Thiazolidinediones sune magungunan magungunan da ke taimakawa rage zubar da jini a irin su 2 ciwon sukari . Bugu da ƙari da cin abinci mai kyau da motsa jiki, su ne wata hanyar da za a sarrafa matakan jini. Ana kuma san su kamar glitazones.
A Amurka, thiazolidinediones a halin yanzu sun hada da Actos (pioglitazone), Avandia (rosiglitazone), da kuma haɗarin Avandamet na bara (rosiglitazone da metformin).
FDA ta sanya takunkumin izini a kan rosiglitizone a shekarar 2013 bayan kammala sabon shaidu bai nuna rashin haɗari na zuciya ba, amma bans ya kasance a wuri a Turai.
Dos da Dont
Thiazolidinediones taimaka wajen rage insulin juriya a cikin sel, inganta hanyar da jiki amsa ga insulin. Suna yawanci karɓa baki ɗaya ko sau biyu a kowace rana. Bugu da ƙari, ana iya amfani da su kadai, tare da wasu kwayoyi, ko kuma tare da insulin. Thiazolidinediones ba su maye gurbin insulin a cikin jiki ba kuma suna motsa jiki don ƙirƙirar insulin. Ba'a nufin su maye gurbin abincin lafiya wanda likita ya bada shawarar ko dai.
Tarihin Amfani
Tun daga farkon shekarun 1990, an yi amfani da thiazolidinediones don bi da ciwon sukari 2. Na farko da ake amfani da kwayoyi a cikin wannan aji, Rezulin, an cire shi daga kasuwa na Amurka saboda matsalolin hanta amma mai tsanani. Wasu rahotanni sun tayar da damuwa game da kara yawan cututtukan zuciya a marasa lafiya ɗauke da Avandia.
Sauran rahotanni sun nuna yiwuwar ciwon zuciya tare da thiazolidinediones, ko da yake wannan mahadar ba ta da kyau.
Hukumar ta FDA ta umurce su, a shekara ta 2006, cewa wa] annan takardun miyagun ƙwayoyi na Avandia sun yi gargadi game da hadarin ciwon zuciya da kuma ciwo mai zafi a wasu marasa lafiya. Amfani da Avandia ya ragu bayan da aka bayar da gargadi na farko.
A shekara ta 2010 FDA ta ƙuntata sababbin takaddun umarni ga Avandia don kawai mutanen da basu iya kula da glucose na jini tare da wasu magunguna masu ciwon sukari ko wadanda basu iya daukar Dokar.
A shekara ta 2013, sakamakon binciken RECORD na gwagwarmaya ba ya kara yawan hadarin zuciya da Avandia (rosiglitazone). A sakamakon haka, a shekarar 2013, FDA ta kawo takunkumin da aka sanya a kan Avandia. Ranar 16 ga watan Disamba, 2015, FDA ta kawar da Gidawar Hanyoyi da Tsarin Gudanar da Harkokin Gudanar da Rsiglitazone da ke dauke da magungunan, kuma sun tabbatar da cewa amfanin da ya wuce hadarin.
Duk da haka, Hukumar Lafiya ta Turai ta dakatar da tallace-tallace na rosiglitazone a shekara ta 2010 da Faransanci da Ƙungiyar Magunguna ta Jamus kuma sun dakatar da amfani da pioglitazone (Actos) a shekarar 2011.
Hanyoyi da Hanyoyi
Abubuwan da suka shafi kwayoyin cutar sun hada da riba mai yawa, cututtuka na numfashi na sama, cututtuka na sinus , ciwon kai, da kuma mummunan anemia. Abubuwan haɗari masu tsanani sun haɗa da riƙewar ruwa, rashin ciwo zuciya, riba mai nauyi, da ciwon tsoka. Sauran cututtuka na iya haɗa da ciwon kai, high cholesterol, kasusuwa ƙasƙantattu, matsalolin ido da kuma amya.
Duk da yake babu wani shaidar da ke faruwa a yanzu da yake nuna cewa Actos ko Avandia na haifar da hanta, yana da kyau a ci gaba da kulawa da irin wadannan cututtuka irin su tashin zuciya, zubar da ciki, ciwo na ciki, gajiya, hasara na ci, jaundice (yellowing of skin and eyes), da kuma duhu fitsari.
Wanda bai kamata ya yi amfani da Thiazolidinediones ba
Mutane masu ciwon sukari iri daya (suna buƙatar ciwon insulin na yau da kullum), rashin zuciya zuciya, ko cutar hanta ba zai yi amfani da thiazolidinediones ba. Yara da masu juna biyu ko masu shayarwa ya kamata su guji yin amfani da wadannan magungunan. Mutane da ke da hankula ko ƙetare ya kamata suyi magana da masu kiwon lafiya kafin su ci thiazolidinediones.
Sauran "Ƙaƙƙin Labarin" Ana amfani
Ayyuka zasu taimaka wajen magance babban cholesterol. Thiazolidinediones na iya taimakawa wajen bunkasa kwayoyin halitta da haihuwa a polycystic ovary syndrome.
Abin da ba za a sani game da Thiazolidinediones ba
Thiazolidinediones ya kamata a dauka a kowace rana.
Suna iya ɗaukar watanni uku don ɗaukar cikakken sakamako. Idan mutum ya fuskanci duk wani sakamako mai illa, musamman kumburi, ƙimar nauyi ta hanzari, ƙwaƙwalwar numfashi, ƙwaƙwalwar zuciya, canjin yanayin mutum, ko ƙasusuwan da aka karya, sanar da likita a gaggawa.
Mutanen da ke fama da ciwon sukari, duk da haka, bai kamata su daina shan shan magani ba sai dai idan an umurce su suyi haka. Yana da muhimmanci a ga likita don kulawa da biye bayan kula da thiazolidinediones. Wannan ya haɗa da gwajin jini, gwajin aikin gwajin, da gwajin ido.
Sources:
Mahaffey, Kenneth W .; Hafley, Gail; Dickerson, Sheila; Burns, Shana; Tourt-Uhlig, Sandra; White, Jennifer; Newby, L. Kristin; Komajda, Michel; McMurray, John; Bigelow, Robert; Home, Philip D .; Lopes, Renato D. (2013). "Sakamakon sake dubawa na sakamakon cututtukan zuciya a cikin gwajin RECORD". Littafin Zuciya na Amirka 256 (2): 240-249.e1.
Drazen, MD, Jeffrey M., Stephen Morrissey, Ph.D., da Gregory D. Curfman, MD "Rosiglitazone-Ci gaba da rashin tabbas game da Tsaro." Jaridar New England Journal of Medicine. 357 (2007): 63-64.
FDA Taimakon Sadarwa ta FDA: FDA yana buƙatar kawar da wasu ƙayyadewa da kuma ƙuntatawa ga masu shan magunguna na rosiglitazone. FDA Newsroom. 11/25/2013. Cibiyar Abinci da Drug.
David K. McCulloch, MD. "Thiazolidinediones a lura da ciwon sukari mellitus," Dec. 17, 2015. UpToDate.