Mepolizumab da Reslizumab na Eosinophilic Asthma
Asthma wata cuta ce ta yau da kullum da take shafi kashi 12 cikin dari na yawan jama'a kuma yana da mahimmanci a Amurka da wasu kasashen Westernized. Shahararra tana nuna halin da ake ciki na rudani, tari, rashin ƙarfi na numfashi da ƙwaƙwalwar kirji, tare da bayyanar cututtuka wanda ya fito ne daga m ko rikice-rikice zuwa tsanani da kuma barazanar rayuwa.
Mutane masu fama da ciwon sukari mai tsanani za su iya samun raguwa mai yawa a cikin ingancin rayuwa kuma zasu iya shawo kan matsalolin da ke haifar da buƙatar ƙwayoyin corticosteroid ta hanyar jihohi , tawon shakatawa, da kuma asibiti.
Akwai wasu magungunan asibiti daban-daban don kula da asma. Yawanci waɗannan sun hada da corticosteroids masu haushi , masu tayar da hankula, da leukotriene gyare-gyare, irin su Singulair . Mutane da ke fama da ciwon hauka mai tsanani suna buƙatar amfani da Xolair . Duk da waɗannan magungunan masu kula da magunguna, duk da haka, yawancin ƙwayoyin mahaukaci na ci gaba da samun matsalolin da ake buƙatar yin amfani da maganin cralicosteroid.
Xolair shi ne na farko da ake amfani da maganin ilimin likitanci na likita domin maganin asarar fuka mai tsanani. Yana da wani wanda yake da alaka da IgE . Wannan yana nufin cewa an sanya wani antibody a cikin dakin gwaje-gwaje da kafawa da cutar IgE-wani "maɓallin tayarwa" don rashin lafiyan halayen. Lokacin da asthmatic na da rashin ciwo, irin su doki ko ƙurar ƙura , kuma bayyanar cututtuka ba ta sarrafawa ta hanyar sababbin magunguna irin su corticosteroids, waɗanda za a iya amfani da Xolair don rage cututtukan fuka da kuma juyayi.
Nucala don Asthma
Yawan nau'o'in maganin ƙwayoyin ƙwayoyin maganin ƙwayoyin cuta suna samar da su domin magance nau'o'in fuka wanda bazai iya amsawa ga al'ada ko Xolair ba. An yarda da kwayoyi guda biyu a cikin marigayi 2015 da farkon 2016 don maganin asma mai tsanani wanda yake dauke da jini mai yawa ko sposum eosinophils.
Nucala (mepolizumab) na daya daga cikin wadanda ke dauke da kwayar cutar IL-5, da sinadarai da ke haifar da samarwa, ci gaba, da kuma kunnawa na eosinophils. Eosinophils ne kwayoyin jini masu rai wanda zai iya haifar da lalacewar nama, ƙumburi, da kuma ƙwayar tsoka a cikin huhu daga cikin mahaifa.
Nucala yayi aiki ta hanyar rikici da sakamakon IL-5, wanda hakan zai haifar da rage yawan adadin sputum da jini eosinophils. Binciken farko tare da mepolizumab ya kasa nuna duk amfanin wannan sakamako a yawancin mutanen da ke fama da asma. Duk da haka, mutanen da ke fama da ciwon sukari mai tsanani da kuma manyan matakan sputum ko zubin jini sun kasance sun fi dacewa da amfani da mepolizumab.
Musamman, mutanen da ke dauke da irin wannan asma sun iya rage yawan maganin ƙwayoyin maganin ƙwaƙwalwar maganin ƙwaƙwalwa don ɗaukar fuka-fuka, suna ci gaba da inganta tsarin kula da fuka (ƙananan cututtukan fuka-fuka,) kuma suna da ƙananan ƙwaƙwalwar fuka a cikin lokaci. Wasu binciken har ma sun nuna cewa akwai ci gaba a cikin aikin sutura yayin daukar Nucala.
An nuna Nucala don maganin mummunan cututtuka, fosinophilic fuka a cikin mutanen da ke da shekaru 12 da haihuwa wadanda ba su amsa maganin asibiti. Sakon yana daidai da kowa ga kowa, ba tare da shekaru, nauyi ko matakin eosinophil-wanda yake shi ne milligrams 100 da aka ba da su a matsayin asibiti a kowane mako hudu.
Sakamakon sakamako na Nucala sunyi kama da wadanda ke cikin injections, duk da cewa akwai damuwa ga anaphylaxis a matsayin tasiri tare da magungunan maganin halittu. Sakamakon anaphylaxis shine kashi daya cikin dari na inganci na Nucala, amma kashi biyu cikin 100 ga wadanda suke samun inboctions. Duk da yake Nucala ba shi da gargadi na fata don anaphylaxis, za'a iya kula da mutane masu karɓar kwayoyin Nucala na tsawon lokaci ta hanyar likita a cikin maganin anaphylaxis.
Cinqair don Asthma
Cinqair (reslizumab) yana aiki ne kamar yadda Nucala yake da shi-shi ma wani magungunta guda daya ne akan IL-5, amma dai kwayoyin halitta daban daban ne.
Cinqair ma yana kara rage adadin sputum da jini na eosinophils, inganta cututtukan fuka da kuma aiki na huhu, da kuma rage kwarewa a cikin kwayoyin cutar tare da babban sputum da eosinophils na jini. Cinqair yana da amfani sosai a cikin rukuni na fuka-fuka da ƙananan polyps tun lokacin da yawancin kwayoyin polyp sun fara kamuwa da IL-5.
An nuna Cinqair don maganin mummunan cututtuka na fosinophilic a cikin mutanen da shekarun 18 suka tsufa kuma ba su amsa maganin cutar fuka ba. Sashi yana da nauyin nauyin nauyin nauyin nauyin nauyin nau'i a kowane mako hudu. Sakamakon anaphylaxis a cikin mutane masu karbar Cinqair shine kashi 0.3 cikin dari kuma saboda haka suna da gargadi na fata wanda yayi kama da Xolair.
> Sources:
> Patterson MF, Borish L, Kennedy JL. Tsohuwar, Gabatarwa da Gabatarwa na Monoclonal Antibodies zuwa IL-5 da Asthma Eosinophilic: A Review. Journal of Asthma and Allergy. 2015; 8: 125-134.