5 Matsayi na Farko amma Kyautattun Hanyoyin Kwayoyi

Wani lokaci miyagun ƙwayoyi suna yin amfani da amfani marasa amfani

Kalmar "sakamako na gefen" yawanci yana samun mummunan laba. Mutane da yawa suna tunanin cewa maganin ilimin likitanci na da kyau. Duk da haka, bisa ga Dokar AMA na Style , sakamako mai tasiri shine kawai "sakamako na biyu na farfesa (yawancin magungunan miyagun ƙwayoyi) wanda aka aiwatar don gyara yanayin likita" kuma yana iya kasancewa ko amfani ko mai cutarwa. A gefe guda kuma, "mummunar tasiri," "abubuwan da ke faruwa," da kuma "halayen halayen" sune sakamakon mummunan sakamako.

Ya kamata ya zama ba abin mamaki ba ne cewa da dama magunguna suna da tasiri waɗanda suka bambanta da yin amfani da su. Bayan haka, duk lokacin da aka cinye, wadannan kwayoyi suna yadawa cikin jiki kuma suna nunawa ga tsarin kwayoyin halitta, ciki har da tsarin ƙaddamarwa, numfashi, da kuma juyayi.

Ga wadansu abubuwa masu amfani da magunguna guda biyar da suka dace.

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Ci gaba da Girma

Proscar wani magani ne da ake amfani dasu don magance cutar hyperplasia ta prostatic (BPH) . BPH wani tsari ne wanda ke da glandan prostate (wanda aka samu a cikin maza) ya hana tsutsawa kuma haka yawo daga fitsari. BPH wani yanayi ne mai dadi, wanda zai haifar da bayyanar cututtuka, irin su urinary mita, rashin jinkiri, gaggawa da ragowar raguwa.

Proscar inhibits 5α-Reductase, wani enzyme na ciki wanda ya canza tuba ga testosterone zuwa dihydrotestosterone. A yin haka, Proscar ya rage girman prostate a cikin watanni kuma ya rage alamun bayyanar urinary.

Mai sashi mai aiki a Proscar ya zama wanda ya dace, wanda kuma shine mai aiki a cikin Propecia, wani magani da aka dauka don inganta ci gaba a cikin wadanda ke da launi na namiji . A wasu kalmomi, wani mutumin da yake ɗaukar Proscar don kula da BPH zai iya shafar girma.

Hakanan, maida hankali a cikin Proscar yana da mahimmanci fiye da yadda yake a cikin Propecia. A wasu sharuddan, mutanen da suke ɗaukar nauyin BPH na kai kimanin 5 MG kowace rana don tsawon watanni; Duk da haka, wadanda suke yin sulhu don asara gashi sunyi amfani da 1 MG kowace rana don tsawon watanni.

Da fatan a bincika tare da likitan ku kafin shan Proscar, Propecia ko wani magani na likita. Likitanka zai san abin da kwayoyi da jiyya, idan akwai, ya dace maka.

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Baclofen da Heartburn Relief

Baclofen ne mai laushi na tsoka mai ƙwanƙwara wadda ke hana jigilar reflexes a matakin ƙananan igiya. An yi amfani dashi don biyan adalcin tsoka . Spasticity ya shafi ci gaba da ba tare da so ba na daya ko fiye kungiyoyin tsoka. Labaranci yana haifar da rauni ko lalata (alal misali, palsy, sclerosis ko bugun jini) zuwa kwakwalwa ko ƙwararre.

Girman adasanci yana gudanar da gamut daga mummunan abu da kuma mummunan matsananciyar mummunan rauni da rashin aiki. Mahimmanci da yawa na iya haifar da kwangila, lalata, da kuma kwanciyar hankali (AKA matsa lamba ko matsin lamba).

Yana da mahimmanci don magance ladabi saboda wannan yanayin na iya haifar da ciwo, shafi yanayi, katse barci da rashin haɓaka motsi kuma ya kunyata ikon mutum na cin abincin rayuwar yau da kullum, irin su kiyaye tsabta, yin amfani da wanka, wanka, da cin abinci. Rashin kulawa da kyawawan halaye zai iya haifar da nakasar gurguzu, ko gyaran cutar, ciki har da kwangilar tendons da ƙananan tsokoki da kuma rage tsokoki.

Bugu da ƙari, zalunta da magungunan da ke tattare da bambancin kwayar halitta, irin su ciwo, damuwa, da spasms, baclofen na iya inganta sifofin cutar cututtuka na gastroesophageal (GERD) . GERD yana haifar da haɗuwa mara kyau na sphincter ƙarancin kasusuwan (LES), wadda take tsakanin sifa da kuma ciki kuma yana ba da izinin samun abinci tare da gastrointestinal tract. Lokacin da sphincter ƙananan kwakwalwa ya lalace yana da mawuyacin hali, abun ciki na ciki na ciki ya sake komawa cikin sifa wanda ya haifar da alamun GERD, kamar ƙwannafi, tari, ciwon makogwaro, ciwo da kirji da wahalar haɗuwa.

A wasu mutanen da ke tare da GERD, baclofen zai iya inganta alamar yanayin wannan yanayin domin shi ya hana ciyayi na RAI (TLESRs), musamman bayan cin abinci (postprandial). Sakamakon bincike ya nuna cewa wannan miyagun ƙwayoyi yana rage adadin TLESRs ta kashi 40 cikin dari A wani bayanin da ya shafi, jiyya na GERD tare da baclofen yana kashe-lakabi kuma yawanci an ajiye su ga mutanen da basu amsawa (su ne refractory to) magani na al'ada tare da masu zanga-zangar proton pump ( PPIs) .

Ya kamata a lura cewa ko da yake masu gastroenterologists sun lura cewa aikin GABA-B baclofen yana taimakawa tare da alamar GERD, a gwaji na asibiti, wannan sakamako ba ta kasance mai yankewa ba. A baya, wasu kamfanonin kamfanoni uku sunyi ƙoƙarin bunkasa GABA-B agonists don maganin GERD: AstraZeneca, Xenoport da Addex Pharmaceuticals. AstraZeneca ta lesogaberan sanya shi da furthest a gwaji na gwaji; duk da haka, masu bincike sun yanke shawarar cewa wannan magani bata taimakawa tare da GERD ba.

A yayin binciken kararraki, masu bincike sun nuna cewa dalilin da ya sa ba a tabbatar da asibiti mai amfani a gwajin gwagwarmayar AstraZeneca ba saboda yawan mutanen da ke cikin binciken sun bambanta. Masu binciken sun gwada gwagwarmaya a kan mutane da yawa tare da GERD na yaudara ga PPI. Maimakon haka, mafi yawancin mutane za a iya bayyana su da alamun bayyanar cututtuka (alal misali, ƙwannafi, tari ko jingina); sabili da haka, mahalarta sun hada da wadanda ke fama da matsananciyar raguwa, ko rikice-rikice, TlesRs masu tasowa a matsayin dalilin wannan reflux, kuma sun kasance masu rikitarwa ga maganin PPI.

A wasu kalmomi, mutanen da ke da GERD mai mahimmanci wanda matsin lambar ƙaddamar da yaduwar kasuwa ta kasuwa ne mai sauƙi, watakila bazai amfana da hakan ba daga magani tare da baclofen. Maimakon haka, baclofen zai iya taimaka wa mutane da tsananin kyamarar da suka fuskanci TLESRs bayan cin abinci. Wadannan TLESRs na iya haifar da digo a cikin ƙananan kwakwalwa ta jiki, wanda za'a iya ragewa ta amfani da baclofen.

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Viagra da Inganta Zuciya kwangila

Mun san cewa Viagra (sildenafil) yana taimaka wa maza su yi jima'i. Musamman, yana ƙara yawan jini ya zubar da azzakari ta hanyar jin dadi mai laushi. Bugu da ƙari da yin gyaran kayan aiki, Viagra na iya samun sakamako mai amfani sosai na inganta lafiyar zuciya.

Sakamakon sakamako mai mahimmanci na 2014 wanda aka buga a BMC Medicine ya bada shawarar cewa masu hana maganin phosphodiesterase 5 (PDE5), kamar Viagra, suna da kayan haɓaka da ƙila su iya inganta kwangila na zuciya (inotropism). Wadannan masu bincike sunyi tunanin cewa Viagra da sauran masu hanawa PDE5 na iya zama da amfani a zaluntar hypertrophy na cardiac da ɓatawar zuciya ta farko.

Daga bayanin kula, har yanzu muna da abu mai yawa don bunkasawa game da sakamakon PDE5 masu hanawa a kan zuciya. Duk da haka, yana da ban sha'awa a lura cewa amfanin Viagra zai iya wucewa ta ɗakin kwana.

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Kwayoyin maganin maganganun jijiyoyi da ingantaccen ƙwayar cuta

Yawancin matasan mata sun lura cewa ƙwayar ƙwayar cutar sun sami mafi alhẽri bayan sun dauki kwayoyin maganin maganin maganin maganin maganin maganin maganin maganin ƙwayar cuta (OCPs) don hana daukar ciki. Wannan cigaba ba daidaituwa ba ne kuma ana haifar da kwayoyin hormones a kwayoyin kwayoyin haihuwa-estrogen da progesterone.

A shekarar 2012, masu bincike na Cochrane Collaboration sun yi bincike don nazarin binciken da aka yi amfani da OCPs don maganin kuraje. Binciken su ya ƙare ciki har da 31 nazarin da 12,579 marasa lafiya. Binciken ya kasance mai karfin gaske kuma "idan aka kwatanta nau'i biyu na kwayoyin maganin haihuwa, kwayar cutar da wuribo ko" ƙugiya, "ko kwaya da kuma sauran maganin maganin kura."

Masu bincike sun gano cewa OCP suna da tasiri wajen rage ƙananan cututtukan ƙwayoyin cuta da marasa ciwon kumburi na biyu zuwa fuska. Bugu da ƙari kuma, masu bincike sun gano cewa, dangane da irin wadannan nau'o'in estrogen da progesterone dauke da su, wasu OCPs sun fi wasu a zaluntar kuraje. Alal misali, kwayoyin da ke dauke da acetate na cyproterone a cikinsu sunyi aiki da kyau fiye da wadanda suke tare da levonorgestrel.

Don Allah ka tuna, duk da haka, har yanzu ba mu san ko wane irin nau'ikan hormones da ke ƙunshe a cikin OCPs sun fi kyau a taimakawa tare da kuraje, kuma duk wata iƙirarin da cewa OCP ta bi da kararraki fiye da sauran, kamar yadda yake ba tukuna ba.

A wasu kalmomi, idan wani kamfanin OCP ya faru ya tallata cewa OCP yana aiki mafi kyau fiye da OCP na kishiya, to, kamar yadda yanzu, wannan ikirarin baya dogara akan tabbatar da shaidar kimiyya. A madadin, idan wani ya gaya maka cewa a halin yanzu OCP ta dauka yana taimakawa da ƙwayar cuta fiye da wani OCP na baya da ta dauka, babu wani tushen kimiyya na yanzu don wannan sanarwa, ko dai. Da yake sa ido, zai zama abin sha'awa don bincika irin nau'o'in OCPs zasu taimaka tare da alamar cututtuka na kuraje mafi.

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Levodopa da Creativity

A cikin shaidu na wallafe-wallafen likita, akwai tarihin dogon tarihi dangane da yanayin neuropsychiatric da kerawa. Magungunan likita sun dade suna kallon wasu sababbin basirar bayanan da suka shafi lalacewa, bugun jini ko lalacewa.

Magunguna, duk da haka, sun fara nazarin mahadar tsakanin mutane da ke dauke da levodopa da sauran kwayoyin kwayoyin cutar kwayoyin cutar kwayar cutar kwayar cuta ta kwayar cutar Parkinson da kuma bayyanar da kwarewa. Wannan sha'awar ta rushe shi ne ta asusun mutanen da ke fama da cutar Parkinson wanda bai taba rubuta littattafan wallafe-wallafen da waƙa da suka ci gaba da ba da izini ba. Bugu da ƙari kuma, mutanen da ke fama da cutar Parkinson wadanda suke shan damun kwayoyin cutar (Levodopa) an lura da su don su kirkiro zane mai haske a cikin launuka masu launi.

Yi la'akari da nassi na gaba daga takarda na 2013 da aka buga a cikin Neuroscience Behavioral , wanda ya bayyana game da rawar da kwayoyin kwayoyin halitta suka yi a matsayin masu haɓaka halitta:

"Yana da kyau sosai cewa duk sun ruwaito PD [kwayar cutar Parkinson] marasa lafiya da kerawar kwarewa da aka samu tare da wadanda suka hada da kwayoyin cutar dopaminergic ciki har da levodopa da agonist dopamine. Kodayake wasu marubuta sun nuna mahimmancin raunin rikice-rikicen ɓarna, irin abubuwan da suka faru da irin wannan lamari ya faru kuma tare da wadanda ba su da tushe. Ta haka ne alama ce da ake buƙata don samfurin sabbin kayan haɓaka ko ingantaccen ƙananan yarinya; [sic] shine gaban PD da kuma daukan hotuna ga levodopa da agonist dopamine. "

A bayanin karshe, dangantakar da ke tsakanin gwamnatin levodopa da kuma kerawa har yanzu, a wannan lokaci, ƙirar ƙira. Wasu dalilai na iya kasancewa a wasa, har ma da abubuwan da ke tattare da cututtukan kwayar cutar Parkinson da kanta, kamar zubar da ban sha'awa ko neman sabon abu.

Duk da haka, yana da wani abu da zai iya tunanin cewa maganin cutar ta Parkinson, ciwo mai ci gaba da tsarin mai juyayi wanda ya sa mutum ya motsa jiki, zai iya sa mai haƙuri ya halicci kyawawan fasaha. Bugu da ƙari, irin wannan fasaha na fasaha na iya bunkasa rayuwar mutum da kuma samar da aikin likitanci da ake buƙata ga waɗanda ke fama da cutar Parkinson.

> Sources:

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> Kahrilas PJ, Boeckxstaens G. Rashin ƙwaƙwalwa a cikin gwajin gwagwarmaya: miyagun kwayoyi ko marasa lafiya marasa lafiya? Postgrad Med. (89): 111-119.

> Maganin Drug na Mosby ga Ma'aikatan Lafiya na 2. St. Louis, MO: Mosby Elsevier; 2010.

> Rabow MW, Pan Slat. Gudanar da Kulawa da Ciwon Bincike. A cikin: Papadakis MA, McPhee SJ, Rabow MW. eds. Sanarwar Asibiti ta Yanzu da Jiyya 2017 . New York, NY: McGraw-Hill; 2016.