OTC masu rarraba da ke dauke da rubutun phenylphrine ba su da kyau.
A shekara ta 2006, Shugaba Bush ya sanya hannu kan dokar yaki da cutar ta Methamphetamine ta Combat, wani gyare-gyare ga Dokar Patriot, a cikin doka. Anyi amfani da Dokar Cutar Gidajin Methamphetamine Tafiyar da wuya ga mutane su sami Sudafed da sauran alamu masu rarraba wanda ke dauke da pseudoephedrine ta hanyar motar da waɗannan samfurori a bayan bayanan kantin magani, yana buƙatar masu siyarwa don samar da ID na hoto, da kuma hana tallace-tallace zuwa 7.5 grams kowace abokin ciniki a wata.
Bugu da ƙari, jihohi da yawa sun sanya ƙananan haɗin kansu akan farashin pseudophedrine. Wadannan canje-canje sun kasance sun hana dakatar da wadannan kwayoyi don samar da kwayar cutar methamphetamine.
A sakamakon wannan canji, da yawa masu yin magungunan miyagun ƙwayoyi sun kori pseudophedrine don phenylephrine a cikin yawancin masu cin gashin gurasar maganganu. Amma a nan ne batun game da phenylephrine: Ba ya aiki da kyau. Idan ka taba saya kaya don ka ci hanci, mai yiwuwa ka samu kadan ko a'a. Musamman musamman, idan zai yiwu kuma ana buƙata don sauƙin gaggawa, saya Sudafed mai dadi (wanda ya ƙunshi pseudoephedrine) maimakon Sudafed PE (wanda ya ƙunshi phenylphrine). Bugu da ƙari, idan kuna buƙatar Sudafed, ya kamata ku yi alƙawari don ganin likitan ku na farko.
Menene Zamuyi da Phenylephrine?
Dukkanin pseudoephedrine da phenylephrine sune kwayoyi masu amfani da kwayoyi wadanda suke aiki a kan jin dadi ("yakin ko jirgin").
A ka'idar, wadannan kwayoyi zasu bushe ku wanda shine dalilin da ya sa aka sanya su a cikin tari daban-daban da kuma kayan sanyi a lokuta tare da maganin kawu da antihistamines. Bayanan kula, masu bincike sun nuna cewa kamar phenylephrine, maganin antihistamines ba su da kaɗan don nuna damuwa da sanyi.
Musamman, pseudoephedrine yana da ayyuka na alpha-da beta-adrenergic kai tsaye da kuma kai tsaye amma na asibiti yana samar da karin beta-adrenergic stimulation.
Ganin cewa, phenylephrine ne mai haɗari mai haɗari na alpha-adrenergic.
Bambanci mai mahimmanci tsakanin magunguna guda biyu yana da nasaba da ƙananan matakan rikice-rikice na metabolism na farko. Ganin cewa kashi 90 cikin dari na pseudoephedrine ya sa ta cikin gut a cikin kwakwalwar jiki, kawai kashi 38 na phenylephrine ya sa shi cikin jinin mu. A wasu kalmomi, za ka kawo karshen cin nasara fiye da fiye da jikin dan hankalin jikinka.
Binciken kan Phenylephrine
Don zama gaskiya, bincike akan tasiri na phenylphrine a sauya nauyin gizon nassi ya haɗa, kuma a duk wurin. Alal misali, misalin kwatanta kwatancin kwatancin gwargwadon gwargwadon ci gaba da gwargwadon hanzari na 10 da kwayar gizon wuri a cikin mahalarta bincike ya nuna cewa phenylephrine zai iya rage yawan jigilar iska, mai mahimmanci don ragewa, ta hanyar kashi 20 cikin 100. Duk da haka, wannan bincike ne aka tallafa wa wani kamfani na bukatun cinikayya.
An yi amfani da jarrabawa da kuma sauran nazarin kwatancen phenylephrine tare da placebo da cewa ba'a nuna bambanci tsakanin su biyu cewa mai yiwuwa phenylephrine baiyi kaɗan ba sai dai ya sauƙaƙe takardar dollar.
Daga bayanin kula, wasu masu bincike sun nuna cewa saboda karuwar jigilar fassarar farko da haɓakawa ta hanyar haɓakaccen kwayar cutar phenylephrine zai iya taimakawa wajen haɓaka ƙwayar hanci.
(Don Allah a tattauna dukkanin magunguna da maganin tare da likitan ku.) Amma wanene ya san? Abin da muka sani shi ne cewa a cikin kwayoyi masu guba wadannan kwayoyi masu amfani da kwayoyi sunyi tasiri da cututtuka ciki har da cutar hawan jini mai tsanani (hauhawar jini), ciwon jini na intracranial, ko kuma magungunan zuciya wanda ke haifar da maimaitawa ko ma sau biyu a kan sashi wani abu mai wuya.
Kalma Daga
Don Allah a tuna cewa ko da yake ba ka buƙatar takardar sayan sayan magungunan ƙwayoyi ba, suna da kwayoyi masu tasiri tare da tasiri masu tasiri. Ya kamata ku tambayi likitanku koyaushe kafin shawara kuyi amfani da kwayoyi. Bugu da ƙari kuma, idan kuna shan magungunan ƙwayoyin cuta don rashin lafiya, ya kamata ku yi rashin lafiya da likitanku ya kimanta.
Idan kai ko ƙaunatacciyar yana da mummunan hali na ƙuntataccen ƙuƙwalwar ƙwayar ƙwayar ƙwayar jiki, yi wa kansa ni'ima da kuma kawar da magungunan magunguna (OTC) da ke dauke da rubutun phenylephrine. Idan dole ne, kuma don amfani da gajeren lokaci kafin ka ga likitanka na farko, la'akari da shirye-shiryen da ke dauke da pseudoephedrine (wanda zai iya aiki mafi kyau fiye da phenylephrine) ko kuma mai lalacewa na hanci a cikin rubutun fure (rubutun gishiri).
Don Allah a tuna cewa ko da yake yana da mahimmanci a cikin gajereccen lokaci, yin amfani da tsautsayi na yau da kullum na iya haifar da haɗuwa na ƙananan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta , wata maɗari mai banƙyama wadda ta ƙare ƙananan ƙuntatawa na hanci. Bugu da ƙari, idan kwakwalwarka ko wasu alamar sanyi na ci gaba da kwanaki da yawa, dole ne ka yi alƙawari don ganin likitan likita, likita ko likitan likita wanda zai iya gane ko yanayinka ya fi kamuwa da cutar numfashi.
> Sources
> Benowitz NL. Babi na 132. Gidaran daji, Phenylephrine, da sauran masu ba da gaskiya. A: Olson KR. eds. Cigaba da Drug Overdose, 6th . New York, NY: McGraw-Hill; 2012.
> Mataki na farko mai suna "Lafiya da Tsaro na Phenylephrine Harshe: Binciken Tsaro da Meta-Analysis" na RC Hatton da masu marubuta da aka wallafa a The Annals of Pharmacotherapy a 2007.
> Mataki na farko da ake kira "Babbar phenylephrine: Sauyawa mai maye gurbin pseudoephedrine?" by L Hendeles da RC Hatton da aka buga a cikin Journal of Allergy and Clinical Immunology a shekara ta 2006.
> Mataki na farko da ake kira "Meta-Analysis of the Efficacy of a Single Matter of Phenylephrine 10 MG Idan aka kwatanta da Placebo a cikin Adults tare da Raccan Nasal Manda saboda Cold Cold" by C Kollar da co-marubuta da aka buga a Clinical Therapeutics a 2007.
> Westfall TC, Westfall DP. Babi na 12. Masu Jituwa da Ƙwararrun Masanan. A cikin: Brunton LL, Chabner BA, Knollmann BC. eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th . New York, NY: McGraw-Hill; 2011.