Celiac cutar wani yanayi ne na kwayar halitta, wanda ke nufin cewa kana buƙatar samun kwayoyin "'yancin' don inganta shi kuma a gano shi tare da shi. HLA-DQ2 yana daya daga cikin manyan kwayoyin cututtukan Celiac guda biyu, kuma ya faru ne ya zama mafi yawan kwayoyin halitta da ke faruwa a cikin cutar celiac (HLA-DQ8 shine sauran ake kira "celiac gene").
Yawancin likitoci sun yi imanin cewa kana buƙatar akalla kofe ɗaya ko dai HLA-DQ2 ko HLA-DQ8 don bunkasa cutar celiac.
Celiac Genetics Basics
Genetics zai iya zama batun mawuyacin hali, kuma jinsin cutar na Celiac yana da rikicewa. Ga wani ɗan bayani mai sauƙi.
Kowa yana da HLA-DQ kwayoyin. A gaskiya, kowa da kowa yana karbi nau'i biyu na kwayoyin HLA-DQ - daya daga mahaifiyarsu kuma ɗaya daga mahaifinsu. Akwai nau'o'in HLA-DQ daban daban, ciki har da HLA-DQ2, HLA-DQ8 , HLA-DQ7 , HLA-DQ9 da HLA-DQ1 .
Hanyoyin HLA-DQ2 da HLA-DQ8 sun haifar da haɗari na ciwon cutar cutar celiac.
Tunda kowa da kowa ya gaji HLA-DQ guda biyu (daya daga iyaye ɗaya), Zai yiwu mutum ya sami kwafin HLA-DQ2 (sau da yawa an rubuta shi kamar HLA-DQ2 heterozygous), biyu kofe na HLA-DQ2 (HLA-DQ2 homozygous) , ko babu kwafin HLA-DQ2 (HLA-DQ2 korau).
Bugu da kari, akwai akalla uku daban-daban na HLA-DQ2. Ɗaya, wanda aka sani da HLA-DQ2.5, ya ba da babbar haɗari ga cutar celiac; kimanin kashi 13 cikin 100 na mazauna Caucasian na Amurka suna ɗaukar wannan nau'in.
Duk da haka, mutane tare da wasu sigogi na HLA-DQ2 suna cikin hadari ga cutar celiac.
Idan Ina da Gene, Menene Danadin Na?
Wannan ya dogara.
Mutanen da suke da nau'i biyu na HLA-DQ2 (ƙananan ƙananan yawan yawan jama'a) suna ɗaukar mafi girma haɗari ga cutar celiac. Bisa la'akari da kimantaccen haɗarin haɗari dangane da binciken da aka wallafa ta hanyar binciken MyCeliacID na gwaji, cutar cutar Celiac ta faru a cikin mutane tare da nau'i biyu na DQ2 a cikin kusan sau 31 na yawan jama'a.
Mutanen da suke da nau'i biyu na HLA-DQ2 suna da haɗari ga ƙwayar ƙwayar cuta na celiac (wanda ke faruwa a lokacin da cin abinci mai cin abinci maras amfani ya yi kama aiki don sarrafa yanayin), da kuma haɗin T-interopathy. -lell lymphoma , wani irin ciwon daji wanda ke hade da cutar celiac.
Mutanen da suke da guda daya kawai na HLA-DQ2 suna da misalin sau 10 na hadarin "al'ada" don cutar celiac, a cewar MyCeliacID. Wadanda suke ɗauke da HLA-DQ2 da HLA-DQ8, sauran cututtukan cututtukan celiac, suna da kimanin 14 saurin hadarin "al'ada".
Sauran Ayyukan Kira
Ba duk wanda ke dauke da HLA-DQ2 yana tasowa cutar cutar Celiac - mahaifa yana cikin fiye da kashi 30 cikin dari na yawan jama'ar Amurka (musamman wadanda ke da Arewacin Turai), amma kimanin kashi 1 cikin 100 na jama'ar Amirka suna da cutar ta Celiac.
Masu bincike sunyi imanin cewa akwai wasu kwayoyin halitta da ke cikin ƙayyade idan mutumin da ke iya ɗaukar nau'in yanayin ya haifar da yanayin, amma basu riga ya gano dukkanin kwayoyin da suke ciki ba.
Sources:
Al-Toma A. et al. Tsarin Dan Adam Tsarin Halitta-DQ2 Homozygosity da Ci gaban Celiac Cigac da Enteropathy- T-Cell Associated Lymphoma. Clinical Gastroenterology da Hepatology. 2006 Mar; 4 (3): 315-9.
MyCeliacID Risk Stratification Table. Samun dama ga Maris 20, 2012.
Ploski R. et al. A HLA-DQ (alpha 1 * 0501, beta 1 * 0201) - haɗakarwa a cikin cututtukan Celiac: yiwuwar tasiri na DQB1 * 0201. Dabba Antigens. 1993 Afr, 41 (4): 173-7.
Vader W. et al. Hanyoyin HLA-DQ2 sun haifar da cututtuka a cikin cutar celiac suna da alaka da girman da yawancin sassan T cell. Ayyukan Cibiyar Kimiyya ta {asa. 2003 Oktoba 14; 100 (21): 12390-12395.