Maganganu na farawa Levodopa Tun da farko Vs Daga baya a Cutar Parkinson
Dopamine ne mai kwakwalwa wanda ya ɓoye daga jijiyar tara, wani karamin yanki a cikin kwakwalwa watau kwakwalwa wanda ya bushe a cikin cutar ta Parkinson . Kamar yadda matakan kwayoyin halitta a cikin kwakwalwa suka fara fadawa, alamun cutar Parkinson ya bayyana. Idan an maye gurbin dopamine, yawancin alamun sun inganta.
Daya zaiyi tunanin cewa, dole ne a ba dopamine a wuri-wuri.
Akwai wasu zaɓuɓɓuka, ko da yake. Bugu da ƙari, da aka ba dopamine kai tsaye (wata miyagun ƙwayoyi da ake kira carbidopa-levodopa), cututtukan kwayoyin Parkinson na marasa lafiya na iya amfani da su daga magungunan da ake kira dopon agonists. Wadannan kwayoyi ne wadanda ba dopamine ba amma suna da irin wannan sakamako akan tsarin mai juyayi. Wasu likitoci sunyi jita-jita cewa dole ne a yi amfani da kwayar cutar dopamine a baya a cikin cutar cuta kuma cewa tsofaffi marasa lafiya da akalla matsanancin nakasa ya kamata su karbi levodopa.
Magana game da Levodopa na farko Yi Amfani da cutar Cutar Parkinson
Levodopa shine magani mafi mahimmanci wanda za'a bi da alamun bayyanar Parkinson. Wannan ya ce, ba lallai ba ne ba tare da tasiri ba.
Ɗaya daga cikin tsoron tsoron amfani da levodopa shi ne cewa zai iya haifar da motsi mai yawa da ake kira dyskinesia . Mutane da ke fama da dyskinesia suna da motsi wanda ba shi da iko. Duk da yake yana da wuya, duk da haka, yawanci tare da dyskinesia sun fi son shi zuwa parkinsonism, kuma nazarin ya nuna cewa dyskinesia ba kyakkyawan tasiri akan rayuwar rayuwa ba.
Wasu masu bincike sun bayar da shawarar cewa dopamine na iya hanzarta saurin yanayin cutar yayin da yake nuna alamar bayyanar cututtuka. Ƙarin binciken bai tallafa wannan ra'ayi ba, duk da haka.
Kwayar cututtuka na iya ci gaba yayin da yake kan dopamine, ma'ana akwai lokuta na ranar da raguwa, rigidity, da raunin jinkiri ba su da kyau sosai fiye da sauran.
A gefe guda kuma, ba shi da tabbacin yadda waɗannan haɓaka suke tasiri tasiri na rayuwa. Bugu da ƙari kuma, mutane a kan wasu magungunan kamar magungunan kwayar cutar dopamine na iya samun haɓaka.
Wasu maganganu don tallafawa yin amfani da levodopa da farko sun ce zai inganta yanayin rayuwa a farkon wannan cuta, wanda ba a bai wa muhimmancin abin da ya dace ba. Levodopa kuma mai yawa ne mai tsada fiye da damun kwayoyi.
Kamfanonin ƙwayar ƙwayoyi ba su ƙara inganta amfani da levodopa ba saboda akwai nau'o'i masu yawa. A wasu kalmomi, akwai matsalolin kudi don kamfanonin kamfanonin magani don inganta amfani da wasu, magunguna masu tsada fiye da farkon cutar ta Parkinson, maimakon dogara ga tsohuwar levodopa, da gaske, kuma wannan zai iya rinjayar zaɓin masu likita.
Magana game da Levodopa na farko Amfani da cutar Cutar Parkinson
Mutane da yawa za su yi jayayya game da tasiri mai kyau na levodopa, kuma duk marasa lafiya na Parkinson zasu iya bukatar wannan magani. Akwai wasu jayayya masu tasiri don farawa daga baya a cikin hanyar cutar, ko da yake.
Magunguna suna buƙatar zama masu tsunduma a duk lokacin ci gaba da cutar. A wasu kalmomi, wanda ke fama da cututtukan Parkinson wanda ya fara a levodopa zai bukaci magani don a kara ƙaruwa yayin da cutar ta ba da damuwa.
Gaba ɗaya, iyawar dopamine za ta ci gaba bayan shekaru uku. Lokacin da yawancin levodopa ba su da ikon sarrafa bayyanar cututtuka, menene kuma akwai don juya zuwa? Ba tare da ƙarin maganin magani ba, tiyata mai yiwuwa ne kawai tunani. Shin ba ya fi kyau a ajiye "babban bindigogi" ba daga baya, lokacin da bayyanar cututtuka sun fi tsanani?
Bugu da ƙari, sakamakon illa na levodopa da aka tattauna, akwai ƙarin matsalolin da suka shafi rikice-rikice, ciki har da ƙaddamar da aiki na zuciya, rashin tausayi, da kuma karfin ikon motsa jiki. Gaskiya ne, duk da haka, wasu magunguna kamar kwayoyin dopamine suna da illa mai lalacewa, irin su kumburi, mummunar lalacewa da cututtukan ƙwayar cuta, irin su cigaba da caca.
A takaice, me yasa za ku yi amfani da "babban bindiga" da wuri, musamman idan masu bincike na baya (ko da sun kasance sun sabawa) sun nuna cewa zai iya sa cutar ta fi muni? Musamman ma lokacin da zaka iya amfani da magani mai magungunan da zai iya jinkirta tsarin cuta, ban da taimakawa tare da bayyanar cututtuka?
Shin Akwai Wasu Zaɓuɓɓuka Magunguna don Cututtuka na Parkinson?
Wani zabin zai kasance don fara magani irin su mai hana motsawa na monoamine oxidase. Misali shi ne rasagiline, wanda zai zama mai taimako sosai lokacin farawa da wuri. Wasu nazari sun nuna cewa rasagiline na iya jinkirta lalacewar cutar ta jiki ba tare da rikici da bayyanar cututtuka ba, waɗannan binciken sunyi jayayya sosai. Wannan ya bambanta da dopamine, inda wasu binciken farko suka nuna cutar ta kara tsanantawa da miyagun ƙwayoyi.
Rikicin Kasafi:
Yaya za a iya sulhunta wadannan ra'ayoyin biyu? Daga qarshe, babu wani tsarin magani wanda ya dace da kowa. Mutane suna da bambanci da kuma buƙatar magungunan da ake tsara su. Wata hanya mai yiwuwa za ta fara da magani kamar lagodine, sannan kuma ƙaramin kashi na levodopa. Yayin da cutar ta ci gaba, za'a iya kara kwayon kwayar cutar dopamine, sannan kuma wani babban kashi na levodopa. Karshe, duk da haka, mafi kyau mafi kusantarwa zai bambanta bisa ga bukatun marasa lafiya da kuma bukatun likita game da magunguna daban-daban.
Sources:
Marras C, Lang A, Krahn M, Tomlinson G, Naglie G; Cibiyar Nazarin Parkinson. Kyakkyawan rayuwa a farkon cutar kwayar cutar: tasiri na dyskinesias da mota motsi. Yanayin Masa. 2004 Jan, 19 (1): 22-8.
Parkkinen L, O'Sullivan SS, Kuoppamäki M, Collins C, Kallis C, Holton JL, Williams DR, Revesz T, Lees AJ. Shin levodopa ta hanzarta aiwatar da tsarin maganin cututtuka a kwakwalwar cutar ta Parkinson? Ma'anar ilimin halitta. 2011 Oktoba 11; 77 (15): 1420-6.
Sanya A, Kayan A A, van Laar T, Bloem BR. Yin magani na farkon cutar Parkinson: Levodopa sake gyara. Yi Neurol. 2011 Jun; 11 (3): 145-52.