Rigar Mutuwar Mu'ujiza
Prostaglandins sune kwayoyin hormones da ke yin tasiri sosai a kan matakai na jiki a jikinka. Suna da tasiri mai kyau da kuma mummunar tasirin lafiyarka. Watau ma'anar, prostaglandins suna tallafawa homeostasis, amma har ma sun inganta tsarin tafiyar da cutar.
Makasudin
Wadannan abubuwa masu kankanin sun kasance daga fatty acid, kuma suna taka muhimmiyar rawa a ayyuka da yawa.
Wasu daga cikin waɗannan ayyuka sun haɗa da, misali, vasodilation da vasoconstriction. Vasodilation da vasoconstriction su ne, bi da bi, da atomatik aiki na jini jini bude da rufe. Sauran sun hada da bronchostriction, wanda shine rikitarwa na hanyoyi na iska, yaduwar jini, maganin yaduwar jiki, zazzabi, da kuma kula da kyallen takalma irin su murfin ciki.
Tare da abubuwan da ke cikin jerin da ke sama, prostaglandins suna tasiri matakan zafi da kuma daidaita kumburi, ƙwayoyin jiki guda biyu da ke shafi kusan kowane mutumin da yake hulɗa da wuyansa ko baya.
Bisa ga bayanin edita a 2003 a cikin yanayin Halittar Halitta , akwai kimanin nau'in prostaglandins 24.
Magunguna Wannan Target Prostaglandins
Saboda prostaglandins suna da muhimmiyar gudummawa wajen farawa da ci gaba da ƙonewa, yawancin ƙwayoyi sun ɓullo a cikin shekaru don magance aikin su. Wadannan magungunan suna da tasiri sosai da mahimmanci, kuma mutane a duk fadin duniyar da kuma daga cikin tsufa sun juya zuwa gare su akai akai.
A zamanin d ¯ a, an yi amfani da hawan willow don taimakawa zafi da kuma rage yawan zazzabi, kuma a kwanakin nan masu yawan gaske suna bada shawarar wannan shuka ga abokan cinikin su. A cikin shekarun 1820, mai aiki na willow ya ƙaddara ya zama salicylic acid. Amma lokacin da marasa lafiya ke fama da matsalolin ciki, ciki har da zazzabin da zubar da jini, sakamakon sakamakon salicylic acid, acetylsalicylic acid ya fara amfani dashi a wurinsa.
A cikin shekarun 1890, acetylsalicylic acid ya fara farawa a kasuwar aspirin ta hanyar kamfanin da aka sani sannan kuma a yanzu Bayer.
COX Inhibitor Drugs
A cikin shekarun 1960 an samo wani nau'i na magungunan da ake kira acid phenylolkanoic don rage ƙonewa da ciwo. Wadannan albarkatu suna yin haka ta hanyar kulle enzyme cyclooxygenase, ko COX. (COX enzymes sukan yi aiki a farkon tsara prostaglandins.) Rubutun "Painkillers and prostaglandins" sun gano cewa an gano 3 enzymes guda COX: COX 1 wanda ke kare yankin GI, COX 2, wanda ke taka rawa wajen ƙonewa, zazzaɓi , da zafi, da kuma COX 3 wanda aka samo su a cikin kwakwalwa. Sanannun masu cin hanci na COX (wanda yake a kasuwa yanzu) don ciwo da ƙumburi-irin da mutane suke da wuyansa ko ciwon baya - sun hada da aspirin da ibuprofen ( Advil ). Aspirin da Advil sun hana duka COX 1 da COX 2 enzymes. Abubuwa masu illa daga wadannan magunguna sune ulcers da zub da jini a cikin rufin ciki.
Advil ya zo tare da hadari don ciwon zuciya da bugun jini, rashin alheri.
A hakika, banda aspirin, duk wadanda basu da kwayar cutar shan-jiji (NSAIDs) sun zo tare da FDA "black-akwatin" gargadi cewa shan magani yana kawo hadarin cutar cututtukan zuciya.
Kuna iya tunawa da Vioxx da Bextra , masu saurin ciwo mai zafi da aka cire daga kasuwa a shekara ta 2004. Ayyukan wadannan kwayoyi sun hana kawai COX 2 enzyme; saboda haka, an san su ma'anar CO2 2. Abinda suka amfana shi ne cewa abubuwan da ke cikin alakar dake ciki sun tafi; matsalar ita ce, a lokaci guda waɗannan kwayoyi sun ji dadin matsayinsu a kasuwar, an tabbatar da cewa masu hana masu caba COX-2 sun kara hadarin mummunan tsanani har ma da cututtukan zuciya da kisa.
A watan Satumbar 2004, Merck ya ja hankalin Vioxx daga kasuwa. A cikin watan Afrilu 2005, FDA ta umurci magungunan miyagun ƙwayoyi Pfizer don cire Bextra daga kasuwa amma a yarda Celebrex (Celecoxib) ya kasance, inda har yau.
Kalma daga
An san cewa kumburi yana tushen tushen cututtuka na zamani, ciki har da ciwo mai tsanani. Har ila yau an san cewa shan shan magani don magance matsalolin da ke haɗuwa da ƙonewa na iya zama tare da sakamakon illa, wasu daga cikinsu na iya zama mai tsanani, hakika.
Don haka, yawancin masu samar da lafiya, marasa lafiya, da masu kare lafiyar likita sunyi shawara ko bin wani cin abinci mai cin hanci da rashawa. Wani labarin da aka wallafa a Harvard Mata Health Watch ya ruwaito cewa yawancin bincike sun nuna abinci zai iya samun sakamako mai ƙyama.
Sanin wadanda zasu iya taimakawa wajen samar da tushen abincin da za su iya taimaka wajen yaki da kumburi.
Wasu mutane sun dauki kayan shafa mai ƙin kumburi ko kariyan su , kamar willow haushi, wadda aka tattauna a sama.
> Sources:
> Edita. Painkillers da prostaglandins. Binciken Halittar Halitta. 2003
> Harvard Lafiya ta Mata. Abincin da ke fama da kumburi Agusta 2017.
> Ricciotti, E., PhD, FitzGerald, Garret A., MD. Prostaglandins da kumburi. Arterioscler Thromb Vasc Biol. Mayu 2011.