Ciwon kwayar cutar kwayar cutar ta HIV ya tashi zuwa Amurka
Tivicay (dolutegravir) wani mai amfani ne wanda ke hana maganin cutar HIV. Shi ne karo na biyu a cikin ƙungiyar masu haɗaka masu haɗaka don yarda da Cibiyar Abinci da Druggun Amurka (FDA).
An ba Tivicay izinin lasisi na FDA a ranar 12 ga Agusta, 2013, don amfani da tsofaffi da yara masu shekaru 12 ko tsufa wadanda suke auna akalla 88 lbs (40kg) kuma ba a taɓa magance su ba tare da hadewa.
(Tivicay ba a amince da ita ba ga yara a karkashin 12 kodayake gwaje-gwaje na asibiti na Phase III suna aiki don tantance lafiyarsa da inganci a cikin wannan shekara.)
Tivicay kuma wani bangaren ne na yau da kullum, maganin hade-hade mai lamba , Triumeq , wanda ya hada da kwayoyi abacavir da lamivudine. FDA ta amince da Triumeq a ranar 22 ga Agusta, 2014.
Binciken Bincike na Clinical Research
Binciken na VIKING-3 ya nuna cewa Tivicay yana da tasiri a cikin kashi 63% na marasa lafiya marasa lafiya da juriya da nau'o'i na kwayoyin cutar HIV, ciki har da masu hadewa mai suna Isentress (ratelgravir) da kuma elvitegravir (a cikin kwayar kwayar cutar guda daya, .
Binciken SINGLE ya nuna cewa marasa lafiya a Tivicay suna da mummunar tasiri na katsewa saboda mummunan magani da yafi Atripla (tenofovir + emtricitabine + efavirenz). Bayan makonni 48, kashi 2 cikin dari na batutuwa akan tsarin Tivicay sun dakatar da magani tare da 10% na wadanda ke karbar Atripla.
Yankewa
- Manya: 50mg kwamfutar hannu, sau ɗaya kowace rana
- Manya da wasu haɗin gwiwar mai haɗin gwiwa: 50mg kwamfutar hannu, sau biyu a kowace rana
- Yara 12 kuma a kan (yin la'akari 88 lbs / 40kg ko fiye): 50mg kwamfutar hannu, sau ɗaya kowace rana
Bugu da ƙari, ga yara da suke aiki da Sustiva (efavirenz), Aptivus (tipranavir) + Norvir (ritonavir), Lexiva (fosamprenavir) + Norvir (ritonavir), ko rifampin, kashi na Tivicay na 50mg, sau biyu a kullum.
Ba'a sani ba tukuna idan Tivicay yana da tasiri a cikin yara tare da haɗakar haɗin gwiwar mai hanawa.
Drug Administration
Tivicay za a iya ɗauka tare da ko ba tare da abinci ba, kuma a kowane lokaci na rana.
Hanyoyin Kasuwanci
Abubuwan da aka fi sani dasu (abin da ke faruwa a cikin 2% ko žananan lokuta) sune:
- Insomnia
- Ciwon kai
- Dizziness
- Jiɗa
Drug Interactions ko Incompatibility
Tikosyn (dofetilide), wanda aka yi amfani da shi wajen maganin arrhythmia (ƙwaƙwalwar ajiyar zuciya), an ƙin yarda don amfani da Tivicay.
Don kaucewa yin hulɗar miyagun ƙwayoyi da miyagun ƙwayoyi, ba da shawara ga likitan ka kake shan kowane magunguna ko magunguna masu biyowa:
- Magungunan antiretroviral : Sustiva (efavirenz), Harkokin (etravirine), Viramun (nevirapine), da haɗin Lexiva (fosamprenavir) + Norvir (ritonavir), ko Aptivus (tipranavir) + Norvir (ritonavir)
- Magunguna masu tsari: Trileptal (oxcarbazepine), Dilantin (phenytoin), Phenytek (phenytoin), Luminal (phenobarbital), ko magunguna na carbamazepine irin su Carbatrol, Equetro, Tegretol, Teril, ko Epitol
- Rivampin-tushen maganin rigakafi: Rifadan, Rifater, Rifamate, Rimactane
- Magunguna na ciwon sukari Metformin: Fortamet, Glucophage, Glumetza, Riomet
- St. John's Wort
Abubuwa
- Marasa lafiya da ke fama da rashin lafiyar bayan fara Tivicay ya kamata tuntube likitan su nan da nan . Dole ne a dakatar da magani kuma a nemi likita idan an sami raguwa tare da zazzabi, tsoka ko haɗaɗɗun haɗari, blisters or sores, redness ko kumburi da idanu, kumburi ko fuska, ko matsalolin numfashi. Marasa lafiya waɗanda suka rigaya suka sami maganin rashin jin dadin su ga Tivicay kada a sake kalubalantar su tare da miyagun ƙwayoyi bayan ƙaddamar da bayyanar cututtuka.
- Tivicay ya kamata a dauki sa'o'i biyu kafin ko sa'a shida bayan shan aluminum-ko magnesium-dauke da ƙarancin abu ko laxatives, karin kayan aikin ƙarfe, karin abincin sinadaran, magunguna, ko Carafate (sucralfate) amfani da su wajen maganin ulcers na duodenal.
- Sanar da likitan ku game da kowane hanta da za ku iya yi kafin ku fara Tivicay. Akwai yiwuwar haɗari ga ƙwayar hanta a wasu, musamman ga mutanen da ke da ciwon hauka B (HVB), hepatitis C (HCV) , ko ciwon hanta na gaba. Dole ne a kula da enzymes na haƙiƙa akai-akai a matsayin wani ɓangare na gwajin jini na yau da kullum na daukar Tivicay.
> Sources:
Ƙungiyar Ma'aikatar Medicine ta Amurka. "TIVICAY (dolutegravir sodium) kwamfutar hannu, mai rufi na fim." Bethesda, Maryland; sabunta watan Agusta 2013.
ViiV Lafiya. "Kamfanin kiwon lafiya na ViiV ya sami amincewar FDA ga Triumeq." London, Ingila; latsa wallafawa 22 Agusta 2014.
Walmsley S .; Antela, A .; Hoto, N .; et al. "Dolutegravir (DTG; S / GSK1349572) + abacavir / lamivudine sau ɗaya yau da kullum a kan mahimmanci na statoci zuwa tenofovir / emtricitabine / efavirenz: sakamako na 48-makon - SINGLE (ING114467)." 52nd taro na rashin jin daɗin ciki game da Antimicrobial Agents da Chemotherapy. San Francisco; Satumba 9-12, 2012; Abubuwan H-556b.
Nichols, G .; Grossberg, R .; Lazzarin, A; et al. "Ayyukan Antiviral na Dolutegravir a cikin Suhimmanci Tare da Rashin Gidawar Tsarin Maƙalar Bincike: Week 24 Farkon 3 Sakamako Daga VIKING-3." 11th Congress Congress on Drug Far in HIV Infection (HIV11). Glasgow, Scotland; Nuwamba 11-15, 2012; Abubuwan O232.