Pseudomonas Aeruginosa Yayi Mai Girma a Mutum tare da CF
Kimanin kashi 60 cikin dari na mutanen da ke dauke da cystic fibrosis suna fama da cututtuka na numfashi wanda ake kira Pseudomonas aeruginosa. Wannan kwayoyin sun fara shiga cikin ƙananan ƙwaƙwalwar kamala. Da zarar Pseudomonas aeruginosa ya mamaye fili na numfashi, yana da wuya a kawar da shi. Rashin ciwo na numfashi wanda ya haifar da kamuwa da cuta shi ne babban dalilin mutuwa a yawancin mutane tare da CF.
Kwayoyin Pseudomonas aeruginosa na zaune a kusa da mu. Wannan kwayoyin sun wanzu a cikin yanayi mai laushi kamar kewaye da ƙasa, shuke-shuke, nutsewar ruwa, shawagi har ma da takalman wasan tennis. Yawancin mutane sun hadu da Pseudomonas aeruginosa kowace rana ba tare da kamuwa da su ba. Duk da haka, a cikin mutanen da ba su da kwarewa ko kuma a cikin mutane da fashewa a cikin fata ko gashin fata, wannan kwayoyin zai iya haifar da kamuwa da cuta.
Bugu da ƙari da haɗawa da mutane tare da CF, Pseudomonas aeruginosa yana haifar da mummunan cututtuka tare da marasa lafiya da ke karbar cutar chemotherapy . A cikin 'yan shekarun nan, kamuwa da cutar Pseudomonas aeruginosa ta hanyar haifar da wasu fiye da CF ya ragu; Duk da haka, matsalar rashin lafiya tsakanin mutanen da CF ya kasance ba canzawa ba.
Ta Yaya Biyayyar Pseudomonas Aeruginosa?
Shekaru da suka wuce, yawancin kamuwa da cutar Pseudomonas aeruginosa a cikin mutanen da ke CF yana magance shi da rashin maganin rigakafi ko maganin maganin maganin rigakafi .
A karshen shekarun 1990 an samo asibiti na tobramycin kwayoyin, ko TOBI, musamman don maganin cututtuka na Pseudomonas aurginosa na numfashi. TOBI yanzu shine maganin wannan kamuwa da cuta kuma yana da magani wanda aka tsara a cikin mutane da cystic fibrosis.
Menene TOBI?
TOBI ya kasance daga tobramycin. Tobramycin ne kwayoyin aminoglycoside da ake amfani dashi don biyan Pseudomonas aeruginosa kamuwa da cuta. Wannan kwayoyin suna aiki ne ta hanyar rikici tare da kwayar sunadaran gina jiki. Ta hanyar yin magana tare da kira mai gina jiki na Pseudomonas aeruginosa, TOBI ta rushe kwayar jikin kwayar halitta da envelope don haka haddasa mutuwar kwayar halitta.
Mene ne TOBI Podhaler?
An yi amfani da TOBI da farko ta amfani da nebulizer . Nebulizer wani inji ne wanda ke haifar da iskar gashi don inhalation. A shekara ta 2013, FDA ta amince da TOBI Podhaler, wanda shine busassun foda mai ƙanshi wanda ya cika da foda tobramycin. Wannan sabon magani ya sa ya fi sauƙi ga mai haƙuri ya dauki tobramycin
Shin TOBI ga kowa?
Abin takaici, TOBI ba ga kowa ba ne. Mutane da ke fuskantar matsalolin matsalolin, matsaloli na koda, da matsalolin neuromuscular ya kamata a sanya TOBI sosai a hankali. Mafi mahimmanci, aminoglycosides sanannu ne tare da ji, kodan da kuma cutar da cutar neuromuscular fiye da na myasthenia gravis. Bugu da ƙari, mutanen da suke da kyamara ("rashin lafiyan") ga aminoglycosides kada su dauki TOBI. A ƙarshe, tobramycin, wanda shine mai aiki a cikin TOBI, yana da tayi kuma zai iya cutar da tayin a cikin mata masu ciki.
Source:
Smith, AL "Ingantaccen Ciwon Kwayoyin Kwayoyin cuta: Menene Drug? Menene Yayi? Menene Dokar? Abin da Halitta? "" Journal of Cystic Fibrosis . " 2002 1: S189-S193. 22 Yuni 2008.
Ramphal R. Damala Saboda Pseudomonas Dabbobi da Abubuwan da Suka shafi Shiga. A: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. Ka'idodin Magungunan Ciki na Harrison, 19th . New York, NY: McGraw-Hill; 2015.