Tarihin ita ce sinadaran da aka samo shi kuma an fitar da shi daga kwayoyin mast wanda zai iya haifar da wasu bayyanar cututtuka dangane da ɓangaren jiki inda tarihin histamine ya faru:
- Hanci: hanci da sauri
- Idanu: damuwa, ruwa
- Al'umma: ciwon, scratchy
- Lullu: rudani , ƙwaƙwalwar kirji , rashin ƙarfi na numfashi , da kuma tari
Yaya Tarihin Tarihin Yayi
Tarihin ita ce mai jarida ta hanyar rigakafi ko, mafi sauƙi, manzo ne wanda ke taimakawa wajen mayar da martanin jikinka ga maƙwabcin waje.
Tarihin yana nuna hanyoyin kare lafiyar jikinka game da yadda za a amsa wani abu da ya fahimta a matsayin kasashen waje. A cikin fuka da kuma rashin lafiyar jiki, jikinka yana karuwa da wani abu da ba shi da cutarwa ba amma ya sa tsarinka na rigakafi ya amsa. Tarihin tarihin aikin haɗin sadarwa tsakanin sassa daban-daban na tsarin rigakafi.
A cikin asma, histamine na inganta ƙwararraɗi da kuma samar da ƙuduri.
Yaya Tarihin Yazo Daga?
An fitar da tarihin daga kwayoyin mast da kuma basophils yayin da kake nunawa ga allergens. Lokacin da aka sake fitar da histamine, farawar rashin lafiyar zata fara. Ana amfani da kwayoyi antihistamine a maganin rashin lafiyar cututtuka da aka lalata ta histamine. Wasu magunguna na anti-histamine sun hada da:
- Zyrtec
- Allegra
- Claritin
- Benadryl
Leukotriene Shirya Drugs
Wata magungunan kwayoyi da ke magance wasu sakamakon sakamakon histamine su ne masu gyara leukotriene.
Wadannan kwayoyi sun taimaka mahimmanci da kuma rage yawan ƙwayoyin gwagwarmaya da kuma kara da cewa rage karfin rubutu ko kumburi da kuma samar da eosinophils a matsayin ɓangare na pathophysiology na asma.
Wadannan magungunan sunyi haƙƙin maganin magunguna da kuma nazarin bincike da yawa da suka dace da wannan magani idan aka kwatanta da sauran jiyya na asma.
Yawancin takardun magani suna bayar da shawarar yin aikin gwajin lokaci, wanda ya riga ya zama ɓangare na shirin kula da asibiti. Bugu da ƙari, akwai wasu alaƙa da hulɗar da ke fama da yakin warfarin jini da kuma canje-canje na hali da aka lura a matasa. Yayinda ake ganin rashin tausayi da yawa a cikin matasa, ba a samu karuwa ba a cikin wadanda suka kamu da su.
Yawan nazarin da yawa sun nuna alamun sakamako na bronchodilatory da cigaba a cikin bayyanar cututtukan fuka. Sauran matakan mahimmanci sun lura da rage yawan yin amfani da masu ceto , da kuma rage yawan ƙwaƙwalwar fuka da kuma samfurori da ke buƙatar maganin ƙwayar maganin fuka-fuka kamar prednisone . Duk da haka, waɗannan kwayoyi ba su zama kamar tasiri kamar masu ciwon sukari ba don fuka. Yawan karatu daban-daban sun nuna alamar inganta aikin ƙwayar cuta a cikin ƙwayoyin steroid, ƙananan haɗari suna faruwa, kuma marasa lafiya suna samun ƙarin kwanakin marasa lafiya. A sakamakon haka, jagoran ƙasashe suna bada shawara ga masu steroid kamar yadda aka yi amfani da su na farko a yayin da kake buƙatar fiye da wanda yake mai ceto.
An san cewa sanyewar haɗari ga steroid din da aka yiwa ciki shine suboptimal, kuma yawancin karatu sun nuna karfin haɗin kai ga adadi na yau da kullum idan aka kwatanta da steroid a cikin yara da manya.
Iyaye suna damu da damuwa game da illa masu tasiri na steroids masu haushi kuma suna likitawa akai akai.
Matsayin da ya dace ga montelukast zai iya bayyana irin tasirin da ya dace akan tasirin fuka ga wadanda ke cikin GC a cikin wasu nazarin "real-world". Kodayake muhimmancin wannan batu a cikin aikin likita, an yi shi ne a cikin gwaje-gwaje na asibiti, nazarin da ke jagorantar maganin miyagun ƙwayoyi ta hanyar FDA, ta hanyar binciken masu gudanarwa suna ba da hankali akai-akai ga marasa lafiya da kuma cire marasa lafiya wadanda suka yarda da su (kamar yadda aka rubuta ta hanyar masu sa ido na lantarki wanda aka gina a cikin na'urorin haɓaka) yana da talauci.
Har ila yau, ya bayyana cewa masu kula da asibitoci na farko sun saba da maganin steroid. Sabili da haka, ko ta yaya masu amfani da cututtukan masu amfani da cututtuka masu amfani, masu amfani da su a cikin saitunan duniya suna iyakance ne ta rashin dacewar rubutun da kuma biyan.
Duk da yake ba a zabi mafiya zabi ba bisa ka'idodin tarin fuka na yanzu, masu gyara leukotriene su ne hanya mai dacewa a matsayin mai bada shawara na farko don marasa lafiya wanda bazai dauki ko kuma ba zai iya jurewa maganin steroid ba. Tabbatar da wannan tsari yana goyan bayan wani gwajin da ake kira "pragmatic" wanda aka gudanar a cikin marasa lafiya 306 da ke gudanar da ayyukan kulawa na farko, wanda aka nuna a matsayin wanda ya kasance daidai da steroid din da aka yiwa asiri.
> Sources
> Busse et al. Low-dose fluticasone propionate idan aka kwatanta da montelukast don kula da farko na asthma ci gaba: A gwaji na asibiti gwaji. J Allergy Clin Immunol 2001; 107: 461-8
> Zuciya ta Duniya, Lung, da Ciwon Blood. Rukunin Sakamakon Kwararri na 3 (EPR3): Sharuɗɗa don Bincike da Gudanarwa na Tsira
> Scaparotta A et al. Montelukast da ciwon gurgunta corticosteroids a cikin kula da yara likitancin m ciwon sukari. Multidiscip Respir Med. 2012; 7 (1): 13.