An Bayyana Mahimmanci na Farfesa don Mahimmancin Thrombocythemia
Muhimmancin Thrombocythemia (ET) yana daya daga cikin rukuni na jini wanda ake kira mopopododal neoplasms. Sauran nau'o'in ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta sun haɗa da myelofibrosis da kuma ƙwayoyin polycythemia .
Halittar kwayoyin halitta a cikin magungunan thrombocythemia da ke kaiwa zuwa babban nau'in platelet ƙira (thrombocytosis). Mutane da yawa ba tare da bayyanar cututtuka ba a lokacin ganewar asali kuma suna da yanayin rayuwa ta al'ada.
Rarraba sun haɗa da ciwon gurgun kafa (wanda zai haifar da bugun jini, ƙwayar zuciya, jini a cikin huhu, ko ɓangaren ƙwayar zuciya), ci gaba da myelofibrosis , ko kuma canji zuwa m cutar cutar sankarar myeloid (AML). Ɗaya daga cikin sababbin matsalolin da ake amfani da shi na thrombocythemia shine ci gaba da ciwon von Willebrand Disease , cutar ta jini.
Mafi yawan mutane za su buƙaci farfadowa a wani lokaci don hana rikitarwa. Duk da haka, yanayin rayuwa na al'ada ba abu bane.
Jiyya Zɓk
Idan an bincikar ku da mahimmancin maganganu na gaba tambaya ta gaba shine, "menene zaɓuɓɓukan maganin na?" Akwai hanyoyi da dama da likitanku zasu tattauna da ku. Maganar da likitanku ya ba da shawara yana iya dogara ne da dalilai masu yawa: alamun ku, shekarun ku, da kuma abubuwan da ake dasu na labarun. Yawancin mutane za su tafi shekaru da yawa ba tare da bukatar magani ba, wanda aka fara farawa idan kun ci gaba da gudan jini.
- Aspirin: Anyi amfani da aspirin yawancin asali ne don magance mutane da bayyanar cututtuka. Vasomotor bayyanar cututtuka sun hada da ciwon kai, damuwa, zafi ciwo, wanke hannaye da ƙafa, da kuma canji na gani. Ba a saba da maganin aspirin ba don amfani da wasu jiyya. An yi amfani da farfita aspirin mai girma kamar wani haɗari na jini yana ba da shawarar.
- Hydroxyurea: Magungunan kwayar cutar chemotherapy hydroxyurea rage haɗarin thrombosis a muhimman thromobcytosis ta rage karbar platelet. An fara amfani da hydroxyurea a kashi mai mahimmanci kuma yayi girma har sai adadin platinum yana kusa da al'ada (100,000 - 400,000 Kwayoyin ta microliter). An yi amfani da hydroxyurea ba tare da wani sakamako mai mahimmanci ba. Hanyoyi masu lalacewa sun haɗa da hyperpigmentation (darkening) na fata, gyaran ƙusa (yawanci tsararrun launi a karkashin ƙusa), ƙuƙwalwar fata, da kuma ulcers. Hydroxyurea kuma yana rage yawan ƙwayoyin jinin jini (musamman ƙididdigar neutrophil) da kuma hemoglobin wanda ke buƙatar kulawa ta kusa da ƙididdigar jini (CBC).
- Anagrelide: Anagrelide magani ne mai ma'ana wanda ya rage yawan ƙwayar platinet ta hanyar hana yin amfani da platelets a cikin kututture. Ana amfani da ita lokacin da hydroxyurea ba tasiri ba. Hakazalika da hydroxyurea, Anagrelide ya fara ne a ƙananan kashi kuma ya ƙãra har sai sakamako mai so. Hanyoyi masu lalacewa sun hada da ciwon kai, sanyaya (m zuciya), riƙewar ruwa, da kuma zawo. Wadannan illa masu illa sunyi maganganu tare da ci gaba da kulawa.
- Alpha interferon: Alpha interferon za a iya amfani da su don sarrafa countlet count a cikin muhimmanci thrombocythemia, polycythemia vera, da kuma primary myelofibrosis. Har ila yau, zai iya rage girman ƙwanƙara. An yi amfani da Alpha interferon subcutaneously (a karkashin fata) kowace rana. Har ila yau, Alpha interferon yana samuwa a cikin wani nau'i mai tsawo wanda ake kira intergyron wanda zai iya bawa sau ɗaya a mako. Tsarin Interferon yana yawanci adana ga mata masu ciki ko mutanen da ba su amsa maganin hydroxyurea ba.
- Plateletpheresis: Plateletpheresis wata hanya ce ta kawar da platelets daga wurare dabam-dabam. An cire jinin ta hanyar amfani da kwayar jini (IV) kuma an tattara ta a cikin na'ura wanda aka ware daga cikin wasu sassan jini (kwayoyin fararen fata, da jini mai jini, da kuma plasma). Jubar da jini, ƙananan plalets, ya koma jiki ta hanyar IV ko dai tare da bayani saline ko plasma. Plateletpheresis an tanadar wa mutanen da ke dauke da ƙwan zuma mai mahimmanci, ƙaddarar jini (a cikin huhu, kwakwalwa), ko zub da jini. Sakamakon sakamako na plaletpheresis na wucin gadi ne don haka wani magani zai bukaci a fara don karewa na tsawon kwanakin platelet.
Dukkanin maganin da aka ambata a sama ba su warkewa matukar muhimmanci ga thrombocythemia. Suna kawai rage yawan abincin plalet din yana rage yawan hadarin da zai haifar da jini ko kuma ya sami ciwon wuka na Wienbrand. A wannan lokacin, babu wani maganin curative don muhimmancin thrombocythemia. Abin farin ciki, duk da rashin ciwon maganin curative, mafi yawan mutanen da ke da mahimmancin thrombocythemia na iya zama rayayyen rayuwa.
Sources:
Teferri A. Gabatarwa da Kula da Mahimmancin Thrombocythemia. A: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Samun shiga ranar 15 ga Yuni, 2016)