Hanyoyin Vitamin C na iya dogara akan Malignancy
Lokacin da kake tunanin damuwa, watakila zuciyarka ta juya zuwa jigilar lokaci, jinkiri, gwaje-gwaje, dangantaka, ko wasu matsalolin da mutum zai fuskanta a rayuwa. Kasashen duniya a yau ba su da raunin matsalolin da suka faru.
Duk da haka, ba kowane mutum ya amsa daidai da wannan hanyar ta hanyar muhalli ba. Maganar bambancin mutum mai yiwuwa ne mai yawa, a wani bangare saboda ƙwarewarmu mu jimre da amsawa ta dace da yanayin mu.
Akwai salon salula wanda ya dace da danniya, kazalika. Kamar dai yadda muke iya gano yanayin mu musamman damuwa a wasu lokuta, yanayin tantanin halitta zai iya kawo nau'i daban-daban na damuwa - misali, kwayar da ke cikin ruwaye, ko rashin yiwuwar aiwatar da kwayoyin cellular ciki da kyau.
Yayin da kake tunani game da kwayoyin cutar Kankara, musamman, ba za ka iya haɗa su da sauri ba tare da halayyar da za a iya ɗauka. Ana kwatanta kwayoyin cutar kankara da kalmomi irin su 'marasa rinjaye' da 'm' a cikin abin da suke son haifuwa da yada ba tare da iyaka ba. Sai dai ya juya, duk da haka, cewa kwayoyin ciwon daji suna aiki a ƙarƙashin matsananciyar damuwa, musamman mawuyacin abu. Kuma bitamin C na iya taka muhimmiyar rawa idan yazo da wasu enzymes wanda ke taimakawa kwayoyin su amsa gajiya.
Mene Ne damuwa mai mahimmanci?
Mawuyacin haɓaka , a cikin ƙayyadaddun magana, rashin daidaituwa ne a cikin salon salula.
Yayin da ake ci gaba da zance, wannan rashin daidaituwa za a iya kallonsa azaman rikici tsakanin samar da magungunta (cututtuka kyauta) da kuma karfin jiki don magance cutarwa na wannan makiya (ta hanyar antioxidants).
Kuna iya koyi game da abubuwa masu kyauta a cikin ilmin sunadarai: bisa ga al'ada, an bayyana su kamar wasu kwayoyin da ba a kyale su ba, wadanda yawanci sune masu gamsarwa da gajeren lokaci, tare da masu zaɓin lantarki waɗanda ba a biya su ba.
Alal misali, kwayoyin oxygen a cikin jiki a wasu lokuta sun rarraba cikin nau'o'i guda ɗaya na oxygen, kowannensu tare da masu zaɓin lantarki marasa kyauta.
Electrons suna so su zama nau'i-nau'i, don haka wadannan maras tabbas, yanzu ana kiran su free radicals, neman wasu electrons da suke cikin jiki, kusan kamar masu tsattsauran ra'ayi, don haɗa tare da wani lantarki da yake da wani sauran kwayoyin a cikin jiki. Wannan danniya ne na oxyidative, sa'an nan, kuma yana haddasa lalacewar kwayoyin jikinsu, da membranes, sunadarai da DNA.
Don haka, me yasa kwayoyin cututtuka suna aiki a ƙarƙashin matsayi mai mahimmanci na ƙwayar cuta? Da kyau, sau da yawa waɗannan kwayoyin suna da matakan 'yanci na kyauta a asali, don farawa, kafin su zama magungunan. Bayan haka, yayin da tantanin halitta yake daukar matakai da yawa don zama mai sauyawa, abubuwa sukan canzawa dangane da yadda cell ke gudanar da kansa, wanda zai iya haifar da maɗaukaki masu yawa na radicals free.
Yawancin lokaci, akwai daidaituwa a tsakanin kyauta na kyauta da kawarwa. Akwai ƙungiya guda biyu daban-daban, tare da wata ƙungiya ta samar da samfurori kyauta kamar mahaukaciyar superoxide (O2-), hydrogen peroxide (H2O2), hydroxyl radicals (OH-), da dai sauransu, da kuma sauran kungiyoyin da ke samar da hanyoyin kare hankalin antioxidant [superoxide dismutase ( SOD), catalase (CAT), glutathione peroxidase (GPx), da dai sauransu].
Lokacin da abokin gaba na kyauta ba shi da kyau ko kuma an shafe ta, sakamakon zai iya zama lalacewar lalacewa, tare da hasara aiki da mutuntaka na tantanin halitta, da kuma lalata DNA, inganta ƙwayar halittar kwayoyin yiwuwar cututtuka da ci gaban kwayar halitta marar kyau. Wannan sakamako na ƙarshe ne da aka sani da rashin lafiyar kwayoyin halitta, kuma zai iya ƙara man fetur zuwa wuta kamar yadda ya dace da tafiya mai kyau.
Hanyoyin cututtuka da kuma danniya sunadarai sun hada da wasu cututtukan cututtukan mutane ba tare da ciwon daji ba, ciki har da cututtukan zuciya, cutar Alzheimer, cutar Parkinson, da sauransu. Har ila yau, akwai hanyar haɗi zuwa tsufa, tare da haɗuwa da hankali na lalacewa mai lalacewa.
Abubuwan da ke samar da kyauta masu kyauta za a iya samuwa a cikin muhalli, ciki har da abincin da muke ci, amma kuma suna faruwa a cikin jikinmu azaman samfurori na halitta na metabolism.
Yaya abubuwa da za su iya zama kamar Vitamin C Kare Kare Ciwon Cutar?
An gwada Vitamin C a wasu bincike game da magani da rigakafin ciwon daji; Duk da haka, sakamakon har yanzu ba koyaushe kullin hoto mai kyau ba. Amsoshin tambayoyi game da muhimmancin bitamin C akan rigakafi da magani zai iya dogara ne akan ƙananan malignancy - da kuma bitamin C, tare da wasu dalilai.
A ƙananan ƙananan, bitamin C yana da raunin antioxidant, hana hanawawan abu. Abincin antioxidant, mai arziki a cikin ascorbic acid (bitamin C), carotenoids (bitamin A) da kuma tocopherol (bitamin E), selenium, da flavonoids, suna bada shawarar saboda aikin da suke yi na hana yin amfani da iskar shaka da kuma samar da kyauta.
Duk da haka, ƙananan bitamin C na iya kara yawan kayan aiki na ATP (samfurin mitochondria) wanda ke haifar da mutuwar kwayar halitta a gwajin gwaje-gwajen tumo, ta hanyar tsarin samar da kwayoyin halitta.
Nazarin ya nuna irin ciwon daji da ke dauke da kwayar cutar ta hanyar ciwon daji da kewayar tsarin salula, tare da ƙara yawan kwayar cutar kanjamau a cikin gwaje-gwajen da suka magance ciwon daji tare da mitoxantrone (maganin cutar shan magani) tare da bitamin C .
Shin Za a Yi Matsayi na Gwanin Vitamin C a Cikin cutar sankarar bargo?
Ya zuwa yanzu, wasu nazarin sun ba da shawara game da cutar kanjamau, amma wasu nazarin sun nuna cewa bitamin C na iya sa chemotherapy ba shi da tasiri.
Amsar da take da ita ita ce "watakila," kuma ma, "yana iya dogara ne akan cutar sankarar bargo." Yana da mahimmanci a duba bitamin C daga kusurwa daban daban kafin a yanke shawarar game da amfani da shi a kowane ciwon daji, amma wasu Sakamakon farko daga binciken nazarin ilmin lissafin ilimin likitoci suna karfafawa.
Wani bincike na 2017 game da sakamakon bitamin C a kan cutar sankarar bargo an buga shi a "Labaran" mujallo. A cikin gabatarwar su, marubuta sun lura cewa hujjojin bitamin C a matsayin magani mai mahimmanci ga ciwon daji ya ci gaba da rikici har yanzu.
Vitamin C May Impact Enzymes Mahimmanci a cutar sankarar bargo
Musamman, wannan rukuni na masu bincike sunyi nazarin kwayoyin canzawa a cikin wani enzyme da ake kira Tet (Goma goma sha ɗaya) methylcytosine dioxygenase 2, ko TET2. Sun sami hulɗa mai ban sha'awa tare da bitamin C da wannan haɗarin enzyme-interactions wanda ya zama kamar inganta ingantaccen maganin ciwon daji. Wannan shi ne nazarin dabba, don haka abubuwan da ke faruwa ga mutane ba a san su ba tukuna, amma sakamakon ya kasance m.
A cikin jiki, sabon jini yana fitowa ne daga ƙwayoyin jiki a cikin kututtukan launin fata wanda ake kira sel kwayoyin hematopoietic. Nazarin farko sun nuna cewa ƙwayar cutar TET2 na iya sa wadannan kwayoyin halitta suyi girma cikin jiki, cikakke, na al'ada jini-kwayoyin jikinsu wanda ya mutu har ma kamar sauran tantanin halitta. Sabanin haka, a cikin cutar sankarar bargo, ƙwayoyin sel ba su girma cikin kyau ba, amma suna yin kamala, suna ninkawa a cikin clones mai cutarwa na kwayoyin kamarar copycat.
Sakamakon irin wannan cutar sankarar bargo yana haifar da ci gaban kwayoyin halitta shine ya hana jiki daga samar da isasshen al'ada, kodoyin jinin lafiya (misali, neutrophils, lymphocytes) cewa tsarin kulawarmu yana buƙatar yaki da kamuwa da cuta; ƙananan jini na jini zai iya haifar da anemia, kazalika. Saboda haka, mai yiwuwa ga kamuwa da kamuwa da cuta da abubuwa kamar rauni ko kodadde daga anemia na iya kasancewa cikin alamu da alamun cutar cutar sankarar bargo.
To, yana nuna cewa a wasu lokuta da cutar sankarar bargo, an samu canjin yanayi, ko maye gurbi, wanda zai haifar da wata sifa na TET2 wanda ba ya aiki yadda ya kamata. Ta haka binciken binciken na 2017 yayi nazarin hanyoyin da za a iya amfani da wannan enzyme, TET2, don yin aikinsa, kuma musamman ma, ko za a iya amfani da bitamin C ko a'a a cikin wannan ƙoƙari don mayar da lafiyar jini.
Vitamin C TET2 Sakamakon binciken
Masu bincike sunyi amfani da kwayar halitta ta hanyar sarrafa kwayar cutar TET2, kuma sun gano cewa lokacin da aka kashe TET2, kwayoyin jikinsu sun fara aiki, kuma idan sun sake dawowa, sai a sake dawo da wadannan ayyukan.
A cikin cutar sankarar bargo da wasu cututtuka na jini waɗanda za su iya rinjayar da canjin kwayoyin da suka shafi tasirin TET2, kawai ɗaya daga cikin nau'i biyu na TET2 ya canza. Masu bincike sun duba ko bitamin C zasu iya yin amfani da tsarin mummuna, musanya, ko gurɓataccen mahaifa ta hanyar ƙarfafa aikin kwafin da yake aiki akai-akai. Sun gano cewa tare da bitamin C, akwai bunkasa ga tsarin kwayoyin da ya mayar da aikin TET2.
Masu amfani da PARP-inhibitors kamar olaparib sune kwayoyi da ake nazarin don amfani da su a cikin daban-daban na cutar jini da cutar sankarar bargo. A cikin wannan binciken, masu bincike sun hada da bitamin C tare da masu zanga-zangar PARP a cikin tsarin dabba don nazarin hulɗar. Sun gano haɗin haɗin aiki ya fi dacewa, yana sa shi ya fi wuya ga ƙwayoyin Leukemic suyi suyi sabuntawa.
Menene Game da Vitamin C a Lymphoma?
Kamar yadda aka gano a cutar sankarar bargo, bincike a halin yanzu a cikin mataki na farko, yana nufin cewa abin da muka sani yazo ne daga gwaje-gwajen kwayoyin halitta da dabbobi a cikin dakunan gwaje-gwaje, amma ba mutane a cikin gwaji.
Duk da haka, akwai, dangane da waɗannan bayanan asibiti, dalilan da za su gaskata cewa binciken da aka danganta da TET2 da bitamin C zai iya zartar da akalla wasu lokuta na lymphoma .
A lymphoma, ana samun sauyawa TET2 mafi yawa a cikin lymphomas T-cell. A cikin lymphoma subtype, lymphoma T-cell angioimmunoblastic , TET2 za a iya canzawa cikin kashi 76 cikin dari na marasa lafiya. Sakamakon gyaran TET2 ya karu da kashi 38 cikin 100 na marasa lafiya da lymphoma T-cell-ba a kayyade ba, a cewar wani binciken da Lemonnier da abokan aiki suka yi, da kuma kashi 13 cikin dari na babban lymphoma B-cell .
Kalma Daga
Yayinda masana kimiyya ke rarraba bayanai game da bitamin C da kuma yiwuwarsa wajen rigakafi da maganin wasu cututtuka, yana da muhimmanci mu zama matsakaici a cinye wannan bitamin. Mafi yawan abu mai kyau ba dole ba ne har yanzu abu mai kyau. Kuma, yana da mafi kyawun lokaci don tuntuɓi likitanka lokacin da ka fara wani tsarin da zai iya tsoma baki tare da maganinka.
Babu wani shaidu da ya nuna cewa ƙarawa tare da bitamin C a kan ka, bayan abin da aka bada shawarar, zai sami sakamako mai kyau ko kuma amfani mai amfani a cutar cutar sankarar jini ko lymphoma, kuma irin wannan gwaji zai iya haifar da cutar a wasu lokuta.
A cikin binciken da suka wuce, an nuna cewa marasa lafiya da rashin lafiya na rashin lafiya suna iya zama marasa ƙarfi a bitamin C. Saboda haka, gyara duk wani rashin rashi na bitamin C wanda zai kasance yana da kyau mafi kyau.
> Sources:
> Cimmino L, Dolgalev I, Wang Y, et al. Maidowa na TET2 aiki tubalan sake sabunta kai da cutar cutar sankarar bargo. Cell . 2017 Aug 16. Koma: S0092-8674 (17) 30868-1. Doi: 10.1016 / j.cell.2017.07.032. [Afubu gaba].
> Lemonnier F, Couronne L, Parrens M, et al. Sauye-sauyen TET2 a cikin tantanin halitta T-cell lymphomas sun haɗa da siffofin TFH-kamar da magungunan asibiti. Jinin jini. 2012; 120: 1466-1469.
> Mikirova N, Casciari J, Rogers A, et al. Hanyoyin kwayar cutar C-intravenous na ciki a kan ƙumburi a marasa lafiya marasa lafiya. J Transl Med . 2012; 10: 189.
> Shenoy N, Bhagat T, Nieves E, et al. Daidaitawar aiki na TET tare da ascorbic acid yana haifar da epigenetic ƙaddamarwa na kwayoyin lymphoma. Ciwon Cutar Canji J 2017; 7 (7): e587-. Doi: 10.1038 / bcj.2017.65.