Cholestyramine shine maganin miyagun ƙwayoyin cholesterol wanda ke da magungunan maganin bile acid. Nazarin ya nuna cewa cholestyramine ya fi saukin rage LDL cholesterol ta kimanin 15%. Cholestyramine ba ya bayyana ya tasiri wasu sifofin labaran ku ba amma yana iya kara matakan triglyceride a wasu lokuta.
An nuna cewa Cholestyramine ya jinkirta ci gaban ci gaban atherosclerosis a cikin wasu nazarin.
Duk da haka, ba'a nuna shi don hana mutuwa ko rashin lafiya saboda cutar cututtukan zuciya ba.
Cholestyramine an riga an amince da ita don amfani da Abinci da Drug Administration a watan Agustan shekarar 1973 ƙarƙashin sunan mai suna Questran. Tun da amincewar farko, an samo shi a karkashin sunayen kasuwancin Prevalite, Locholest, da sauransu.
Yaya Yada Ayyukan Cholestyramine?
Cholestyramine yana ɗaure zuwa biye acid cikin ƙananan hanji, yana hana halayen su. Ana samun albarkatun Bile daga cholesterol kuma ana buƙatar taimakawa tare da ƙwayoyin cuta masu cinye a cikin abincinka. Yayin da cholestyramine ke ɗaure zuwa biyan acid, za su zama raguwa kuma ba za a sake su ba. Don samun karin bile acid, za a cire cholesterol daga jinin jini kuma ya koma cikin bile acid. Wannan aikin yana rage ƙwayar cholesterol.
Ta Yaya Zaku Yi Zaɓin Cholestyramine?
Ya kamata ku dauki cholestyramine kamar yadda mai bada sabis na kiwon lafiya ya umurce ku.
Cholestyramine yana samuwa a cikin nau'i mai ƙura, an saka shi cikin ƙananan buƙatun guda guda ko a cikin akwati mafi girma.
Mai bada sabis na kiwon lafiya zai iya fara maka a ƙananan ƙwayoyi kuma ƙara yawan kashi naka bisa ga amsawarka ga magani da kuma sakamako masu illa. Farawa na farko da aka fara amfani da shi shi ne safiyar ko ɗaya (4 grams cholestyramine) sau ɗaya ko sau biyu a rana.
Wannan na iya ƙarawa har zuwa shida allurai a rana. Ya kamata a hade da kashi biyu da ruwa guda biyu, ruwan 'ya'yan itace (tare da ko ba tare da ɓangaren litattafan almara), applesauce, miyaccen mai, ko sauran abin sha ba kafin cinyewa. Ya kamata ku yi amfani da duk abinda ke ciki na abincin da ke dauke da cholestyramine don samun cikakken kashi na magani. Za a dauki Cholestyramine tare da abinci.
Wane ne ya kamata ba dauka ba?
Saboda abubuwan da aka gyara, akwai wasu lokutta da ba za a dauki cholestyramine ba. Wadannan zasu hada da:
- Mutanen da suka riga sun sami rashin lafiyar maganin cholestyramine ko wani daga cikin kayan da ya dace bazai dauki cholestyramine ba.
- Duk wanda aka bincikar da shi tare da ɓoyewar biliary, inda ba a ɓoye albarkatun bile cikin ƙananan hanji.
Yanayin da ake Bukatar Kulawa
Idan kana daukar cholestyramine, mai bada sabis na kiwon lafiya na iya buƙatar saka idanu da kai a hankali idan kana da wasu yanayin kiwon lafiya wanda za a iya kara matsawa ta hanyar shan magani. Idan kana da wasu daga cikin sharuɗɗan da ke ƙasa, mai bada sabis na kiwon lafiya zai iya yanke shawara don farawa a kan cholestyramine amma zai buƙaci saka idanu akanka don sanin ko karbi cholestyramine zai kasance da cutarwa a gare ku.
Waɗannan yanayin kiwon lafiya sun haɗa da:
- Babban matakan triglyceride. An nuna Cholestyramine don kara matakan triglyceride a cikin binciken. Idan kana da manyan tiglycerides, mai bada sabis na kiwon lafiya zai duba matakanka don tabbatar da cewa basu zama maɗaukaki ba.
- Samun ci gaba da maƙarƙashiya. Cholestyramine na iya kara damuwa da wannan yanayin idan ka sha wahala daga maƙarƙashiya.
- Hawan ciki. An kirkiro Cholestyramine a matsayin Ciki C C. Ko da yake ba a yi nazari da yawa akan nazarin tasiri da aminci na cholestyramine a cikin mata masu ciki. Tun da wannan miyagun ƙwayoyi zai iya rage yawancin bitamin, wadansu sassa na bitamin tinatal bazai iya tasiri ba yayin shan cholestyramine. Mai ba da sabis na kiwon lafiya zai yanke shawarar ko yakamata ka dauki wannan magani.
Hanyoyin Gaba
Riba shi ne mafi yawan abin da aka lura a yayin da ake daukar cholestyramine. Wannan yakan tafi tare da ci gaba da kulawa. Mai bada sabis na kiwon lafiya zai iya yanke shawara don rage ƙwayar ka ko kuma ba ka magani don magance maƙarƙashiyarka idan sakamakon da ya shafi ya zama mawuyacin hali. Sauran halayen haɗuwar sun hada da:
- Ruwan jini
- Flatulence
- Jiɗa
- Belching
- Vomiting
- Abun ciki da rashin jin daɗin ciki
Wasu rahotanni masu illa sun ruwaito saboda rashin amfani da cholestyramine. Ƙara yawan samuwa na zub da jini za a iya lura da shi a tsawon lokaci saboda ragewan Vitamin K. Bugu da ƙari, canza a cikin hanta enzymes da yashwa na enamel na ɗan haɗi na iya faruwa saboda shan shayarwar samfurin ko rike samfur naka.
Sadar da Magunguna
Wadannan kwayoyi zasu iya hulɗa tare da cholestyramine ta rage yawan adadin magani da aka sanya cikin jini. Manufacturer ya bada shawarar kada ya dauki wasu magunguna ko kariya akalla sa'a daya kafin ko 4 zuwa 6 hours bayan shan cholestyramine. Idan ana buƙatar ka ɗauki ɗaya daga cikin kwayoyi ko kariyan da aka lissafa a ƙasa, mai bada sabis na kiwon lafiya na iya buƙatar daidaita ƙimarka ko lokacin da kake karɓar shi, saka idanu akanka don sakamako masu illa, ko katse amfani da shi duka tare:
- Hanyoyin hawan kuɗi
- Lanoxin (digoxin)
- Kwayoyin maganin haihuwa
- Cholesterol-ragewan magunguna (ciki har da fibrates, ezetimibe, statins)
- Ma'aikatan anti-inflammatory masu ba da ka'ida ba (NSAIDs)
- Corticosteroids
- Diuretics (ciki har da hydrochlorothiazide, spironolactone, furosemide)
- Warwarwar (warfarin)
- Bitamin mai-mai narkewa (bitamin A, D, E, da K)
- Magungunan magani, kamar Dilantin (phenytoin) da phenobarbital
Akwai wasu magunguna da dama da zasu iya hulɗa tare da cholestyramine, wanda aka jera a sama. Sabili da haka, ya kamata ka sanar da ma'aikacin lafiyar ka da duk wani magungunan da aka tsara da kuma kan-da-counter, da samfurori na jikin da kake ɗauka. Wannan zai taimaka wa mai baka sabis na kiwon lafiya don gano duk wani tasiri mai kyau tsakanin cholestyramine da sauran magunguna.
Layin Ƙasa
Cholestyramine yana daya daga cikin magungunan ƙwayoyin cholesterol na farko da aka rage a Amurka. Ana amfani da ita don rage ƙwayar karamar LDL amma ba a nuna kai tsaye ba don samar da mutuwar ko rikitarwa daga cututtukan zuciya kamar na wasu magungunan ƙwayoyin cutar a cikin kasuwa. Ya kamata ka sanar da lafiyarka na lafiyar idan kana fuskantar matsaloli tare da shan cholestyramine tun lokacin da ƙwayar da ke da ƙwayar zai iya samun dandano mai gishiri wanda zai yi wuya a haɗiye wasu mutane. Saboda matsalar cholestyramine kawai zai shafi tasirin ku na LDL cholesterol, mai ba da sabis na kiwon lafiya zai iya yanke shawara don ƙara wasu hanyoyin kwantar da hankali - irin su statin ko fibrate - ga tsarin gurɓin ku.
Sources:
Tsayawa (Cholestyramine). Upsher-Smith Laboratories. Maple Grove, MN. Revised 4/2015.
Dipiro JT, Talbert RL. Pharmacotherapy: A Approach Pathophysiological, 9th ed 2014.
Micromedex 2.0. Ƙididdiga na Lafiya ta Gaskiya, Inc. Greenwood Village, CO. Akwai a http://www.micromedexsolutions.com.