Biguanides sunaye ne na maganin ciwon sukari da ke amfani da su don magance cututtukan sukari na 2, wanda metformin shine nau'in nau'i. Wadannan kwayoyi suna aiki ne ta hanyar haifar da glucose wanda ya zo daga narkewa. Ba su haifar da hypoglycemia kuma ko da taimakawa tare da asarar nauyi da ƙananan lambobin cholesterol . Su ne mafi yawan kwayoyi da ake wajabta don ciwon sukari na 2.
- Har ila yau Known As: Metformin, Glucophage
- Biguanides: Tushen wadannan magunguna
- Metformin : Ƙara koyo game da yadda ake amfani da wannan magani.
Magunguna Biguanide don Ciwon sukari
Metformin shi ne babban abin da yake a kasuwa a kan kasuwa don shan magani. Glucophage (metformin) da Glucophage XR (metformin kara-saki) sune mafi sanannun waɗannan kwayoyi. Sauran alamun sunaye sun hada da Fortamet, Glumetza, da Riomet. Haka kuma yana samuwa a cikin kayan hade tare da wasu kwayoyi masu ciwon sukari.
Biguanides an fara samo daga Lila na Faransa, wanda ake kira goat's rue, Galega officinalis. Bincike akan tasirin da ya haifar da rage yawan glucose na jini ya haifar da ci gaba da ƙananan haɗari. Wasu magunguna na iya haɗawa da wannan shuka, amma idan kana amfani da magunguna na ƙwayar sukari ya kamata ka yi amfani da hankali saboda hulɗa.
Sauran nau'o'in biguanides sun ci gaba amma sun janye daga kasuwa. Wadannan sun hada da phenformin, wanda aka gabatar a 1957 a lokaci guda kamar yadda metformin amma ya janye a ƙarshen shekarun 1970 saboda an hade shi da babban hadarin lactic acidosis.
Wannan shi ne, rashin alheri, m a cikin rabin lamarin.
An kafa Buformin a Jamus a shekara ta 1957 amma ba a sayar da shi a Amurka ba. Haka kuma an gano cewa yana da haɗarin hadarin lactic acidosis. An cire shi daga kasuwa a mafi yawan ƙasashe amma ana iya samuwa a wasu.
Bugu da ƙari da amfani da shi ga ciwon sukari, wasu nau'o'in biguanides suna amfani da kwayoyi antimalarial, proguanil, da chlorproguanil.
Yaya Yayi Biguanides aiki don Ciwon sukari?
Metformin yana aiki don sarrafa yawan sukari cikin jininka. Ba zai shafi yawan insulin da kuke samarwa ba, amma yana kara yawan ƙwarewa ga insulin . Wannan yana taimakawa kwayoyin ku dauki glucose a cikin amfani don makamashi, rage rage samar da glucose a cikin hanta, kuma rage rage yawan glucose a cikin jini. Yin amfani da glucose a cikin hanji yana samar da lactic acid, wadda ke tattare da hanta amma zai haifar da sakamako na lactic acidosis. Metformin ba zai haifar da hypoglycemia na asibiti ba, wanda shine amfani akan wasu magunguna masu ciwon sukari. Har ila yau, bazai haifar da wadataccen kima ba kuma yana da tasiri masu kyau don rage wasu ƙwayoyin cututtuka na zuciya.
An umurci Metformin don ciwon sukari na iri 2 sau ɗaya idan ba za'a iya gudanar da cutar ta hanyar sauye-sauye na rayuwa kawai ba. Yana da magani na maganin, don haka za'a iya ɗauka a matsayin kwamfutar hannu ko ruwa. Dangane da nau'i, an ɗauki sau ɗaya zuwa sau uku kowace rana. Akwai samfurori da aka ƙaddamar da su da kuma siffofin da ake buƙatar dauka tare da abinci. Dole ne a bi umarnin don amfanin lafiya na kowace samfur.
Yayin da ciwon sukari ke ci gaba, za a iya yin rigakafi na insulin don sarrafa jini da kuma metformin har yanzu za'a iya amfani dasu don inganta ikon da mutum ke amfani da insulin.
> Sources:
> Bailey CJ, "Biguanides da NIDDM," Ciwon Ciwon Abun Cutar, 1992 Jun, 15 (6) 755-72.
> Metformin, MedlinePlus, Cibiyar Siyasa Magunguna ta Amurka, 2/15/2015
> Krentz AJ, Bailey CJ. "Magungunan antidiabetic maganganu: halin yanzu na irin ciwon sukari 2". Drugs. 2005; 65 (3): 385-411.