Binciken Bincike na Bincike Wannan Yakin da cutar Cutar Parkinson Daga Farawa
Magunguna da ake kira dopamine agonists kamar Requip (ropinirole) da Mirapex (pramipexole) ana amfani dasu don magance cututtuka na cutar Parkinson , musamman a farkon matakan.
Magungunan ƙwararrun magungunan ƙwayar magungunan ƙwayar yawancin sun saba da su kamar yadda ya kamata a kara tsawon lokacin da yake ɗaukar kafin mutumin ya fara (ko ƙara) yawan kashi na levodopa .
Levodopa shi ne magani mafi mahimmanci ga Parkinson, amma tasirinsa yana rage yawan wanda yake kan magani.
Bugu da ƙari da kasancewa marar daraja ga levodopa a magance alamun motsa jiki , masu tsauraran kwayoyin kwayoyin halitta ba suyi kome ba don rage yawan cutar.
Wadannan rushewar sun haifar da masu bincike don samar da sabon agonist dopamine, wanda ake kira D-512, wanda ba kawai yana bayyana mafi girma ga sauran masu tsauraran kwayoyin kwayoyin halitta ba dangane da kula da alamun motsa jiki amma zai iya kare kwayoyin suturar da ke ciki, wanda zai iya sanya damuwa akan cutar mutum feat).
Yana da mahimmanci a fahimci cewa D-512 yana cikin farkon matakan bincike. A gaskiya ma, ana nazarin shi ne kawai a cikin dabbobi. Duk da haka, yana da kyau mataki na farko don gano magani cewa fadace-fadacen cutar Parkinson daga farkon.
Bayani na D-512
Cututtukan Parkinson ya haddasa asarar kwayoyin tausayi na kwayoyin halitta a cikin yankin kwakwalwa da ake kira lambar daji.
Tunda dopamine ne ƙwayar kwakwalwa (wanda ake kira neurotransmitter) wanda ake buƙata don jiki ya motsa, motar (motsi) ya kasance daga wannan asara.
Duk da yake akwai alamun alamun motsa jiki da ke da alaƙa da cutar Parkinson, wasu nau'i hudu ne:
- Tsayawa raguwa
- Bradykinesia (ƙarfin da ya rage don motsawa)
- Rigidity
- Cutar rashin zaman lafiya
A matsayin madonist dopamine, D-512 yana ɗaure ga masu karɓar mahafan dopamine, ko shafukan yanar gizo, a kwakwalwa. Ta hanyar motsawa wadannan masu karɓa, D-512 yana amfani da kwayar kwakwalwa na kwakwalwar kwakwalwa (don haka kwakwalwa yana zaton yana da dopamine idan ba shi da gaske).
D-512 ya bambanta da sauran magunguna, duk da haka, saboda yana da dangantaka mafi girma ga masu karɓa na dopamine. Wannan yana nufin cewa zai iya ɗaure mafi sauƙi kuma mafi ƙarfin, wanda ya sa ya wuce tsawon lokaci.
Bugu da ƙari, yana da dangantaka mafi girma ga masu karɓa na dopamine, ana ganin D-512 don kare kodoyin da ke samar da kwayar halitta na dopamin wanda ke rayuwa, mai yiwuwa ta hanyar rage karfin mahaifa (wani abu mai mahimmanci ga "me yasa" bayan cututtukan Parkinson). Ta hanyar rage jita-jitaccen oxidative, D-512 za ayi la'akari da dukiyar mallakar antioxidant.
A wasu kalmomi, masu bincike sun yi imanin cewa d-512 zai iya zama magungunan cututtukan cututtuka ga cutar ta Parkinson saboda yana iya rage gudu.
Kimiyya Bayan D-512: Nazarin Dabbobi
A cikin binciken daya a cikin jaridar Birtaniya na Pharmacology, kwakwalwar ƙudaje sun kasance sunadarai da 6-hydroxydopamine (dopamine neurotoxin don maganin cutar Parkinson a cikin mutane). Daga nan, an ba da berayen ko D-512 ko Requip (ropinirole), kuma an kwatanta sakamakon.
Sakamako
Sakamakon binciken ya nuna mafi girman kwakwalwa da kuma matakan jini na D-512 fiye da ropinirole.
Bugu da ƙari, yayin da D-512 da ropinirole sun karu da ƙananan motsa jiki (a cikin berayen) zuwa irin wannan digiri daidai bayan allurar, tsawon lokacin da aka kunna motsa jiki ya fi tsawon D-512 fiye da ropinirole.
Mafi mahimmanci, maganganun da kwayoyin cutar ropinirole na kwayoyin cutar Parkinson ne kawai ya kai kimanin sa'o'i biyu, yayin da kwayar cutar ta D-512 ta dakatar da akalla sa'o'i hudu.
Hanyoyin da ke ciki: Dyskinesia
D-512 an lura da shi don haifar da dyskinesia, amma ga irin wannan matsala kamar yadda Requip (ropinirole), a cikin berayen. Dyskinesia tana nufin ƙungiyoyi masu banƙyama kamar writhing ko twitching da suke daga cikin mutum iko.
Yana da muhimmanci a lura da cewa yayin da dyskinesia ya zama sakamako na kowa na levodopa, yana faruwa a kimanin kashi 50 na mutanen dake fama da cutar Parkinson a shekaru biyar, basu da yawa a cikin mutanen da ke shan kwayar cutar.
A gaskiya ma, bincike ya nuna cewa dyskinesias, lokacin da mutum yake daukar kwayar cutar kwayoyin kadai, yana faruwa a kimanin kashi 5 zuwa 7 cikin mutanen da Parkinson ya dashi - kuma idan dyskinesias ke faruwa, suna da karfi a cikin tsanani kuma suna faruwa a baya.
Layin Ƙasa
Dukkanin, dyskinesias ba babbar matsala ce ga mutane masu shan kwayar cutar kadai ba (ba tare da levodopa) ba, don haka akwai yiwuwar ingantaccen sakamako mai amfani na shan D-512, idan aka kwatanta da sauran agonists na dopamine kamar Requip (ropinirole) .
Ka tuna, wannan bincike ne na dabba, saboda haka ya yi da wuri don yin wani mahimmanci. Lamarin ƙasa a nan shine cewa D-512 yana bukatar fassarawa cikin amfani da mutum.
Magunguna da masu aiki da kwayar cutar da kwayoyin cutar a cikin marasa lafiya
Bugu da ƙari ga zalunta da alamun motsa jiki a farkon yanayin cutar Parkinson, hujjojin kimiyya sun nuna cewa kwayoyin cutar dopamine sun amfana da alamun rashin motsa jiki, musamman matsalolin yanayi kamar damuwa, damuwa, da / ko rashin tausayi.
Maganin yaduwar cutar zai iya inganta wasu matsaloli masu zaman kansu kamar aikin jima'i ko sutura, da kuma wasu matsalolin matsalar barci a cikin cututtukan Parkinson kamar nakasar ciwo ko ƙarancin barci.
Wannan yana da alamar alkawari, kamar yadda masana ke mayar da hankali sosai a kan rashin alamun motsa jiki, kamar yadda sukan fara a baya fiye da alamun motsa jiki kuma suna iya zama masu haɗari.
Wancan ya ce, ba daidai ba ne cewa D-512 zai kasance mafi girma ga wadanda suka dace da kwayoyin dopamine irin su Requip (ropinirole) ko Mirapex (pramipexole) a sauƙaƙe wadannan alamun alamun ba.
Kalma Daga
A cikin nazarin dabba da aka ambata, yawan amfanin D-512 a kan Requip (ropinirole) shi ne cewa yana da tsawo kuma ya fi kyau a sakamakonsa.
Duk da haka, ana buƙatar ƙarin nazarin don ganewa idan wani fili kamar D-512 ya fi kyau fiye da halin da ake ciki a yanzu don maganin mutane da Parkinson.
Baya ga alamun motsa jiki da kuma sakamako masu illa, wasu abubuwa dole ne a yi la'akari da irin rayuwar mutum, lokacin da aka dakatar da farawa na levodopa, kuma D-512 yana da kyau na gyaran cutar (zai iya kare rayukan kwayoyin halittar kwayoyin halitta wanda ke har yanzu rayuwa).
> Sources:
> Batla A, Stamelou M, Mencacci N, Schapira AH, Bhatia KP. Ropinirole monotherapy ya haifar da mummunan cututtuka na dyskinesias a cikin kwayar cutar Parkinson. Yanayin Masa . 2013 Jul; 28 (8): 1159-60.
> Lindenbach D, Das B, Conti MM, Maadows SM, Dutta AK, Bishop C. D-512, wani labari mai maganin D2 / 3 mai cin zarafin Dama / 3, ya nuna inganci mai karfi na Parkinsonian fiye da ropinirole a ratsan kwayoyin Parkinson. Br J Pharmacol. 2017 Sep 174 (18): 3058-71.
> Mahalar W et al. Riga-yaduwa a cikin farkon kwayar cutar Parkinson: watau makonni 33 na gwajin gwagwarmaya. Ma'anar ilimin halitta. 2011 Aug 23; 77 (8): 759-66.
> Cibiyar Nazarin Michael J. Fox don Cibiyar Nazarin Parkinson. D-512: Mawallafi, D1 / D3 mai mahimmanci na maganin maganin cututtuka na Parkinson.
> Schaeffer E, Berg D. Dopaminergic hanyoyin kwantar da hankali don rashin alamun motsa jiki a cutar rashin lafiyar Parkinson. CNS Drugs . 2017 Jul; 31 (7): 551-70.