Shin yana da nasaba da lymphoma?
An haifi Paul Langerhans a Berlin, Jamus, ranar 25 ga Yuli, 1847, dan likitan Jamus. Kashe don nazarin likita kamar mahaifinsa, yaro ya yi muhimmiyar gano yayin da yake da digiri. Sakamakonsa shi ne abin da aka sani da kwayoyin epidermal Langerhans, wanda shine maɓalli mai mahimmanci a yanayin da ake kira Langerhans cell histiocytosis.
Binciken Langerhans Dendritic Sel
Langerhans ya shiga cikin gasar bude gasar da Jami'ar Berlin ta shirya. Wani masanin ilimin kimiyya mai suna Julius Cohnheim ya riga ya ƙaddamar da hanyar yin amfani da hanzari na yin amfani da zinare na zinariya da ƙanshin haske.
Yin amfani da fasahar chloride na zinariya a 1868, Langerhans ya gani kuma ya bayyana wani abu a jikin fata wanda ba kamar sauran kwayoyin fata ba - ya bayyana shi a matsayin dendritic saboda yana da rassan kamar itace; amma kuma ya ce shi ba alamar ba ne. A wasu kalmomi, bai ƙunshi melanin pigment ba wanda yake a cikin wasu kwayoyin da ake kira melanocytes, wanda kuma aka haɗuwa, kuma su ne kwayoyin daga abin da melanoma ke tasowa.
A wannan lokaci, ya kaddamar da tantanin halitta wanda ba shi da alade shi ne wani mai karɓa don sigina ta fata zuwa tsarin mai juyayi. Bayan fiye da karni na baya, masana kimiyya za su koyi cewa sassan jiki na Langerhans suna da muhimmancin ayyuka a cikin tsarin da ba a rigakafi ba .
A 1973, Dokta Inga Silberberg ta gano cewa kwayoyin epidermal Langerhans sun wakilci "mafi yawan halayen tsarin jiki na tsarin rigakafi." A yau, ana ganin kwayoyin Langerhans ne a cikin iyali na dendritic sel, kuma su ne mafi ƙarancin nazari.
Kwayoyin Langerhans da aka gano a cikin fata suna zaton suyi aiki da kwayoyin halittar antigen.
Antigens sune '' tags '' '' masu amfani da kwayoyin halitta '' cewa tsarin na rigakafi na iya ganewa. Kwayoyin Halitta (APCs) sune kwayoyin da suke kwarewa wajen kama antigens, sarrafa su, da kuma nuna su a hanya ta musamman don a iya sanar da wasu kwayoyin da ba a iya ba da izini zuwa gaban antigen na waje. Tare da taimakon APCs, kwayoyin jinin jini na lymphocyte suna iya ganewa da amsawa ga ƙananan microbes da sauran masu haɗari.
Halaye na Langerhans Cell Histiocytosis (LCH)
Langerhans cell histiocytosis, ko LCH, aka fi son zuwa wani tsohuwar magana, "histiocytosis X," amma dukansu sunaye sun bayyana a cikin littattafai na likita. LCH shine ainihin rukuni na cututtuka wanda ke da karuwar yawancin kwayoyin Langerhans. Zai iya faruwa a kowane zamani, ko da yake yana da wuya a gani a cikin manya. Ko da yake LCH ya san kusan kimanin karni, masana kimiyya ba su fahimci dukkanin bayanai game da abin da ya haifar da shi ba.
LCH yana da alaƙa da juna ko "maƙalar" ƙananan wuraren ɓataccen ɓangaren ƙwayoyin da ke cikin ɓangaren da ke nuna cewa, lokacin da aka gano kwayoyin halitta, ya nuna cewa kashi ya maye gurbinsu ta tarihi tare da nuclei mai siffar bean.
Tarihin jini, kamar macrophages ko Kwayoyin dendritic, suna da kwayoyin halitta wanda ke halakar da wasu abubuwa waje don kokarin kare jikin daga kamuwa da cuta.
Wadannan masana tarihi, tare da lymphocytes, macrophages, da eosinophils, zasu iya kaiwa kusan dukkanin kwayoyin halitta, musamman ma fata, ƙwayoyin lymph, huhu, thymus, hanta, yalwa, yalwar kasusuwan, ko kuma tsarin kulawa na tsakiya.
Menene LCH Ya Yi da Lymphoma?
Wasu masana sunyi la'akari da cewa LCH na iya zama ci gaba mai zurfi daga cikin kwayoyin Langerhans wanda ke bin chemotherapy ko radiotherapy don cutar Hodgkin. Wannan shi ne daya daga cikin ra'ayoyin da yawa.
Yawancin lokuta na tarihin tarin kwayar cutar ta Langerhans da ke hade da lymphoma mai tsanani an ruwaito su a baya. Duk da haka, lokuta da aka ruwaito, sun faru da lymphoma m, da kuma bin lymphoma.
LCH shine mafi yawan yara a cikin yara daga shekara zuwa uku, wanda zai iya jin tsoro, amma tuna cewa LCH ba shi da ƙari.
Kwayar cututtuka suna dogara ne akan shafukan yanar gizo na hannu kuma cutar tana iyakance ga tsarin kwayoyin daya-kawai kashi, misali, a cikin rabin rabin lokuta. Wani lokaci mamayewar kashi baya samar da alamar bayyanar cututtuka, amma wasu lokutan akwai ciwo a cikin wani yanki na kashi. An yi amfani da cututtukan fata a kimanin kashi 40 cikin 100 na lokuta, kuma mafi yawan fata na fata shine ƙuƙwalwa kamar ƙwaƙwalwar kamala kamar kamuwa da yisti.
LCH zai iya zama da wuya a gane asali, amma tuna cewa ziyara ta yau da kullum zuwa likitanka da kuma tattaunawa mai ma'ana yana kara yawan haɓaka idan akwai wani abu daga cikin talakawa.
> Sources:
> Diapedia. Littafin Rayuwa na Ciwon sukari. Bulus Langerhans.
> Jaitley S, Saraswathi T. Pathophysiology na Langerhans Cells. Journal of Oral and Maxillofacial Pathology: JOMFP . 2012; 16 (2): 239-244.
> Langerhans P. Uber Die Nerven Der Menschlichenhaut. Tarihin Tsibirin Tsarin Hoto 1868; 44: 325-37.
> Li X, Deng Q, Li YM. Wani Maganin Langerhans 'Cell Histiocytosis Bayan Kwayar Hodgkin. Masanan kwayoyin halitta da ilmin cututtuka. 2016; 5 (1): 27-30.
> Satter EK, High WA. Langerhans Cell Histiocytosis: Binciken Shawarar Yanzu na Kamfanin Tarihin Tarihi. Pediatr Dermatol . 2008 Mayu-Jun. 25 (3): 291-5.