Ƙarin madaurarwa, amma illa masu tasiri na iya ƙayyadewa
Migraines na ci gaba da kasancewa a cikin yanayin kwakwalwa-ko da tare da gabatar da samfurori, wanda magunguna ne da aka saba amfani dashi don halartar kai hare-haren ƙaura na matsananciyar tsanani.
Matsalar tare da masu cin nasara shine cewa ba kawai sukan yi aiki ga mutane ba - fiye da kashi 35 cikin dari, bisa ga bayanin kimiyya. Har ila yau, wasu mutane sukan guje su saboda matsalolin da ba su dace ba, kamar ƙwaƙwalwar kirji, ƙwaƙwalwa da tsoka na tsoka, da ƙuntatawa da kuma tingling sensations.
Saboda haka, akwai wata hanya madaidaiciya ga ɗaukar wajan gudun hijira? Zai iya zama daya a sararin sama kuma an kira shi lasmiditan. Kamar kowace miyagun ƙwayoyi, ko da yake, lasmiditan ma yana da wasu ƙasƙanci wanda har yanzu ana buƙatar a ƙayyade shi ta hanyar masu bincike.
Duk da haka, koyo game da wannan magungunan miyagun ƙwayar cutar ta migraine yana cikin mafi kyawun ka saboda yana iya fitowa a matsayin zaɓin mai yiwuwa donka a nan gaba. Bugu da ƙari, idan tasiri, lasmiditan zai iya samar da karin haske game da ilmin halitta a bayan hare-hare na migraine . Kuma, mafi mahimmanci, zai tallafa wa ka'idar ƙananan ƙananan ƙaura kamar yadda ya saba da ka'idar ƙwayar cuta ta asali.
Shin Lasmiditan Safe & Aminci?
Ya zuwa yanzu, akwai gwaji guda biyu na lasmiditan:
Nazarin Ɗaya
Bisa ga binciken da aka samu a cikin Lancet , watau mai amfani da wuri-mai gudanarwa a cikin Lancet, lasmiditan yana da tasiri ga zalunta ƙwayar cutar migraines mai tsanani. A cikin wannan binciken, mahalarta sun kasance bazata don karɓar kofi na wuribo ko kwayar jigilar kwayoyin halitta (50mg, 100mg, 200mg, da 400mg).
Sakamakon ya nuna cewa kowace magungunan lasmiditan ya inganta mahimmancin maganin ciwon kai (wanda aka kwatanta a matsayin ragewa a cikin matsanancin matsanancin zafi na migraine zuwa m ko a'a) a cikin sa'o'i biyu bayan ciwon kai, idan aka kwatanta da placebo.
Yayinda yake yi alƙawari a matsayin farfadowa, magungunan miyagun ƙwayoyi na iya zama nasarorin da ke tattare da cutar ta jiki, wanda mafi yawan mahalarta suka sami rinjaye yawancin laser.
Wadannan sakamako sun hada da:
Dizziness
Wulo
Vertigo (wani abin mamaki na walƙiya)
Rashin hankali
Darasi na biyu
Wani binciken na zamani na II a cikin Cephalalgia yayi nazarin gwamnatin intravenous (IV) na lasmiditan, wanda ke nufin an ba shi ta hanyar kwayoyin halitta. Masu halartar binciken suna da ciwon kai na matsanancin matsananciyar ƙwayar cuta na migraine kuma sun karbi kashi na IV na lasmiditan ko wani wuribo a asibiti.
Sakamakon ya nuna cewa a cikin kashi 20mg IV, saurin ciwon ciwon kai (sake bayyanawa a matsayin ragewa a cikin zafi zuwa m ko a'a a cikin sa'o'i biyu) ya kasance kashi 64 cikin dari kuma don placebo ya kasance kashi 45 cikin dari.
Abubuwa masu cutarwa irin su lagge, damuwa, da jin dadi (yawanci mabiya) sun fi kowa a cikin ƙungiyar lasmiditan fiye da rukuni na kaso (kashi 65 cikin kashi 43 cikin dari).
Menene Ma'anar Nazarin Zuka Biyu?
Duk waɗannan nazarin sun nuna cewa lasmiditan wani magani mai mahimmanci ne don magance ƙwayar migraines. Duk da haka, binciken yana haifar da al'amura na jurewa game da abubuwan da ke faruwa. Ana bukatar nazari mafi girma na shekara III don yin watsi da wadannan cututtuka masu illa gameda abubuwa kamar yadda waɗannan zasu iya iyakance dalilai don amfani da su a nan gaba.
Ta yaya Lasmiditan Works
Hakazalika da sauran magungunan ƙwayoyi na migraine, ainihin inji a baya yadda ayyukan lasmiditan ba cikakke ba ne.
Wannan ya ce, mun sani cewa yana kunna wasu masu karɓar sakonni a cikin kwakwalwa-kuma a cikin kwakwalwar ƙwayar ƙwayoyi, an gano matakan serotonin don ragewa.
Sauye-sauye , magungunan gargajiya da ake amfani da su don bi da ƙwayar ƙwayar cuta mai tsaka-tsaka-tsaka-tsaka, har ila yau yana ɗaure ga masu karɓa na serotonin. To, ta yaya lasmiditan na musamman daga masu cin nasara? Masana sun lura cewa lasmiditan ya fi zaɓaɓɓu fiye da masu cin nasara-ba ya ɗaure ga masu karɓar sakonnikan din din din din wanda, lokacin da aka kunna su, ya haifar da ƙaddarar jini (abin da ya faru).
A gaskiya ma, wannan mummunan sakamako (wanda ake kira vasoconstriction) yana da mummunan ƙeta ga masu cin nasara da kuma dalilin da ya sa aka saba musu a cikin mutane da tarihin:
- Ciwon zuciya
- Dama
- Kwayar cuta na jijiyoyin jini
- Halin ƙin jini wanda ba a sarrafa shi da magunguna
- Wasu nau'i na migraines (alal misali, migraine migrophil da migraine migraine)
Bugu da ƙari kuma, a cikin nazarin dabba, an gano lasmiditan don toshe alamomin da aka hade da motsawar wutar lantarki ta ɓarna. Wannan yayi daidai da layi tare da sababbin ra'ayoyin game da "dalilin da ya sa" baya bayan ciwon kai na ƙaura, wanda shine wannan ciwo ba shine tushen farko na karfin jini ba wanda yake kewaye da kwakwalwa, amma a cigaba da hanzarin ƙwayoyin hanzari.
Sabili da haka, lasmiditan rikitaccen ciwon ƙwayar cutar ciwon ƙwayar ƙwayar cuta kamar yadda ya saba da magungunan jini (jini). Wannan na iya bayyana dalilin da yasa bashi ba sa aiki ga wasu 'yan gudun hijira.
Sauran hanyoyin kwantar da hankali
Har yanzu yana da wuri don ya ce yadda lasmiditan zai ci gaba da tafiya, amma a kalla akwai sabon zaɓuɓɓukan da aka fara, kuma suna canza hanyar da muka fahimta yadda ƙirar ƙirar ke ci gaba. Alal misali, da zarar an fara aiki a cikin ƙaura, abubuwa masu kama da peptide-related peptide (CGRP) suna da alaka da su. Wadannan, bi da bi, suna fadada tasoshin jini a kusa da kwakwalwa. Magunguna da ke toshe ƙwayar sunadaran CGRP ko dai ta hanyar jingina ta kai tsaye ko ɗauri ga mai karɓarta yana cigaba, kuma karatun farko suna alamar.
Bugu da ƙari, kuma mafi mahimmanci sune na'urori (ba magunguna) da ke motsa wasu jijiyoyi, kamar naman farji ko kuma jijiyar supraorbital. Wadannan na iya zama zabi mai kyau ga mutanen da ba za su iya ɗaukar ko magance magungunan ƙwayoyi na ƙaura ba. Duk da haka, za su iya zama tsada da kuma inshora inshora zai iya zama batun.
Kalma Daga
Gaba ɗaya, babban hoto a nan shi ne cewa lasmiditan yana da mahimmanci a binciken ilimin biyu na II don jin zafi na ƙananan migraine. Amma, yana da mahimmanci a tuna cewa ana buƙatar karatu mai zurfi ( nazarin lokaci na III ) don ƙetare ƙarancin tsarin illa gameda abubuwa kamar yadda waɗannan zasu iya zama iyakancewa ga wasu mutane. Labari mai dadi shine akwai rajista ko karatun karatu na III na wannan lokaci.
> Sources:
> Aggarwal M, Puri V, Puri S. Serotonin da CGRP a Migraine. Ann Neurosci . 2012 Afrilu 19 (2): 88-94.
> Capi M et al. Lasmiditan don maganin ƙaura. Kwararre ta gano Investig Drugs . 2017 Feb, 26 (2): 227-34.
> Farkkila M et al. Ƙarfafawa da kuma jurewa na lasmiditan, mai maganin mai karba 5-HT (1F) mai maganin ƙwaƙwalwar ƙwayar cuta: gajiyar lokaci na biyu mai gudanarwa, wanda yake aiki tare da shi, nazarin kashi-kashi. Lancet Neurol. 2012 May, 11 (5): 405-13.
> Ferrari MD et al. M jiyya na migraine tare da mai zaɓin mai karɓa 5-HT1F agonist lasmiditan - gwaji na gwaji-of-concept. Cephalalgia . 2010 Oktoba; 30 (10): 1170-8.
> Mawallafi C Tfelt-Hansen, Olesen J. Magungunan mai karfin 5-HT1F mai kula da agonist lasmiditan a matsayin magani mai mahimmanci game da hare-hare na migraine: nazari na lokuta biyu na gwaji na wuribo-gwaji. J Headache Pain . 2012 Jun; 13 (4): 271-75.