Technivie (ombitasvir + paritaprevir + ritonavir) yana amfani da maganin da ake amfani dashi don maganin cutar rashin lafiya C (HCV) . Wadannan jami'o'i guda uku da suka hada da Technivie sun hada da kwayar HCV biyu, Viekira Pak .
An amince da fasahar Technivie ranar 24 ga watan Yuli, 2015 ta Cibiyar Abinci da Drugura ta Amirka (FDA) don amfani da manya shekaru 18 ko fiye da tare da HCV genotype (GT4) ba tare da cirrhosis ba .
Technivie shi ne na farko, duk-baki, marasa lafiya na HCV na interferon ga marasa lafiya GT4 kamuwa da cutar HCV na kullum, yawancin mutane sunyi la'akari da wuya a bi da su.
An bayar da rahoton cewa Technivie yana da magani na 100% na baya-bayan nan da ba a hana su ba (marasa lafiya a cikin kullun) marasa lafiya a cikin gwajin II na gwagwarmaya da aka gudanar daga Agusta 12, 2012 zuwa Nuwamba 19, 2013.
Yankewa
Allunan guda biyu (Ombitasvir 12.5mg, 75mg paritaprevir, 50mg ritonavir) ana sha kullum tare da cin abinci ba tare da buƙatar babban abu ko mai amfani da caloric ba. Allunan na Technivie sune ruwan hoda, oblong da mai hotunan fim, tare da "AV1" wanda aka sanya a gefen daya.
Bayyana shawarwarin
An tsara takardun fasaha a cikin mako guda 12 tare da ribavirin (wani magani da ake amfani da su don hana RNA synthesis). Ƙwararren shawarar da ribavirin ya dogara akan nauyi, kamar haka:
- Kasa da 165 lbs (75kg): 1000mg yau da kullum, raba da kuma gudanar sau biyu a kullum tare da abinci
- 165 lbs (75kg) da kuma a kan: 1250mg kowace rana, raba kuma ana gudanar sau biyu a kowace rana tare da abinci
Hanya na mako-mako na Technivie za a iya la'akari da lafiyar marasa lafiya wanda ba zai iya jure wa ribavirin ba.
Hanyoyin Kasuwanci
Hanyoyin da suka shafi halayen da suka haɗa da amfani da Technivie (wanda ke faruwa a akalla 7% na marasa lafiya) sune:
- Rashin jiki
- Wulo
- Jiɗa
- Insomnia
- Rash
Contraindicated Magunguna
Dole ne kuma kada a dauka wadannan magunguna yayin amfani da Technivie:
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Antipsychotics: Orap
- Antiretroviral magani: Sustiva
- Cholesterol-rage yawan kwayoyin kwayoyi: Altoprev, Mevacor, Zocor
- Maganin dysfunction Erectile: Revatio
- Abubuwa na Ergot (amfani da maganin ciwon kai): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
- Estinyl estradiol-dauke da contraceptives: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Lutera, Alesse , Seasonique, Aviane, Ortho Evra, Xulane, Lo Lovingrin Fe, Necon 1/35, Minista 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo / Ovral, Ovral, Elinest
- Magunguna masu maganin tarin fuka-fuka na Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Versed, Halcion
- St. John's Wort
Contraindications da tunani
Ba a ba da shawara ga magungunan marasa lafiya da rashin ciwo na rashin lafiya (Banda-Pugh score B) kuma an haramta su a cikin marasa lafiya da rashin ciwo na rashin lafiya (Cutar Child-Pugh C).
An haramta amfani da Technivie don yin amfani da marasa lafiya tare da sanannun hypersensitivity zuwa ritonavir (watau, wanda ya sami cututtukan Stevens-Johnson ko kuma ƙwayoyin cuta mai tsauri).
Duk da yake Technivie a kan kansa ba a hana sabawa don amfani a cikin ciki, haɗin Technivie da ribavirin ne kuma bazaiyi amfani dashi ba a cikin mata masu ciki ko maza wanda mata masu ciki suke ciki. Game da nonoyar nono, babu wani tasiri na ciwon tayi na ciwon tayi a cikin nazarin dabba; Ana ba da shawara ga masu sana'a na musamman don tattauna yiwuwar amfani da cutar da nono a yayin Technivie.
Source:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta amince da Technivie don magance cutar cutar hepatitis C mai yawan gaske 4." Silver Spring, Maryland; sanarwa da aka bayar ranar 24 ga Yuli, 2015.
Hézode, C. Asselah, T .; Reddy, R .; et al. "Ombitasvir da paritaprevir tare da ritonavir tare da ko ba tare da ribavirin ba a cikin marasa lafiya da marasa lafiya da marasa lafiya da kwayar cutar ta kwayar cuta ta ciwon hepatitis C (PEARL-I): gwagwarmaya, gwajin rubutu." Lancet. Yuni 20, 2015; 384 (9986): 2502-2509.