Yawan 'ya'yan inabi ne da aka sani don yin hulɗa tare da magungunan magungunan , yana ƙara yawan tasirin su a lokuta masu guba. Don haka, lokacin da ya zo Plavix (clopidogrel), magani na jini yana amfani da shi don rage yawan ciwon bugun jini da ƙananan ƙwayar cuta, to yana da lafiya ya cinye ruwan 'ya'yan itace? Amsar a takaice ita ce "a'a."
Yaya Hanyoyin Harsar Gishiri ke hulɗa da Plavix?
Binciken binciken da aka yi a shekarar 2014 ya samo kwayar cututtukan kwayar cutar CYP3A4, wanda clopidogrel ya zama substrate, da kuma CYPC19 enzyme, wanda ya hada da miyagun ƙwayoyi.
Yawan 'ya'yan itacen inabi zai iya tsangwama tare da juyawar clopidogrel zuwa tsari mai karfi, saboda haka rage yawan maganin rigakafi na miyagun ƙwayoyi da ake bukata domin hana cutar bugun jini ko ciwon zuciya.
A cikin jiki, clopidogrel ana amfani da ita ta amfani da enzyme CYP2C19. Duk da haka, wasu mutane ba su da matukar magungunan ƙwayar cuta ta CYP2C19. Wadannan mutane suna da tsayayya ga clopidogrel. Ko da yake akwai gwaje-gwaje na jini don gano marasa lafiya na clopidogrel kafin su kafa farfadowa tare da magani, wannan gwaji ba a amfani dashi ba. Daga bayanin kula, mutanen da suke fama da clopidogrel metabolizers, ma sun kara yawan haɗarin haɗarin mutuwa na cututtuka na zuciya da jijiyoyin jini.
A cewar wani rahoto na FDA, wasu magungunan zuciya da kwayar gwargwadon ruwan ke hulɗa da sun hada da:
- statins (kamar Zocor da Lipitor)
- Magunguna masu maganin jini kamar nifedipine
- magungunan anti-arrhythmia kamar amiodarone
Bugu da ƙari, magungunan zuciya, ruwan 'ya'yan ganyayyaki yana shafar wadannan kwayoyi:
- magunguna amfani dashi ga kwaya dashi kamar cyclosporine
- anti-anxiety magunguna kamar buspirone
- antihistamines kamar Allegra
Yaran ruwan inabi zai iya kasancewa mai lafiya na kowane abincin. Idan kun kasance a kan magungunan zuciya, don Allah ku tattauna ko yana da kyakkyawan ra'ayin shan ruwan inabi tare da likitan ku ko wani likita.
Tabbatar sanar da lafiyar ku na lafiyar dukkanin magunguna da kuke shanwa da kuma maganin waɗannan magunguna.
Kalma Daga
Yana da kyau koyaushe a hankali karanta aikin buga wanda ya zo tare da clopidogrel. Ya kamata a sami sashi game da hulɗar tsakanin clopidogrel da sauran magunguna. Idan ba ku sami saitin kunshin ba, ku tambayi likitan ku don kwafin.
Idan kana yin amfani da magungunan ƙwayoyin magungunan (OTC) ko karin kayan abincin, kuyi magana da likitan ku da likita game da hulɗar hulɗa. Ya kamata ku kasance musamman da hankali game da yin amfani da magunguna don ƙonewa kamar ibuprofen da OTC kari da cewa dauke da ginkgo. Sakamakon sakamako na waɗannan samfurori yana zub da jini.
> Sources:
> Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Ruwan tumatir ya hana da kunnawa na clopidogrel. Clin Pharmacol Ther . 2014 Doi: 10.1038 / clpt.2013.192
> Krasowski MD. Pharmacogenomics. A: South-Paul JE, Matheny SC, Lewis EL. eds. CURRENT Fahimtarwar & Jiyya: Family Medicine, 4e . New York, NY: McGraw-Hill; 2015.
> Trevor AJ, Katzung BG, Kruidering-Hall M. Pharmacogenomics. A cikin: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. Katzung & Trevor's Pharmacology: Nazarin & Board Review, 11th . New York, NY: McGraw-Hill; 2015.