Myeloproliferative neoplasms (MPN), da ake kira da myeloproliferative disorders, sune rukuni na cuta da ke nuna yawan ƙwayar jini ko jini (jini mai launin jini, sel jini, da / ko platelets). Kodayake kuna iya haɗawa da kalmar neoplasm tare da ciwon daji, ba haka yake ba.
Neoplasm an bayyana a matsayin ciwo mai maganganta na nama wanda zai haifar da maye gurbi kuma za a iya classified shi azaman bala'in (wanda ba zai iya yiwuwa) ba, mai tsauraran zuciya, ko mummunan (m).
A ganewar asali, yawancin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta ba su da kyau amma a tsawon lokaci zasu iya zama mummunan cututtuka (cututtukan). Wannan hadarin ci gaba da ciwon daji tare da waɗannan ƙwayoyin cutar yana nuna muhimmancin bin bin hankali tare da likitan ku.
Kaddamar da ƙananan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta sun canza sauƙi a cikin 'yan shekarun nan amma za mu sake nazarin jumloli a nan.
Classic Myeloproliferative Neoplasms
A "classic" myeloproliferative neoplasms sun hada da:
- Magunguna na polycythemia (PV): PV daga sakamakon maye gurbin kwayar halitta wanda zai haifar da karar jini. Wani lokuta ana daukar nauyin ƙwayar jini da kuma platelet. Wannan ƙwanƙasa a cikin ƙididdigar jini yana ƙaruwa da haɗarin bunkasa jini. Idan an gano ku tare da PV, kuna da ƙananan damar bunkasa myelofibrosis ko ciwon daji.
- Muhimmancin Thrombocythemia (ET): Halittar kwayoyin halitta a ET tana haifar da wani ɓarna a cikin platelets. Ƙara yawan yawan talifin da ke cikin wurare dabam dabam yana ƙara haɗarin haɗarin yaduwar jini. Rashin haɗarin bunkasa ciwon daji lokacin da aka bincikar da TT yana da ƙananan. ET yana da mahimmanci a cikin MPNs kamar yadda yake da ganewar asali. Wannan yana nufin likitanku zai mallaki wasu dalilai na ƙididdigar platelet ( thrombocytosis ) ciki har da sauran MPNs.
- Myelofibrosis ta farko (PMF): An kira myelofibrosis na farko da ake kira mielofibrosis na agiopathic ko museloid agugenic metaplasia. Halittar halittar kwayar cutar a cikin PMF ta haifar da ƙananan (fibrosis) a cikin kasusuwa. Wannan maganin ya sa ya zama ƙalubalanci don ɓawon kasusuwa don yin sabon jini. Ya bambanta da PV, PMF kullum yana haifar da anemia (ƙananan jinin jini). Za'a iya ƙara yawan ƙwayar jinin jini da ƙididdigar platelet ko ƙãra.
- Magungunan cutar sankarar Myeloid na yau da kullum (CML) : Ana iya kira CML kwarojin cutar sankarar myelogenous. CML sakamakon daga maye gurbin da ake kira BCR / ABL1. Wannan maye gurbi yana haifar da overproduction na granulocytes, irin nau'in jini. Da farko, ba za ka iya samun alamun bayyanar cutar ba, kuma an gano CML a lokaci ɗaya tare da aikin lab na yau da kullum.
Maganin Miiloproliferative Neoplasms
Kwayoyin da ke tattare da kwayoyin halitta sune:
- Kwayar cutar sankarar rigakafi ta yara (JMML): An kira JMML karamin CML. Wannan mummunan cutar sankarar bargo ne wanda ke faruwa a jariri da yaro. Kullun kasusuwan ya fi ƙarfin jinin jini mai launin jini, musamman wanda ake kira monocyte (monocytosis). Yara da nau'o'in neurofibromatosis I da Noonan ciwon haɗari suna da haɗari mafi girma na bunkasa JMML fiye da yara ba tare da waɗannan yanayi ba.
- Kwanan nan Neutrophilic cutar sankarar bargo: Tsarin cutar sankarar neutrophilic na yau da kullum shine cututtuka mai wuya wanda ya haifar da kariyar neutrophils, irin nau'in jini. Wadannan kwayoyin zasu iya haifar da gabobin jikinka kuma suna haifar da fadada hanta da kuma yaduwa (hepatosplenomegaly).
- Kwanin cutar sankarar bargo / Ero-cycosinophilic (HES): Bikin cutar sankarar eosinophilic na yau da kullum da kuma hypereosinophilc mahaukaci suna wakiltar rukuni na cuta wanda ke nuna yawan adadin eosinophils (eosinophilia) wanda zai haifar da lalacewar gabobin daban daban. Wasu mutane na HES sunyi kama da magungunan myleoproliferative neoplasms (saboda haka sunan mai cutar da cutar sankarar jini eosinophilic).
- Kwayar Mast Cell: Tsarin jiki (ma'ana a jikin jikinsa) ƙwayar cuta ta mast ko mastocytosis wani inganci ne na sababbin nau'in jinsi na ƙwayoyin myeloproliferative neoplasms. Sakamakon cututtuka na kwayoyin mast daga sakamakon cikas daga cikin kwayoyin mast, wani nau'in jini na jini wanda yasa ya kai ga kututture na kasusuwa, gastrointestinal tract, fata, yaduwa da hanta. Wannan ya bambanta da mastocytosis cututtukan da kawai ke shafar fata. Kwayoyin mast sun saki histamine sakamakon sakamakon rashin lafiyar jiki a cikin abin da aka shafa.
Sources:
Roufosse F, Klion AD da Weller PF. Harkokin Hypereosinophilic: Harkokin Clinical, Pathophysiology, da kuma ganewar asali. A: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Samun shiga ranar 27 ga Yuni, 2016)
Teferri A. Mahimman bayanai game da ƙananan ƙwayoyin cuta na myeloproliferative. A: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Samun shiga ranar 26 ga Yuni, 2016.)
Van Eatton RA. Bayyanawa na asibiti da kuma ganewar asali na cutar cutar sankarar myeloid. A: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Samun shiga a kan Yuni 28, 2016.)