Menene mun san game da haɗin tsakanin lupus da lymphoma? To, mun san fiye da yadda muka yi shekaru 20 da suka gabata, amma amsar za ta iya kasancewa "bai isa ba," in ji wani labarin da Boddu da abokan aiki suka buga a cikin labaran a cikin watan Maris 2017 na "Case Reports in Rheumatology."
Lupus, ko Likus Erythematosus (Siki) na Systemic Lupus
Lupus , ko kuma lupus erythematosus (SLE) na kwayar cutar, wani cututtuka ne mai rikitarwa wanda zai iya samuwa tare da wasu nau'o'in alamu daban-daban kuma zai iya ƙunsar tsarin kwayoyin halitta a cikin jiki.
Duk wani mutum biyu da lupus zai iya samun alamun wariyar launin fata, amma a nan wasu sunaye ne:
- Abun haɗin gwiwa, haɓaka da kumburi
- Wuci da zazzaɓi
- Gudun fuska akan fuska a kan cheeks da gada na hanci, ya ce ya zama mai launin fata, tare da hanci kamar jiki da cheeks a matsayin fuka-fukin malamai. Rashin gaggawa zai iya zama lokacin farin ciki, yana iya zama tayi, ko zafi.
- Wasu matsalolin fata wadanda suke ganin sun kara tsanantawa tare da hasken rana
- Yatsun yatsun hannu da yatsun kafa suna neman su rasa wurare dabam dabam, suna juya fari ko blue a cikin sanyi ko lokacin lokutan damuwa-wannan ana kiran rayayyar Raynaud
- Cutar cututtuka daga kwayoyin halitta daban-daban; rashin ƙarfi na numfashi, zafi ciwo, idon bushe
- Ciwon kai, rikicewa, da asarar ƙwaƙwalwa
Lymphoma, Cancer of Blood Cells
Lymphoma ciwon ciwon daji ne na jini mai tsabta, musamman jinin jini da ake kira lymphocytes . Nau'o'in lymphoma guda biyu sune lymphoma Hodgkin da lymphoma ba Hodgkin , ko NHL. Lymphoma yana farawa ne a cikin ƙwayoyin lymph, amma kuma zai iya haɗawa da kwayoyin halitta daban daban, kuma yana iya tashi a cikin nau'ikan takalma daban daban da kuma sassan jiki, ba kawai ƙwayoyin lymph ba.
Kamar dai tare da lupus, bayyanar cututtuka na lymphoma sun bambanta kuma mutane daban-daban suna da bambancin lymphoma. Wani lokaci, alamar kawai ita ce kumburi na lymph mai kumbura:
- Kuskuren kumburi na ƙwayar lymph a cikin wuyanka, ƙuƙwalwa, ko ƙuƙumi
- Wuci da zazzaɓi
- Drenching dare Sats
- Rashin ci abinci, rashin asarar nauyin da ba a sani ba - kamar yadda kashi 10 ko fiye na nauyin jikinka
- Itchy fata
- Ciki ko ƙwaƙwalwar kirji, ciwon ciki ko cikakken ciki, rashes, da kuma fata fata
Menene Wadannan Yanayi Biyu Keyi A Kullum?
Da kyau, wani lokaci alamun bayyanar zata iya farfado, daya. Kuma dukkanin cututtukan biyu sun haɗa da tsarin rigakafi: Lymphocytes su ne maɓallan maɓalli a cikin tsarin rigakafi, kuma tsarin na rigakafi shine abin da ke cikin SLE. Lymphocytes ma matsala ne a lymphoma.
Amma akwai kuma wannan: yawan karatun sun gano cewa mutanen da ke da SLE suna da ilimin lymphoma mafi girma idan aka kwatanta da jama'a. Ɗaya daga cikin ra'ayoyin da yawa shine, a cikin tsarin da ba shi da kyau (kamar yadda yake a wani wanda ke tare da SLE), yin amfani da farfadowa na immunosuppressive don magance lupus zai iya haifar da ƙara yawan lymphoma a SLE. Duk da haka, an yi nazari da yawa a kan wannan batu, tare da sababbin binciken, kuma wannan ba ya zama cikakken labarin ba.
Boddu da abokan aiki kwanan nan sun tara wasu daga cikin nazarin littattafai na likita don ƙarin bayani game da mutanen da ke da SLE wanda ke bunkasa lymphoma. Hanyoyin haɗari ga ci gaban lymphoma a cikin mutane tare da SLE ba cikakke ba ne. Mutane masu fama da cutar SLE da suka fi ƙarfin hali ko kuma sun kamu da kwayar cutar lymphoma, kuma wasu hadarin sun kasance sun danganta da yin amfani da cyclophosphamide da kuma ɗaukar hotuna mai zurfi zuwa steroids.
Kodayake a wasu lokuta akwai ƙananan binciken da za a zana-kuma sau da yawa yawan mutanen da ke tare da SLE da lymphoma su ne ƙananan a cikin waɗannan nazarin-Boddu kuma masu bincike sunyi amfani da abin da zasu iya samu don gina wani dandalin farawa domin ƙarin nazari. Wasu matakai da yawa daga nazari tare da marasa lafiyar SLE waɗanda suka fara karatun lymphoma.
Mutanen da ke da SLE da suka ci gaba da lymphoma:
- Mafi yawa mata ne
- Yawancin shekaru yana yawanci tsakanin 57 da 61
- A matsakaici, suna da SLE na tsawon shekaru 18 kafin lymphoma
- Rashin lafiyar Lymphoma a cikin mutane tare da SLE ya kasance mafi girma a cikin dukan kabilanci
- Kwayoyin cututtuka, binciken da jarrabawar jarrabawar lymphoma na farko-sama sun yi kama da abin da aka gani a SLE.
- Kumburi na kumburi na Lymph, wani lokacin alamar ilimin lymphoma ne kawai, yana da mahimmanci a cikin mutane tare da SLE, yana faruwa a kusan kashi 67.
Lymphomas da ke bunkasa a cikin mutane tare da SLE:
- Mafi yawan nau'in NHL a cikin mutanen da ke tare da SLE ya yada babban lymphoma na B-cell (DLBCL), wanda shine ma'anar NHL mafi yawan jama'a.
- Ƙididdigar DLBCL a waɗanda ke tare da SLE sun kasance sau da yawa kasancewa a cikin wani nau'in da ke ɗauke da ƙari-ƙari-cibiyar B-cell-like DLBCLs.
- NHL a SLE, kamar yadda yake tare da NHL a yawancin jama'a, yawanci sukan samo asali ne a cikin ƙwayoyin lymph, duk da haka lymphomas da suka fara waje da ƙwayoyin lymph suna yiwuwa a cikin yawan jama'a da wadanda suke tare da SLE.
Mutanen da ke da SLE suna kula da su da glucocorticoids, kadai ko hade tare da wasu kwayoyin cutar immunosuppressive ko kwayoyin cytotoxic ciki har da methotrexate, cyclophosphamide, da azathioprine don magance kwayoyin cutar ko bayyanar cututtukan da ba su amsa maganin da aka fara amfani dasu ba. Yawancin bincike sunyi ƙoƙarin ƙayyade idan magunguna na immunosuppressive sun kara yawan kwayar lymphoma a cikin mutane tare da SLE, amma sakamakon saurin binciken daya ya saba da na gaba.
Akwai hanyoyi da dama game da dalilin da yasa mutane da SLE na iya zama mafi hatsari ga ciwon daji a general, da kuma lymphoma musamman:
- Daya daga cikin waɗannan ka'idodin ya shafi ciwon kumburi. DLBCL da ke samo asali daga lymphocytes mai aiki shi ne mafi yawan ƙananan NHL da ke faruwa a SLE, saboda haka ra'ayin shine cewa ƙin ƙonewa zai iya ƙara yawan kwayar cutar lymphoma a cikin cututtuka irin su SLE.
- Wani ka'ida kamar irin wannan amma yana da ƙari game da tushen kwayoyin halitta. Dalilin shi ne cewa haɗin kai na SLE yana dauke da tsarin kwayoyin cuta don haifar da lymphocytes, kwayoyin lymphoma, don raba da kuma karuwa.
- Har ila yau wata ka'ida ta ƙunshi cutar Epstein-Bar, ko EBV. Wannan shine kwayar cutar daya da ke haifar da mononucleosis, ko kuma guda ɗaya, da ƙuƙwalwa. Ma'anar ita ce watakila wata cuta ta EBV da ke ci gaba, wanda ke ci gaba da tayar da tsarin rigakafi a cikin hanyoyi masu dacewa, yana cikin hanya na kowa don cutar ga SLE da B-cell lymphomas.
SLE, Lymphoma, da sauran Magunguna
Akwai kamuwa da haɗari ga Hodgkin da lymphoma ba Hodgkin a cikin mutane tare da SLE. Bisa ga bayanan da aka wallafa a shekara ta 2015, akwai ƙungiya tsakanin SLE da malignancy, ba kawai nuna NHL, lymphoma Hodgkin, cutar sankarar bargo, da wasu cututtuka ba tare da jini ba, amma har da laryngeal, huhu, hanta, vaginal / vulvar, da maganin karoid - kuma akwai yiwuwar ƙananan hadarin ganyayyun fata. Ciwon daji, ciwon huhu da ciwon daji da ciwon daji, da kuma ciwon daji na endometrial suna da alama su yi waƙa da SLE fiye da abin da za a yi tsammani ga yawan jama'a.
Mutanen da ke fama da ciwon Sjögren , yanayin da ya dace da mutanen da ke da SLE, suna fama da haɗarin lymphoma, don haka akwai wani abu mai mahimmanci ga cutar SLE da aka haɗu da malignancy da musamman lymphoma.
Duk da yake wasu nau'o'in immunosuppressive suna da lafiya ga mutanen da ke da SLE bisa ga binciken da yawa, wanda ke cikin litattafan wallafe-wallafe-wanda na ainihin lymphoma CNS (PCNSL) wani nau'i ne na NHL wanda ke faruwa a cikin tsarin kulawa na tsakiya ba tare da shaidar of lymphoma sauran wurare a cikin jiki. Kusan dukkan lokuta na PCSNL da aka ruwaito a cikin mutanen da ke tare da SLE suna hade da jami'in immunosuppressive, da kuma mycophenolate musamman.
> Sources:
> Boddu P, Mohammed AS, Annem C, Sequeira W. SLE da lymphoma ba na Hodgkin: jerin sassan da kuma nazarin wallafe-wallafe. Ra'ayin Rheumatol. 2017: 1658473.
> Cao L, Tong H, Xu G, et al. Rikicin Lupus na Gida da Rashin Malignancy: Meta-Analysis. Mai tsara M, ed. KUMA KUMA. 2015; 10 (4): e0122964.