Sabon Gwajin Drug ya nuna wa'adin maganin Hyperkalemia
Wani sabon magani da ake kira Patiromer ya nuna alƙawarin yin maganin hyperkalemia a cikin mutanen da suke shan magunguna na renin-angiotensin-aldosterone (RAAS). Hyperkalemia yana barazanar barazanar rayuwa kuma yana haifar da rauni, hauhawar rashin lafiya, rashin ciwo na numfashi, da rashin ciwon zuciya.
Wani lokaci, mutanen da suke tare da hyperkalemia, ko matakan potassium a cikin jini, a cikin ɗakunan shan magani.
Wadannan mutane sune tsofaffi da yawan cutar ciwon sukari kuma suna tare da hyperkalemia bayan da suka dauki magunguna na renin-angiotensin-aldosterone (RAAS) (β-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptors blockers [ARBs], da kuma altasterone receptor antagonists) A cikin wa] annan marasa lafiya da rashin ciwon hauka ko kuma masu ciwon sukari ne, za a iya ƙara matakan potassium zuwa matsala masu girma bayan gwamnati ta hana masu hana RAAS, wanda zai iya amfani da potassium daga haɗari a cikin fitsari.
Mafi yawa, duk da haka, hyperkalemia wani abu ne da yafi yawan gabatarwa a tsakanin marasa lafiya marasa lafiya da aka haɗu da wadanda suka hana RAAS don ciwon zuciya, da ciwon sukari, da kuma cututtukan koda. Ciwon sukari da kuma na kullum koda cutar haifar da atherosclerosis da glomerulosclerosis, bi da bi; wadannan matakan da ke tattare da kwayoyin halitta suna aiki tare don hana jiki (koda) damar kawar da potassium.
Kodayake masu hana RAAS su ne masu cin hanci da potassium kuma zasu iya haifar da matakan potassium ko hyperkalemia, ƙin zuciya, cutar cututtukan da ciwon sukari suna bi da su tare da masu hana RAAS. Saboda haka, zai zama da amfani ga hanyar da za ta fi dacewa mu bi da hyperkalemia a cikin mutane tare da waɗannan yanayin waɗanda suke ɗaukar masu hana RAAS.
A halin yanzu, an yi amfani da hyperkalemia kawai tare da matakan wucin gadi irin su beta agonists, calcium, ko insulin da glucose, duk wanda ya sa potassium a cikin sel; madauki ko thiazide diuretics, duka biyu sune masu cinyewar potassium da karuwa da potassium; wata miyagun ƙwayoyi da ake kira sodium polystyrene sulfonate (Kayexalate), wanda zai iya haifar da hypomagnesemia, hypokalemia, ciwo mai tsanani da gastrointestinal har ma da ciwon zuciya necrosis; da kuma dialysis. A lokacin gwaje-gwaje na 3 na gwaji, Patiromer yana rage matakan potassium a marasa lafiya da cutar cututtuka na masu ciwon sukari wanda suke shan masu hana RAAS kuma suka ci gaba da zama mai tsanani ga mai tsanani hyperkalemia.
Anyi amfani da fasti na polymer wanda ke wucewa ta hanyar gastrointestinal tract unabsorbed. Yayinda yake wucewa ta hanyar gastrointestinal tract, yana tsotsa potassium. A cikin gwaje-gwaje na asibiti, an nuna Patiromer lafiya da kuma tasiri ga dukan mako 52 a cikin mutane da hyperkalemia da ciwon sukari, wanda ya nuna cewa yana da mahimmancin kulawa. A wasu kalmomi, mutanen da ke hana masu hana RAAS iya kauce wa hyperkalemia ta hanyar shan Patiromer. Bugu da ƙari, bayan mahalarta sun dakatar da shan Patiromer, sai suka hanzarta bunkasa hyperkalemia. A wani bayanin da ya danganci, a cikin wasu nazarin, an nuna Patiromer don hana hyperkalemia a cikin mutanen da ke da ciwon zuciya wanda suke daukar masu hana RAAS.
Magunguna da ke shan Patiromer sun bayar da rahoton wasu cututtuka masu haɗari ciki har da damuwa da cututtukan koda, hypomagnesemia, damuwa da hawan jini da ciwo na gastrointestinal. Duk da haka, duk da haka, kawai kashi 10 cikin 100 na masu halartar wannan binciken sun daina yin Patiromer saboda wadannan cututtuka.
Duk da alkawalin da Patiromer ya nuna a lokacin gwaji na gwaji 3, wasu masana sun bayyana damuwa game da miyagun kwayoyi. Na farko, waɗannan masana sun nuna cewa zai zama kyakkyawan ra'ayin ci gaba da gwaji na Patiromer har tsawon shekara guda - bayan haka, wasu zasu bukaci su rage sauran rayukansu a kan Patiromer yayin da suke karbar masu hana RAAS.
Abu na biyu, ba shi da tabbacin ko masu daukan masu hana RAAS da Patiromer don hyperkalemia suna amfana daga jiyya tare da masu hana RAAS kamar yadda wadanda ke da matakan potassium (normokalemia) waɗanda ke shan masu hana RAAS.
Idan kana da wasu tambayoyi game da Patiromer ko wani magani, sai ka yi alƙawari don tattauna waɗannan damuwa da likitanka. Don Allah a tuna cewa likitanku mai kula da tausayi ne wanda ya kamata ya taimaka maka ka kasance mai ilimi da kuma sanar da kai. Karatu game da kwayoyi da jiyya akan Intanit hanya ce mai kyau don kiyaye kanka. Duk da haka, wannan ilimin ya kamata ya dace da kula da shawara da likitanku ya bayar.
> Sources:
> "Hanyoyin Patiromer a kan Ciwon Gurasar Ciwon Gurasar Maganin Ciwon Lafiya A Ciwon Hyperkalemia da Ciwon Gurasar Ciwon Abun Cutar Kwayar Sample Clinical Trial" ta GL Bakris da mawallafin da aka wallafa a JAMA a 2015.
> "Gudanar da Hyperkalemia Daga" Hyper K "" Gwajiyar Gida zuwa Gidan Gida? " da WC Winklemayer ya buga a JAMA a 2015.