓata a Cibiyar Leken asiri ta USMC: binciken da aka yi a kan jarrabawa. Lafiya ta muhalli. 2014; 13: 68.

Cohn P, Klotz J, Bove F, Fagliano J. Yin ruwa da ruwa da kuma cutar da cutar sankarar bargo da kuma Hodgkin lymphoma. Game da Harkokin Lafiya.

Monger P Wesseling C, Guardado J, et al. Hanyoyin da ake yi wa iyaye a fannin magungunan kashe qwari da haɗarin cutar sankarar ƙananan yara a Costa Rica. Scand J aiki game da lafiya. 2007; 33 (4): 293-303.

Kamel F. Hanyoyi daga magungunan kashe qwari zuwa Parkinson. Kimiyya . 2013; 341: 722-723.

Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Cutar ilimin cututtuka da kuma ilimin ilimin cututtuka na kwayar cutar Parkinson: nazari akan shaidar. Eur J Epidemiol . 2011; 26 (Sanya 1): S1-S58.

Pezzoli G, Cereda E. Bayyana ga magungunan kashe magungunan kashe magungunan magungunan magunguna ko kuma hadarin cututtuka na Parkinson. Ma'anar ilimin halitta . 2013; 80: 2035-2041.

NPR. Shin Can Cancer Drug Reverse Lafiya ta Parkinson Da Dementia?

Hong L, Sklar LA. GTPases na cike da cutar a cikin cututtukan Parkinson: kwatanta da tarihin hanyar gano kwayoyin cutar kinase da kuma hanyoyi. Matsakaici a Neuroscience Ƙunƙasa . 2014; 7: 52.