A wasu, masu hana hana ACE kamar lisinopril zai haifar da tari da kumburi.
Angiotensin-musanya masu haɗarin enzyme (masu hana ACE) kamar lisinopril, captopril da enalapril su ne magunguna masu guba. Masu hana ACE suna da tasiri a rage yawan karfin jini kuma sau da yawa sun fi so zuwa wasu zabin kamar beta-blockers (tunanin propanolol). Duk da haka, wasu mutane a kan masu hana ACE sun bunkasa tsokawar tari ko rashin rashin lafiyan-maganin fuska da fuska, baki da harshe (angioedema) wanda ke sa shan wadannan magunguna da wuya ko ma m.
Menene Masu Shayar ACE?
Masu hana ACE sun toshe sashin enzyme na angiotensin wanda ke juyawa angiotensin na zuwa angiotensin II. Ta hanyar hana wannan mataki na dole a cikin tsarin renin-angiotensin , masu maganin ACE suna iya rage yawan karfin jini ta hanyar vasoconstriction da rashin lahani na aikin aldosterone.
Aldosterone wani hormone steroid ne (mineralocorticoid) wanda gwargwadon ƙwayar jiki (zona glomerulosa) ya samar, wanda ke zaune a kan kodan ku. Aldosterone yana sarrafa tsararru na fitsari ta nephrons na koda. Musamman, aldosterone yana aiki ne don kawo sodium da ruwa a cikin wurare dabam-dabam don musayar potassium wanda aka cire kuma an fitar dashi. Bayanin kulawa, kamar yadda dokokin osmosis ya fada, kiyaye sodium da ruwa ƙara yawan karfin jini.
Ga wasu misalai na masu hana ACE:
- lisinopril
- captopril
- perindopril
- enalapril
- benazepril
- fosinopril
Ana hana masu hana gizon ACE kamar lisinopril don magance hauhawar jini ko cutar hawan jini kuma suna da tasiri sosai a cikin mutanen da ke fama da cututtukan koda da ciwon zuciya.
Ana amfani da masu hana masu kwakwalwa ta ACE wajen maganin ciwon bugun jini, ciwon zuciya, rashin tausayi na zuciya da kuma hana abubuwan da ke faruwa a zuciya na gaba. Ya kamata a lura da cewa a cikin ma'anar haka, masu maganin ACE-kamar wasu magunguna masu guba-ba su da tasiri a rage yawan karfin jini da kuma hana karar ciwon jini da kuma ciwon zuciya a cikin jama'ar Amirka.
Ga mafi yawancin, masu hanawa na ACE suna da lafiya kuma sunyi haƙuri. Idan an dauki shi fiye da haka, duk da haka, masu hanawa na ACE suna haifar da hypotension ko hawan jini mai tsanani kuma suna rage jinkirin zuciyarka (bradycardia), kuma. Lokacin da mutum ya taso da ƙananan jini zuwa ƙananan magunguna na ACE, an dakatar da mai hana ACE kuma an ba da ruwa don kawo matsalolin baya. (Ba a buƙaci magunguna su sake sake gina jini ba.)
A cikin wadanda ke da raunin kididdiga ko kuma wadanda ke ɗauke da NSAID (kwayoyi kamar aspirin), masu hanawa na ACE na iya daidaita matakan jikin salts ɗinku wanda zai haifar da hyperkalemia ko matakan potassium . Hyperkalemia ya zama mummunan saboda shi ya sa zuciyarka ta yi nasara kuma zai kashe ka. Bayan nan da nan da aka dakatar da mai maganin ACE, ana kula da wannan hyperkalemia a asibiti ta yin amfani da kwayoyi irin su calcium, insulin da glucose da sauransu.
Masu maganin ACE, Angiodema, da Cough
A karkashin yanayi na al'ada, angiotensin-converting enzyme karya saukar da bradykinin, wani mai matsin lamba mai ƙin ƙuriƙwalwar tunani ya zama dalilin ƙananan tari da ƙumburi gani a kimanin kashi 25 cikin waɗanda ke shan lisinopril da sauran masu hana ACE. Irin wadannan halayen sun fi yawa a cikin jama'ar Amurka
A cikin wadanda suka ci gaba da maganin rashin lafiya, irin maganin rashin lafiyar, an hana mai hana ACE da kuma steroids da diphenhydramine (Benadryl) don sarrafa kumburi. Irin wannan kumburi zai iya zama gaggawa na likita saboda yana iya toshe hanyar jirgin sama ɗinka kuma zai iya faruwa a kowane lokaci yayin da masu hanawa ACE. A wasu kalmomi, za ku iya ɗaukar masu zanga-zangar ACE kafin wani lokaci kafin ku sami angioedema.
Wani tari da masu maganin ACE ya haifar ba buƙatar magani ba sai dai katsewa daga miyagun ƙwayoyi. Masu hana ACE suna da gajeren rabi da raguwar rarraba kuma ya wanke daga gare ku a cikin rana.
Idan kai ko ƙaunatacciyar suna shan mai hana ACE kamar lisinopril da ciwon tari, don Allah sa lokaci don ganin likitanka don kimantawa. Likitan likitanku zai iya dakatar da mai hanawa na ACE kuma ya fara da kai a kan wani magani na antihypertensive kamar ARB (mai kwakwalwa mai karɓar angiotensin II).
Idan kai ko wanda kake ƙaunata yana jin dadin cutar angioedema da damuwa da rai yayin da ke cikin mai hana ACE, kada ka dauki karin magani sai ka kira 911. Bayan jiyya tare da steroids da Benadryl, likitanka zai iya kimantawa kuma ya rubuta wani magani don hawan jini . Lura cewa wannan miyagun ƙwayoyi ba zai zama ARB ba saboda ARBs an san su da wuya a sa angioedema, ma.
A bayanin ƙarshe, wasu halayen halayen da ke iya haifar da masu hana ACE kamar jini da ƙananan jini da nakasa na rashin lafiya (hyperkalemia) yawanci ana haifar da overdose, magani (NSAID) hulɗa ko aikin koda mai tsanani wanda ya canza rashin yarda. Sabili da haka, yayinda kake daukar masu hana ACE, tabbatar da kula da jini na gaba, biye da likitanka kuma tuntuɓi likitanka idan ka taba jin daɗin ciki, mai haske, mai juyayi ko sauransu.
Sources
Atkins G, Rahman M, Wright JT, Jr. Babi na 70. Binciken da kuma Kula da Tsawan jini. A: Fuster V, Walsh RA, Harrington RA. eds. Hurst's Heart, 13th . New York, NY: McGraw-Hill; 2011. Samun damar Afrilu 18, 2015.
Hayashi SA. Babi na 10. Angiotensin Blockers da ACE Masu hana. A: Olson KR. eds. Cigaba da Drug Overdose, 6th . New York, NY: McGraw-Hill; 2012. Samun shiga Afrilu 18, 2015.