Harshen HLA-DQ7 ba a la'akari da daya daga cikin kwayoyin da za su iya haifar da ku ga cutar celiac . Amma akwai wasu shaidun cewa yana iya taka rawar a cikin yanayin, kuma mai yiwuwa a cikin wadanda basu iya ganewa ba .
Celiac cutar wani yanayi ne na ainihi, wanda ke nufin samun buƙatar "dama" don inganta shi. Masu bincike sun gano cewa jinsunan HLA-DQ suna da alama suna taka muhimmiyar rawa a cikin kwayar cututtuka-lalacewar halayen halayen da ke cikin cutar celiac.
HLA-DQ Genes da Celiac Cutar
Yi haƙuri tare da ni: wannan yana da rikitarwa da rikicewa.
Kowane mutum na da gado biyu na HLA-DQ daga iyayensu-ku sami ɗaya daga mahaifiyarku kuma ɗaya daga uban ku.
Akwai nau'o'i daban-daban na kwayoyin HLA-DQ, ciki har da HLA-DQ7, HLA-DQ2 , HLA-DQ8 , HLA-DQ9 da HLA-DQ1 . Kuna iya samun jinsin HLA-DQ daban-daban (mafi yawan al'amuran na al'ada), ko kashi biyu daga kashi daya na HLA-DQ na musamman (labarin da ba a taɓa gani ba).
Daga dukkanin nau'ukan daban-daban na HLA-DQ, akwai wasu da ake kira " cututtukan cututtukan Celiac :" HLA-DQ2 da kuma HLA-DQ8 na ƙasa. Yawancin mutanen da suka bunkasa cutar celiac suna da HLA-DQ2, yayin da ƙananan ƙarami suna da HLA-DQ8. Wadannan kwayoyin biyu suna dauke da asusun kimanin 96% na kowa da kowa da aka gano tare da cutar celiac.
Ta yaya HLA-DQ7 ke shiga cikin
Akwai mutanen da ba su ɗauke HLA-DQ2 ko HLA-DQ8 kuma suna ci gaba da cutar celiac.
Akalla binciken daya ya gano cewa rabin rabin wadannan mutane (a wasu kalmomi, game da kashi 2 cikin dari na duk mutanen da cutar ta Celiac) zahiri suna dauke da HLA-DQ7.
Wannan yana nuna HLA-DQ7 na iya zama wata halitta wanda zai iya sanya wasu mutane zuwa yanayin.
Duk da haka, ba a tallafa wannan ra'ayi a cikin wasu nazarin ba, kuma ana bukatar karin bincike don gano ko HLA-DQ7-wanda yake kama da HLA-DQ8-hakika zai iya haifar da cutar celiac, koda kuwa ba ku da ɗaya daga cikin manyan kwayoyin cutar kwayar celiac. A wannan lokaci, mafi yawan likitoci ba su la'akari da HLA-DQ7 don zama cututtukan cututtukan Celiac.
Haka ma HLA-DQ7 yana taka muhimmiyar rawa a cikin rashin lafiyar kullun celiac, yanayin da ake ganin ya bambanta daga cutar celiac (ko da shike cututtuka na kamuwa da guba sunyi kusan kamuwa da cutar cututtukan Celiac ).
Dr. Kenneth Fine, wanda ya haɓaka dabarun gwaji da aka yi amfani da shi a Enterolab (sabis na kai tsaye ga abokin ciniki), ya tattara bayanai na HLA-DQ akan yawan marasa lafiya na Enterolab. Ya kammala, bisa ga bincikensa wanda ba a buga shi ba, cewa HLA-DQ7 yana tsammanin za ku yi hankali. Duk da haka, magani na al'ada kullum yana raba wannan binciken saboda ba a buga shi ba kuma yana da shi.
Babu shakka akwai wasu kwayoyin da suka shafi ci gaba da cutar celiac, amma masu binciken basu riga sun gano su duka ba. Binciken bincike a hankali shine kawai farawa, kuma masana kimiyya basu yanke shawarar ko yanayin da yake da karfi ba.
Sources:
Sacchetti L. et al. Nuna bambanci tsakanin Celiac da sauran cututtuka na Gastrointestinal a cikin yara ta hanyar Rapid Human Lymphocyte Abiginal Typing. Mahimmin Kimiyya. Aug. 1998, Vol. 44, No. 8, p. 1755-1757.
Jami'ar Maryland Cibiyar ta Celiac Research sheet sheet. Celiac cututtuka Tambayoyi da yawa.