Magungunan maganin masu ciwo da ƙwayoyin cutar marasa ciwon ƙwayoyin ƙwayoyin cuta, waɗanda aka fi sani da NSAIDs, sune wasu magunguna mafi magungunan, musamman ma marasa lafiya da ke da alaƙa irin su arthritis, bursitis, da tendonitis. Wadannan magunguna suna samuwa a kan kaya (misali Ibuprofen, Motrin, Aleve) ko a matsayin takardun magani (misali Celebrex, DayPro, Relafen).
Hannun NSAID suna da tasiri a duka raunin zafi (analgesia), kuma don rage kumburi (anti-inflammatory).
Yadda suke aiki
Magunguna da ke aiki don rage ƙonewa zo a cikin manyan manyan sassa biyu:
- Steroids (misali Cortisone )
- Magungunan anti-inflammatory marasa ciwon steroidal (NSAIDs)
Magungunan kwayoyi da ake amfani da su wajen maganin kumburi su ne masu banbancin yanayi na jikin mutum wanda ake kira cortisol. Haka kuma akwai wasu nau'o'in steroid (ciki har da cholesterol da jima'i na hormones), amma wannan nau'i na uku shine maganin maganin mai ƙin ƙwayar cuta. Za a iya ba da magungunan maganin magungunan kwakwalwa ta hanyar magana, a cikin tsari, ko kuma yadda ake amfani da su , kamar yadda ake amfani dashi a cikin kothopedics.
NSAIDs na aiki don toshe sakamakon wani enzyme da ake kira cyclooxygenase. Wannan enzyme yana da muhimmanci a cikin aikin jikin ku na prostaglandins. Yana da prostaglandins da ke haifar da kumburi da ciwo a cikin yanayin irin su arthritis ko bursitis. Saboda haka ta hanyar tsangwama tare da aikin cyclooxygenase, zaku rage yawan samar da prostaglandins, kuma rage yawan ciwo da ƙumburi da suka shafi waɗannan yanayi.
M, daidai?
To, akwai ƙarin zuwa gare ta. Prostaglandins kuma suna da wasu muhimman ayyuka a cikin jiki. Wani irin prostaglandin (akwai nau'o'in da yawa) yana taimakawa cikin ciki tare da ruwa mai karewa (wanda ake kira mucosa na ciki). Lokacin da mutane ke daukar magunguna NSAID, samar da wannan ruwa mai karewa zai iya raguwa, kuma wasu mutane suna fuskantar haɗari don bunkasa ciki na ciki.
Sabuwar / Dokar NSAIDs Better?
A cikin shekaru da suka wuce, wasu magunguna sun zo a kasuwa; Wadannan ana kiransu masu haɓaka COX-2 . Ka tuna, duk NSAID na aiki da cyclooxygenase (COX). Tsarin al'ada NSAIDs (misali Ibuprofen, Motrin, Aleve) aiki akan duka COX-1 da COX-2. COX-1 da COX-2 su ne nau'i-nau'i na cyclooxygenase wadanda ke aiki a jikinka. Sabbin magunguna (misali Celebrex) suna aiki ne da COX-2, kuma suna ba da damar COX-1 aiki akai-akai. Saboda COX-1 yana da mahimmanci wajen samar da murfin karewa a cikin gut (mucosa na ciki), waɗannan wadanda ake kira NSAIDs suna da ƙananan haɗarin haifar da ulcers.
Wancan ya ce, ba a nuna sabon sababbin NSAID don yin aiki mafi kyau ba game da enzyme COX-2. Saboda haka, masu maganin COX-2 suna da amfani da yiwuwar samun sakamako mai yawa, amma ba dole ba ne mafi kyawun taimako daga bayyanar cututtuka.
Hanyoyi na NSAIDs
Za a iya samun NSAID a kan-counter, amma hakan ba yana nufin sun kasance tare da fitarwa masu tasiri. Mafi rinjaye na gefe-halayen shine haushi na ciki. Dalilin wannan yana zaton shine saboda sakamakon da ke ciki. Idan wahalar yana da tsanani, zai iya haifar da ciwon jini , da kuma matsaloli mai tsanani.
Kafin ka fara shan magunguna NSAID ya kamata ka yi magana da likitan ka. Tabbatar sanar da likitan ku game da wasu matsalolin kiwon lafiya da kuke da shi, musamman hawan jini, fuka, koda, ko matsalolin ciki. Bugu da ƙari, bari likita ya san wasu magunguna da za ku iya ɗauka, kuma idan kuna da wani abin da ake ganowa zuwa magunguna.
Kada a yi amfani da NSAIDs idan:
- Kuna da ciki
- Kai ne nono
- Kana da tarihin ciki na ciki
- Kana shan shan magani na jini
Dole ne a yi amfani da NSAIDs kawai a karkashin CLOSE duba likita idan:
- Kana da fuka
- Kuna da matsalolin hanta
- Kuna da matsaloli na zuciya
- Kuna da matsaloli na koda
Ƙashin Gida: Shin Tsaro NSAIDs ne?
Magunguna marasa maganin ƙwayoyin cuta marasa lafiya suna da lafiya sosai kuma zasu iya tasiri sosai. Sau da yawa ana iya samun sakamako ta hanyar yin amfani da tsawon lokaci kaɗan. Wannan ya ce, wadannan magunguna suna da tasiri masu illa kuma baza su iya amfani da su ba. Duk da yake mafi yawan mutane da yanayin da ke haifar da ƙonewa zai iya samun NSAIDs don taimakawa, ya kamata ku tattauna tare da likita idan kuna tunanin farawa ɗaya daga waɗannan magunguna.
Sources:
Berger, RG "Harkokin Kwayoyin Kwayoyin Kwayoyin Halitta marasa Kwayoyin Halitta:" Amincewa da Hakki "J. Am. Acad. Ortho. Surg., Oktoba 1994; 2: 255 - 260.
van Tulder MW, et al. "Magungunan anti-inflammatory marasa cututtuka don rashin jinƙan ciwo A cikin Cochrane Database of Review System 2006 Tambaya 1.