Abubuwan Bincike na Bincike
Amitriptyline wani shahararren antidepressant ne wanda ke samuwa ne kawai a cikin nau'in halitta a Amurka. An sayar da ita a karkashin sunan mai suna Elavil.
An amit Amitriptyline a matsayin mai antidepressant tricyclic. Shekaru da dama, wasu likitoci sunyi la'akari da shi a matsayin maganin fibromyalgia da ciwo mai tsanani ( ME / CFS ). Duk da haka, wannan ya zo game da ƙarin daga aikace-aikacen gwagwarmaya da kuskure fiye da nazarin asibiti.
A cikin 'yan shekarun nan, musamman idan zuwan maganin fibromyalgia ya amince da FDA, amfani da amitriptyline ga waɗannan rashin lafiya ya ki. Amitriptyline har yanzu, duk da haka, wani lokacin ana amfani dashi a matsayin magani na maganin maganin fibromyalgia, kuma yawancin likitoci sun rubuta shi don waɗannan yanayi.
Yadda Yake aiki
Amitriptyline da sauran kwayoyi masu tricyclic suna tsammanin za su kara yawan adadin dinar da ke tattare da serotonin da kuma norepinephrine cewa kwakwalwarka zata iya amfani. Suna yin hakan ta hanyar rage jinkirin tsarin da ake kira "reuptake," wanda shine lokacin da kwayoyin musamman ke amfani da masu amfani da neurotransmitters don haka za'a iya amfani da su a wasu wurare.
Sauran antidepressants, waɗanda ake kira reuptake inhibitors, amfani da daban-daban hanyoyin don cimma irin wannan sakamako.
Serotonin da norepinephrine an yarda su zama dysregulated a cikin fibromyalgia da ME / CFS.
Haka kuma Duba:
Fibromyalgia
Wani nazarin amitriptyline na 2012 game da fibromyalgia yana da wannan akan maganin miyagun ƙwayoyi a fibromyalgia:
Amitriptyline ya kasance magani na farko don jin ciwon neuropathic shekaru masu yawa. Gaskiyar cewa babu wata shaida mai ban sha'awa da ke nuna goyon baya ga sakamako mai tasiri ba shi da dadi, amma dole ya kasance daidai da shekarun da suka samu nasara a cikin marasa lafiya da yawa da ciwon neuropathic ko fibromyalgia. (Moore, et al, a kasa.)
Binciken ya ci gaba da cewa maida hankali ga tasirinta yana damuwa ne saboda binciken da aka yi a kwanan nan ya nuna kawai 'yan tsirarun mutanen da suke gwadawa zasu sami taimako mai zafi.
Wani bita a wannan shekarar, wanda ya hada da magungunan maganin duloxetine da magunguna, ya ce:
Ƙananan marasa lafiya suna fama da gwagwarmayar gwaji tare da babu wani sakamako mara kyau. Duk da haka, yawancin marasa lafiyar marasa lafiya sunyi saurin farfadowa saboda farfadowa masu illa ko kwarewa kawai ƙananan alamun bayyanar cututtuka, wanda ba ya ƙetare mummunar tasiri. (Hauser, Wolfe et al, a kasa.)
Binciken 2011 (Clemons, et al, a kasa) ya kammala cewa ba za a dauki amitriptyline a matsayin misali na zinari na fibromyalgia ba saboda rashin iyakokin binciken da aka gudanar.
Duk da haka, har a shekara ta 2011, nazarin magungunan miyagun ƙwayoyi ga fibromyalgia (Smith, et al, a kasa) ya bayyana cewa amitriptyline ya kasance kamar kamfanonin FDA-sun yarda da su - Lyrica (pregabalin), Cymbalta (duloxetine), da Savella (milnacipran) lokacin da ya zo da zafi da gajiya.
Wasu likitoci sun fi son amitriptyline don wasu dalilai:
- Yawan tarihin amfani, da kuma
- Kudinta mai yawa idan aka kwatanta da maganin FB-approved fibromyalgia.
Alal misali, samar da wata amitriptyline na wata daya zai iya kudin tsakanin kimanin $ 15 da $ 65, dangane da sashi. A halin yanzu, samar da watanni daya na Cymbalta (duloxetine), Lyrica (pregabalin), ko Savella (milnacipran) farawa a kimanin $ 125 kuma zasu iya kimanin dala $ 180. (Wannan na iya canzawa kamar yadda duloxetine ya zo akan kasuwar.)
Mawuyacin Ciwo Ciki
Amitriptyline yana da tarihin amfani dashi ga ME / CFS, kuma duk da rashin kulawa na asibiti da kuma sakamakon abubuwan da ake kyautatawa a duniya. An yi bincike kadan kadan.
Binciken bincike na 2012, yayi la'akari da amitriptyline ga ME / CFS kuma ya gano cewa ita kadai ne daga cikin magungunan antidepressants da aka jarraba su wanda ya hana yaduwar suturar mast-cell na cytokines masu ƙwayar cuta , waɗanda aka yi imanin suna taka rawar a ME / CFS.
Yankewa
Ga manya, samfurin amitriptyline na iya samuwa daga 40 MG har zuwa 150 MG kowace rana. Ana rarraba shi zuwa ƙananan allurai.
Zai iya ɗauka har tsawon wata guda don ku lura da canje-canje saboda wannan magani.
Tabbatar ku bi umarnin likitan ku don shan wannan magani. Idan kana so ka daina ɗauka, kada ka tsaya kawai. Ka tambayi likitanka game da hanyar da ta dace don warware wannan magani.
Hanyoyin Gaba
Kamar yadda yake tare da dukkanin antidepressants, yana ɗaukan gargadi game da ƙarin ƙaddarar tunanin ƙaddanci ko ƙoƙari a cikin mutane a karkashin shekaru 24.
Amitriptyline yana da jerin lokuta masu tasiri. Abubuwan da ke cikin lalacewa sun hada da:
- Unsteadiness,
- Nightmares,
- Nuna ko zubar,
- Difficulty urinating,
- Riba,
- Sugar wucewa,
- Canje-canje a nauyi ko ci,
- Canje-canje a cikin jima'i ko kuma iya yin jima'i,
- Pain, ƙona ko tingling a hannun ko ƙafa.
Idan kana da wasu daga cikin cututtuka masu tsanani, to ya kamata ka kira likitanka nan da nan:
- Magana mai laushi, wahalar magana,
- Fainting,
- Rashin rauni ko ƙididdigar wani ɓangare,
- Crishing chest pain,
- Ƙwararrun zuciya,
- Mai tsananin raguwa ko amya,
- Kusawar fuska da harshe,
- Yellow fata ko idanu,
- Muscle spasms a cikin jaw, wuyansa da baya,
- Ƙararrawar girgiza,
- Ƙusar jini ko ƙetare,
- Rijiyoyi,
- Majalisa.
Saboda wannan maganin yana kara yawan samari na serotonin, ya kamata ku guje wa sauran kwayoyi wanda ya kara yawan ciwon sukari da kuma koyi da alamar bayyanar cututtuka mai cutarwa: Serotonin Syndrome.
Kamar yadda yake tare da kowace miyagun ƙwayoyi, yana da mahimmanci a gare ku da likitanku don ƙalubalancin haɗari ga amfanin ku kuma yanke shawarar abin da wajibi ne ya dace da ku.
Sources:
Clemons A, et al. Journal of Clinical psychopharmacology. 2011 Jun, 31 (3): 385-7. Amitriptyline da prochlorperazine inhib proinflammatory matsakanci saki daga sassan jikin mutum: yiwuwar dacewa ga ciwo mai wuya.
Hauser W, Petzke F, et al. Rheumatology (Oxford.) 2011 Mar; 50 (3): 532-43. Daidaitaccen inganci da yarda da amitriptyline, duloxetine da milnacipran a cikin ciwon fibromyalgia: nazari na yau da kullum tare da meta-bincike.
Hauser w, Wolfe F, et al. Magunguna na CNS. 2012 Apr 1; 26 (4): 297-307. Matsayin magungunan antidepressants a cikin gudanar da ciwo na fibromyalgia: nazari na yau da kullum da kuma kwaskwarima.
Moore RA, et al. Cochrane database na dubawa tsarin. 2012 Dec 12; 12: CD008242. Amitriptyline na ciwon neuropathic da fibromyalgia a cikin manya.
Okea, R. likitan iyali na Amirka. 2010 Oktoba 15; 82 (8): 901-904. Milnacipran (Savella) don fibromyalgia.
Smith B, et al. Drug Class Reviews. 2011 Apr. Drug Class Review: Drugs for Fibromyalgia: Final Final Report.
Cibiyar Abinci da Drugta ta Amirka. Amitriptyline Safety Alert. Samun shiga Satumba 2014.