Prucalopride don ƙaddarar lokaci

Prucalopride wani magani ne wanda aka tsara don magance maƙarƙashiya na yau da kullum - matsalar lafiyar da ke faruwa a cikin wani lokaci mai tsawo da kuma matsala na wasu lokutta da dama, tare da sauran abubuwan da ke nuna damuwa kamar bayyanar jini, flatulence, har ma vomiting. Hanyoyin maganin gargajiya don ƙwarewa na yau da kullum ya ƙunshi yawancin abinci da kuma canje-canje na rayuwa da / ko laxatives.

Prucalopride a halin yanzu akwai kawai a Turai, ƙarƙashin sunan mai suna "Resolor" da Kanada a matsayin "Resotran". Hukumar Kula da Magunguna ta Turai (EMA) ta amince da yin amfani da prucalopride (Resolor) kawai don magance maƙarƙashiya na yau da kullum a cikin mata waɗanda basu da amsa ga amfani da laxatives . Ana gudanar da nazarin don samun amincewa ta hanyar EMA don amfani da prucalopride a cikin maza da ke shan wahala daga maƙarƙashiya.

Yaya Ayyukan Prucalopride Yayi?

Prucalopride an kwatanta shi ne agonist 5-HT4. Wannan yana nufin cewa yana kunna masu karɓa na 5-HT4 don serotonin neurotransmitter. Ana yin tunanin wannan haɓaka yana ƙara motility daga tsarin na hanji ta hanyar haɓaka peristalsis, ko kuma ƙwayoyin tsoka na hanji wanda zai iya fitowa daga cikin jikin, yana da sauƙi don wucewa kuma ya haifar da ƙungiyoyi masu yawa.

Prucalopride yana da magunguna daya kamar Zelnorm.

Duk da haka, an tsara prucalopride don yin wani aiki daban a jiki don rage yiwuwar rashin bayyanar cututtukan zuciya amma mai tsanani wanda ya sa Zelnorm ya fita daga kasuwa.

Yaya Yayi Amfani da Prucalopride a Yin Saurin Gwaji?

A cikin gwaje-gwaje na asibiti har zuwa yau, an nuna cewa prucalopride ya kasance mafi girma ga placebo a cikin wadannan yankuna:

• Ƙara yawan yawan motsa jiki na kwatsam da cikakke.
• Inganta fahimtar haƙuri game da ingancin rayuwa.
• Yawanci a fahimtar halayen cewa maƙarƙashiya ba shi da matsala.

Mene ne Hanyoyin Hanya na Prucalopride?

A cikin karatu har zuwa yau, an sami sakamako masu illa mai zuwa:

• Diarrhea
• Ciwon kai
• Jiɗa

Shin Prucalopide Taimaka IBS?

A cikin nazarin bincikensa na baya-bayan nan, Cibiyar Kwalejin Gastroenterology ta Amurka ta ƙarasa cewa bincike na goyon bayan tasirin prucalopride don maƙarƙashiya da kuma IBS-C. Masu bincike na ACG sun lura cewa prucolopride baya ɗaukar ƙwayar cutar Zelnorm mai tsanani.

Wanene ba za a ɗauki Prucalopide ba?

Wasu mutane suna fuskantar haɗarin haɗari don bunkasa halayen haɗari masu haɗari ko rikitarwa daga shan prucalopride. Wadannan sun hada da mutane:

• Sanarwar da aka sani ga miyagun ƙwayoyi ko wani nau'in hade
• Rashin ƙyama na ainihin da ake buƙatar dialysis
• Tsinkayar intestinal ko tsangwama
• Ginin ƙusa
• Yanayin ƙananan cututtuka na fili na hanji
• Mawuyacin cututtuka da cututtukan marasa lafiya marasa lafiya, musamman cututtuka ko ƙwaƙwalwar cututtukan zuciya.

_Sources:

_{Ford, A., et.al. " Cibiyar Kasuwancin Gastroenterology na Amirka na Gudanar da Harkokin Ciwon Buka da Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙasa " Jaridar American Journal of Gastroenterology 2014 109: S2-S26.}

_{Ford, A. & Suares, N. "Sakamakon laxatives da magungunan maganin maganin maganin maganin maganin ƙwayoyin maganin ƙwayoyin cuta a cikin ƙwararriyar ƙwarewa na idiopathic: nazari na yau da kullum da kuma kwaskwarima" Gut 2011 60: 209-218.}

_{Maneerattanaporn, M., Chang, L., & Chey, W. "Wuraren Samun Kwayoyin Pharmacology na Farko don Ƙarƙashin Ciwon Buka". Gastroenterology Clinics of North America 2011 40: 22-243.}

_{"Safiya yana farawa karo na III gwajin gwaji da prucalopride a cikin marasa lafiyar namiji da cike da maƙarƙashiya" Movetis NV Press Release 24 ga Satumba, 2010.}

_{"Resolor" Cibiyar Harkokin Kiwon Lafiyar Turai ta Amince da Maris 17, 2011.}

_{Quigley, E. "Prucalopride: aminci, inganci da kuma aikace-aikace na aikace-aikace Harkokin Turawa a Gastroenterology 2012 5: 23-30.}