Na al'ada faruwa, Sarkar, Tsari-Based, da Xenoestrogens
Estrogen ne muhimmin hormone dake sarrafa canje-canje a jikin mace. Wasu daga cikin waɗannan canje-canjen sun tabbata sosai, kamar su kare kasusuwan ku karfi amma kuma zasu iya haifar da ciwon ciwon nono. Mene ne ya kamata ka san game da irin abubuwan da ake amfani da su a cikin jikin mace, da isrogens, da isrogens, da xenoestrogens?
Menene Estrogens?
Estrogen ba kawai sinadaran kawai ba amma a maimakon haka rukuni na hormones ne da ke da alhakin ci gaban mace da iyawar yara.
Estrogen kuma yana taimakawa wajen daidaita yanayin sakewa , yana kare kasusuwa daga bakin ciki, kuma yana kiyaye ƙwayoyin cholesterol marasa ƙarfi don kare zuciyarka. Yayin da estrogen na da hormone na al'ada da ya kamata, sau da yawa wasu lokuta ana iya taimakawa yaduwar isrogen zuwa jikin jikin ƙirjin jikin.
Ba dukkanin estrogens ne aka samar a jikin mace ba, duk da haka, kuma kana iya saba da estrogens na roba a cikin kwayoyin haihuwa da kuma maye gurbin hormon. Jerin bai tsaya a can ba. Akwai phytoestrogens wanda aka fassara su ne a cikin "estrogens na shuke-shuke" da kuma xenoestrogens, mai yiwuwa estrogens wanda zai iya rayuwa a cikin duk abin da daga robobi zuwa gurbatawa.
Estrogens na halitta a cikin Jiki na Jiki
Irin nau'in estrogen a cikin jikin mace ya bambanta akan ko ta kasance mai farawa ne ko kuma wanda ya fara aiki. Akwai kuma siffofin daban-daban na estrogen a jikinka wanda aka sanya ta hanyoyi daban-daban.
Prerog Menopausal Estrogens
- Estrone (E1): Tsarin shine sanya a cikin ovaries kafin menopause. Bayan mazaunewa, an ajiye estrone a cikin jiki da tsoka. Mata da ke da ƙwayar jiki za su sami kwarewa a lokacin menopause, kodayake jikinsu yana adana fiye da mata fiye da mata. Harshen Estrone ya sauka a lokacin haihuwa, wanda ya rage yawan rayuwar ku zuwa ga estrogen. (Wannan shine dalilin da ya sa ciki yana da sakamako mai kariya akan ci gaban ciwon nono).
- Estradiol (E2): Kamar estrone, estradiol an yi a cikin ovaries. Yayin da ake ciki, akwai isasshen kayan samar da isradiol.
- Estriol (E3): Yayi wajibi ne a matsayin mahaifa a lokacin daukar ciki. Irin wannan estrogen ne aka samar a cikin mafi girma, fiye da estrone ko estradiol, a lokacin daukar ciki. Hanyoyin Estriol na nuna alamar lafiyar jariri
Estrogens Menopausal
Yayin da kake kusanci mazaunin mata , ovaries za su yuwu (atrophy) kuma samar da estrogen da progesterone za su cigaba yayin wannan tsari. Ƙananan ƙananan waɗannan hormones ne waɗanda ke haifar da hasken zafi , lokuta na yau da kullum, da suturar rana, saurin yanayi da sauran alamu. Doctors za su iya bi da waɗannan cututtuka tare da maye gurbin hormone (HRT) na ɗan gajeren lokaci, amma an yi amfani da tsawon lokaci tare da kara yawan ciwon nono.
Bayan mazaunewa, androgens (namiji na hormones) wanda wasu glanders suka haifar sun juya cikin kyallen takarda a cikin isrogen. Wannan shi ne abin da aka yi niyya ga mata masu ciwon kwakwalwa na ciwon estrogen receptor-tabbatacce. Harshen enzyme (furotin) wanda ke da alhakin canzawa da kuma torogens zuwa estrogen ana kiransa aromatase. Magungunan ciwon daji da ake kira masu kwantar da ƙananan aromatase (kamar Aromasin, Arimidex, da Femara) sun shawo kan ayyukan da wannan enzyme yake yi don kada a sake samar da isrogen.
An fitar da Estrogens a waje da Jiki
Akwai nau'o'i uku na estrogen da aka samar a waje da jikinka. Wasu suna halitta ta tsire-tsire, wasu suna cikin yanayin, kuma nau'in na uku ya haɗa da wadanda aka sanya su a cikin lab.
Phytoestrogens
Phytoestrogens ne tsire-tsire estrogens samu a tsire-tsire da kuma botanicals. Wadannan phytoestrogens zasu iya samun ciwon isrogen-like a jikinka lokacin da ka yi musu. Sakamakon shuka estrogens yana da rauni sosai fiye da isrogens wanda ovaries ya samar amma zai iya samun sakamako na asibiti.
Yana da rikice magana game da phytoestrogens. Sanin ciwon estrogen yana haɗuwa da haɗarin ƙwayar ciwon nono, wannan yana nufin kada ku ci tsire-tsire? Yana taimakawa wajen fahimtar cewa aikin aikin estrogens na tushen shuka ne da bambanci fiye da jinsin ganyayyaki na ovarian. A cikin jikinmu, phytoestrogens na iya samun nau'in estrogen-like ko ciwon haɓo-estrogen dangane da ƙayyadaddun nama.
Yana iya zama mai sauƙi don bayyana wannan ta hanyar lura da yadda cutar shan magani ta ƙwayar ƙwayoyi ta tamoxifen ke aiki. Lokacin da matan da suka kamu da ciwon daji na ciwon asrogen ne, wannan miyagun ƙwayoyi zai iya rage hadarin komawa. Tamoxifen yana ɗaure ga masu karɓar isrogen amma yana da cututtukan estrogen kamar yadda wasu kwayoyin cutar suke ciki da kuma ilimin estrogen na wasu. Tare da ƙwayoyin nono (da kwayoyin cututtukan nono), tamoxifen yana ɗaure ne a cikin mai karɓar isrogen din don isrogen ba zai iya ɗaure ba. Wannan aikin ya hana estrogen daga daura da kuma karfafawa ci gaban ƙwayar. A cikin sauran takalma, duk da haka, yana iya samun sakamako mai yaduran isrogen. Saboda ciwon hawan zane-zane yana da nasaba da kasusuwa, zai iya yin aiki don ƙarfafa ƙasusuwan kama da hanyar da zabin estrogen yake.
Wasu tsire-tsire da ke dauke da phytoestrogens sun hada da waken soya, jan cloak, wake, hatsi, da flaxseeds. Akwai abubuwa masu yawa na "halitta" da ke dauke da phytoestrogens wanda aka yi amfani da su don magance cututtukan mutumopausal. Yana da muhimmanci a lura da cewa wasu daga cikin wa] annan maganin ta ganye ba za a yi amfani da su ba, da mata masu fama da ciwon nono ko kuma a haɓakar haɗarin cutar.
Xenoestrogens
Xenoestrogens sun samo asali ne daga sunadarai da suke a cikin muhalli, da yawa daga cikinsu akwai kwayoyin halitta. Xenoestrogens sunfi girma fiye da isrogen da jikinka yake yi, kuma da yawa daga cikin wadannan mahaukaciyar zane-zane na zane-zane na iya haifar da tasiri a lafiyarka. Xenoestrogens suna cikin wani nau'i na mahadi da ake kira endocrin disrupting jamiái wanda ke jawo sha'awa da damuwa a yadda suke shafi jiki mutum a girma da ci gaba. Bisphenol-A samuwa a cikin wasu robobi ne daya misali.
Duk da yake bincike bai kasance cikakke ba, akwai tabbacin cewa wasu daga cikin wadannan mahadi zasu iya tsangwama ga ci gaban al'ada, haifuwa, kuma zai iya kasancewa mai hadari ga ciwon nono. Muna amfani da kayayyakin da ke dauke da xenoestrogens a kullum. Ana iya samuwa a wasu kwayoyi, kayan lantarki, magunguna, abinci, sabulu, da magungunan kashe qwari. Muhallinmu (ruwa, iska, ƙasa da tsire-tsire) ana gurɓata ta hanyar xenoestrogens daga fitarwa masana'antu da zubar da kayan da ke dauke da xenoestrogens.
Synthetic Estrogens
Sinawa sunadaran sunadaran sunadaran sunadaran sunadaran sunadaran sunadaran sunadaran sunadaran estrogen ne da aka sani da Ethinyl estradiol . Synthetic estrogens, kamar xenoestrogens, su ne mafi yawan ƙarfi fiye da estrogens na halitta. Ana iya samunsu a magungunan magunguna kamar su kwayoyin kwantar da haihuwa da kuma maye gurbin hormon.
Kafin 2002, an sauya tsarin maye gurbin hormone (HRT) don dalilan da dama kuma ana daukar su a matsayin kwayar mu'ujiza wanda zai iya jinkirta tsarin tsufa. Yana da matukar tasiri a rage cututtukan cututtukan mazaopausal kamar su walƙiya mai zafi da kuma busassun ƙasa, kuma ya bayyana ya taimaka tare da sauye-sauye yanayi kamar yadda ake yi a lokacin menopause. Bugu da ƙari ga sarrafawa na menopausal bayyanar cututtuka, an yi bikin domin iyawa don rage kashi bonening, da kuma la'akari da amfani game da cututtukan zuciya da kuma Alzheimer's.
Shirin Nazarin Harkokin Kiwon Lafiyar Mata na da aka buga a shekarar 2002 ya zama abin mamaki ga mata da likitocin su. Tsohon maganin miyagun mu'ujiza, yayin da har yanzu yana amfani da alamun cututtuka na mazaopausal basu da amfani ga rage cututtukan zuciya da shanyewa. Kuma mafi mahimmanci shi ne cewa HRT ta haifar da haɗarin ciwon nono. Tabbatar da wannan binciken, ƙananan ƙwayoyin cutar ciwon daji sun fara karuwa kamar yadda yawancin mata suka daina shan HRT.
Estrogens da ƙwayar cutar ciwon daji
Estradiol yana kara haɗarin ciwon daji na ciwon daji a cikin mata masu auren mata.
Kwayoyin maganin jijiyoyin haihuwa (kwayoyin maganin haifa) sun hada da isrogen, kuma akwai wasu kariya ga amfani da kwayoyi. Ga matan da ke fama da ciwon nono, gudanarwa na iya haifar da hadarin. Kwayoyin maganin haihuwar magungunan (kuma da wuya) suna hade da cututtuka da jinin jini (zurfin maganin thrombosis).
Ƙananan ciwon isrogen suna hade da ƙananan hadarin bunkasa ciwon nono. Yara na farko da yaro tun yana da shekaru 30 kuma yana da ƙananan yara suna haɗuwa da ƙananan haɗari (saboda rage samar da estrogens lokacin daukar ciki). Amma bayanin kula, shine, haɗuwa tana haɗuwa da ƙananan ƙananan ci gaba da cutar ciwon daji a ƙasa, amma cikakkiyar hadarin bayan haihuwa yana da kyau fiye da mata waɗanda basu da haihuwa.
Duk da yake likitoci ba su amfani da matakan yaduwar jini don gane da hadarin ciwon nono, yana da muhimmanci a gane muhimmancin wadannan kwayoyin cutar cikin haddasa ciwon daji. Don kula da tsarin estrogen na lafiya, likitoci sun ba da shawarar cewa kayi wasu matakai don rage yawan hadarin da ke ci gaba da ciwon nono:
- Kula da lafiya mai kyau
- Ƙayyade abincin ku
- Aiki a kai a kai
- Ka guji maganin hormone post-menopusal idan likitan ka zaton kana cikin hadarin
- Kula da idanu da kunnuwan ku don sanin ƙarin game da xenoestrogens. Yawancin waɗannan sunadarai sunyi wuya su guje wa, amma yin la'akari da hankali har sai mun san mafi yawan hikima. Akwai bincike mai zurfi a ci gaba kuma za mu iya sauraren karin shekaru masu zuwa. Nazarin kamar wanda yake kallon Bisphenol-A jawo wani maganin ciwon daji na nono ya nuna cewa muhimmancin xenoestrogens a ci gaba da ciwon ciwon nono yana buƙatar yin bincike mai kyau ne kawai a saman dutsen kankara.
- Idan kuna la'akari da yin amfani da kayan lambu na shan phytoestrogens, yi magana da ma'aikacin kiwon lafiya wanda yayi nazarin waɗannan kari. Akwai wasu likitoci da suka yi sha'awar haɗa waɗannan hanyoyin da suka dace tare da maganin gargajiya wanda zai taimake ka ka fahimci yiwuwar hadarin da wadata.
Sources:
> Fucic, A., Gamulin, M., Ferencic, Z. et al. Bayanin muhalli ga Xenoestrogens da kuma Estrogen Related Cancers: Tsarin haihuwa, nono, ƙwaro, koda, daɗa, da kuma Brain. Lafiya ta muhalli . 2012. 11Suppl 2): S8.
> Nagaprashantha, L., Adhikari, R., Singhal, J. et al. Hanyoyin Hanya na Hanyoyin Halitta Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsarin Harkokin Tsari. Jaridar Duniya na Ciwon Cutar . 2017 Oktoba 4. (Epub gaba da bugu).
Fuhrman BJ, Schairer C, Gail MH, et al. "Hanyoyin cutar ta Estrogen da kuma hadarin ciwon nono a cikin 'yan mata postmenopausal". Cibiyar Cancer ta Kasa. 2012, 326-339.
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