Abubuwan da na IBD May sun hada da Genetics da muhalli
Masana kimiyya basu san abin da ke haifar da cututtukan zuciya ba (ICD) , wanda ya ƙunshi cututtuka na ƙwayar cuta, cutar Crohn, da kuma cututtukan da ba a san su ba. Ana la'akari da cutar "cututtuka", ko cutar tare da wata sananne. Duk da haka, akwai hanyoyi da dama game da asalin IBD, da kuma yanayin da zai taimaka wajen cigabanta.
Ba mu san ainihin abin da ke haifar da IBD ba, duk da haka, muna da wasu alamu, da kuma ra'ayoyin da yawa. An yi la'akari da cewa akwai wani kwayoyin halitta zuwa IBD, kuma wani abu (ko fiye da ɗaya) a cikin muhallin yana rinjayar kwayoyin da suke hade da IBD. Wannan yana iya "haifar da" IBD, kuma ya zama farkon bayyanar cututtuka. Duk da yake masu bincike sun koyi abubuwa da yawa game da kwayoyin da za a iya danganta da IBD, shi ne ɓangaren da ke da wuya a raba shi. Yanzu an yi tunanin cewa akwai daruruwan nau'o'in IBD, kodayake har yanzu muna raba su a cikin 3 sassa don muyi magunguna da su. Akwai kuma, a gaskiya ma, sun kasance daruruwan ko dubban mawuyacin hali. Wasu bincike sun nuna a wasu hanyoyi saboda dalilin da wasu mutanen da ke da kwayoyin halitta na IBD sun bunkasa IBD da sauran mutane ba.
Genetics da IBD
Shekaru da suka gabata, an yi tunanin cewa IBD zai iya gudana a cikin iyalai, amma haɗin yana da matukar damuwa saboda ba hanyar kai tsaye ba ne a kan iyaye-da-yara, kamar yadda yanayin yake da wasu gado.
Tare da ganowar yanzu nau'in kwayoyin da za a iya hade tare da IBD, ya zama fili cewa akwai wani abu wanda aka raba shi zuwa IBD. Abokan farko na mutanen da ke da IBD sun fi dacewa da cutar. Duk da haka, mafi yawan mutanen da ke da IBD ba su da tarihin iyali , don haka ba kowa yana da dangin da yake da cutar.
Saboda haka, yayin da IBD ke gudana a cikin iyalai, ba kawai batun da za a yi la'akari ba yayin da yake kallon yiwuwar yiwuwar IBD. Dole ne ya kasance wani abu dabam da ke sa wasu mutane da irin wannan kwayoyin suke bunkasa IBD, yayin da wasu ba su.
Abubuwan da ake kira IBD na Inflammatory Response
An kira IBD sau da yawa cutar cututtuka , wata cuta wadda ta samo asali daga tsarin rigakafi, amma ya fi dacewa a faɗi cewa yana da martani ne a cikin rikici. Saurin yanayi na yanayi - tun lokacin bazara ko kaka-wani lokaci yakan faru a cikin mutane tare da IBD. Ɗaya daga cikin ka'idar shine cewa wannan amsa amsa rashin lafiyar IgE ne .
Maganin rashin lafiyar ya sanya jerin abubuwan da suka faru wanda ya haifar da wuce hadari na eosinophils (kwayoyin da ke kokarin magance amsa rashin lafiyar jiki) a jiki. Wadannan eosinophils sun saki wasu magunguna masu guba guda uku, uku daga cikinsu ana samun su a cikin adadi na marasa lafiya na IBD. Wannan ya haifar da wasu masu bincike don gane cewa amsa rashin lafiyar zai iya taka rawar gani a ci gaban IBD.
Cytokines
Wani bangare mai zurfi na bincike shi ne muhimmancin da cytokines ke takawa a ci gaban IBD. Sel da ake kira ƙwayoyin necrosis na tumo (TNF, ko kuma wani lokacin da ake kira mai ƙwayar necrosis factor-alpha) suna da alhakin yin gyaran tsarin amsawa, tsakanin sauran ayyuka.
Ana samo TNF a mafi yawan mutane a cikin mutanen da ke tare da IBD fiye da yadda suke cikin mutanen da ba su da IBD (ta hanyar gwaji na calprotectin). Da fara tare da amincewar Remicade a shekara ta 1998, an kafa wasu magungunan TNF da ake kira "biologics" don magance IBD. Nasarar wadannan magungunan sun jawo nauyi a bayan ra'ayin cewa TNF tana taka muhimmiyar rawa a cikin hanyar IBD ko ƙumburi da ke haɗaka da IBD flare-ups.
Ayyukan Muhalli a IBD
Akwai wasu ka'idodi masu kyau a cikin annoba na IBD wanda zai iya nunawa ɗaya ko fiye da ƙwayoyin muhalli. IBD tana tsammanin ya faru sau da yawa a ƙasashe masu tasowa kuma daga waɗanda ke da matsayi na zamantakewa mafi girma.
Har ila yau, kamfanin na IBD, ya tanadar faruwa, a cikin birane na} asashe masu tasowa. Wadannan dalilai sun jagoranci masu bincike suyi tunanin cewa akwai dangantaka tsakanin IBD da dabi'un rayuwa ko yanayi na mutanen da ke zaune a kasashe masu tasowa, ko da yake babu wanda ya san duk abin da wannan zai iya zama.
Daya ya nuna ka'idar ita ce, kasashe masu masana'antu suna "tsabta sosai" , kuma saboda yara da yara suna nunawa kwayoyin halitta marasa ƙaran, matakan su na iya zama marasa inganci, wanda zai haifar da cututtuka na asibiti.
A Note Daga
Ba mu san ainihin abin da ke haifar da IBD ba, amma mun sani cewa ba abin da ya rage ta abinci ko damuwa. Akwai fili wani nau'in kwayoyin halitta wanda yake gudanarwa a cikin iyalai, amma wannan bangare na biyu, wani abu da ke kewaye da mu shine "haifar da" kwayoyin da ke tabbatar da wuya a samu. Gaskiyar ita ce, mun san yanzu yanzu game da IBD fiye da yadda muke yi har ma shekaru goma da suka gabata. Ana gudanar da bincike mai yawa, kuma masana kimiyya suna kusa da su don fahimtar yadda za mu iya magance wadannan cututtuka yadda ya kamata kuma mu hana su a cikin al'ummomi masu zuwa.
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