Magunguna da dama na IBD da ke Cibiyar TNF sunyi amfani da ƙumburi
Matsayin necrosis na Tumor (TNF) wani nau'i ne na furotin ne wanda aka sani da cytokine wanda kwayoyin jini sun fara . TNF yana da mahimmanci ga jiki domin yana taimakawa wajen tsara tsarin mayar da martani ga tsarin da ba a rigakafi ga wani abu na waje, musamman ga magungunan ƙwayar cuta. Yana inganta kumburi, yana samar da wasu kwayoyin da ake amfani dashi a cikin amsawar ƙwayar cuta, kuma zai iya taimakawa wajen warkar da kwayoyin halitta.
Ana kuma kira TNF a wasu lokuta a matsayin mai ƙwayar necrosis factor-alpha.
Me yasa TNF-alpha yana da muhimmanci a IBD?
TNF wata muhimmiyar mahimmanci ne game da maganin cututtukan cututtuka na huhu (IBD). An gano TNF a mafi yawan mutane da cutar Crohn fiye da mutanen da basu da cutar Crohn. Har ila yau, an gano TNF, zuwa ƙananan digiri, a cikin ɗakunan mutanen da ke fama da cutar. Saboda wannan ƙungiyar, ana tunanin cewa TNF tana taka muhimmiyar rawa wajen ci gaba da / ko ci gaba da cutar Crohn da ciwon cututtuka. Wannan shine dalilin da ya sa aka kirkiro kwayoyi da ake kira biologics don magance IBD da wasu yanayi mai kumburi. Gyara TNF yana nuna alamar wasu marasa lafiya a rage rage alamar cutar ta IBD da kuma warkar da ƙumburi a cikin ɓoye na hanji.
Sautin calprotectin da lactoferrin sune alamomi guda biyu da aka yi amfani dasu don kimanta ƙonewa na yanzu a cikin mutanen da ke da IBD. Wadannan sunadarai guda biyu za a iya auna su ta hanyar gwada jaririn.
An gano cewa idan akwai karin sunadarin sunadarai a cikin kwakwalwa, akwai ƙari a cikin hanzarin mutane tare da IBD. Lokacin da yawancin sunadarin sunadaran a cikin kwakwalwa, za'a sami warkarwa a cikin hanji. Hannar calprotectin da lactoferrin mafi ƙarancin zai iya nufin cewa magani yana aiki kuma wanda mai haƙuri yana gabatowa, ko yana cikin gafara.
Nazarin sun nuna cewa matakan calprotectin da lactoferrin sun kasance marasa lafiya a cikin marasa lafiya wadanda suka dauki magungunan TNF.
Daban-daban iri na TNF
Nazarin halittu sun nuna cewa akwai nau'o'in TNF, kuma an dauke TNF a matsayin "superfamily". Dabbobi daban-daban na TNF sun hade da wasu cututtuka, cututtuka, da kuma ciwon sukari. Gano iri na TNF da ke hade da yanayi na musamman zai iya taimakawa wajen magance cututtuka don magance cututtuka.
Ba duk wanda ke tare da IBD ya amsa da irin wannan kwayoyi ba a cikin hanyar. Wannan zai iya kasancewa, kuma yanzu an yi la'akari da shi ne ta hanyar masana, cewa akwai wasu subtypes na IBD. TNF na iya taka muhimmiyar rawa a wannan kuma, saboda wasu mutane da IBD sun amsa sosai ga magunguna na TNF, yayin da wasu mutane basuyi ba. Dabbar jini na wani TNF mai haƙuri zai iya haɗuwa da mafi girma ko ƙarami na mayar da martani ga wani magunguna na TNF. Wannan wani yanki ne na binciken, kuma har yanzu akwai ƙarin fahimtar TNF kafin a iya amfani dashi ga kulawa da haƙuri.
TNF-alpha A Colon Cancer
Har ila yau, TNF na da muhimmiyar mahimmanci wajen bunkasa ciwon ciwon daji da sauran cututtuka na ciki. Binciken da aka yi a TNF har yanzu ba shi da komai, amma yana iya bayar da wasu alamomi a cikin haɗuwa tsakanin cututtuka da kuma ciwon daji.
Anti-TNF-alpha Magunguna
Wasu jiyya na likitanci na Crohn sun hada da ci gaban TNF da kuma daura shi. Lokacin da aka gina furotin, ba zai iya samar da kumburi ba. Wasu magungunan TNF sune Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab pegol), Enbrel (etanceptcept), da Simponi (golimumab).
A Note Daga
Akwai sauran abubuwan da ba a fahimta ba game da TNF da dangantaka da yanayin ƙaddamarwa irin su IBD. Duk da haka, an yi amfani da kwayoyin anti-TNF da dama don amfani da mutane tare da IBD, kuma suna iya samun sakamako mai kyau don irin waɗannan cututtuka.
> Sources:
> Sipponen T, Savilahti E, Kärkkäinen P, et al. "Fecal calprotectin, lactoferrin, da kuma cututtuka na endoscopic a kula da maganin TNF-Alpha na cutar Crohn." Flamm Bowel Dis. 14: 1392-1398.
> Subramaniam K, Richardson A, Dodd J, et al. "Tsohon asali na kullun da kuma na tsawon lokacin gyaran gyare-gyare a cikin marasa lafiya na ciwon ƙwayar cuta da ke fama da cutar ta hanyar amfani da maganin necrosis na kwayoyin cutar." Ƙasa Mid Juli 2014 Mayu; 44: 464-470. Doi: 10.1111 / imj.12397.
> Taylor KD, Plevy SE, Yang H, et al. "Yanayin ANCA da dangantaka ta LTA na haɗin gwiwar LTA zuwa maganin maganin cutar ta TNF a cutar Crohn." Gastroenterology . 2001 May; 120: 1347-1355.
> Yang JP, Hyun MH, Yoon JM, et al. "Ƙungiyar tsakanin kamfanonin TNF-α-308 G / A da polymorphism da ciwon daji na ciwon sukari: nazari na yau da kullum da kuma bincike-bincike." Cytokine . 2014 Dec, 70: 104-114. Doi: 10.1016 / j.cyto.2014.07.005.