Amfani da Drug, Mahimmanci, da Takaddun shaida
Epzicom wani maganin hade ne mai maganin kwayar cutar da ake amfani dashi a maganin cutar HIV, wanda ya hada da magunguna guda biyu, abacavir (Ziagen) da lamivudine (Epivir). Dukkanin magungunan magungunan sunadaran sunadaran magungunan transcriptase (NRTIs) kuma sunyi aiki ta hanyar hana wani enzyme da ake buƙata don kammala kirkirar DNA a kwayar cutar.
Ta hanyar yin haka, HIV ba zai iya canzawa ba kuma yada zuwa wasu kwayoyin halitta.
An yarda da Epzicom don amfani da manya da Cibiyar Abinci da Druggun Amurka (FDA) a ranar 2 ga Agusta, 2004. A waje da Amurka, an sayar da miyagun ƙwayoyi a ƙarƙashin sunan kasuwanci Kivexa .
Drug Formulation
An samo Epzicom a cikin kwamfutar hannu tare da 600mg na abacavir da 300mg na lamivudine. Shafukan da aka haɗe da fim din sun kasance a cikin siffar, orange, kuma sun kasance tare da "GS FC2" a gefe daya.
Dosages
Ɗaya daga cikin kwamfutar yau da kullum ana daukar baki tare da ko ba tare da abinci ba. Ba a taɓa yin nazari a kan kansa ba kuma dole ne a yi amfani da ita tare da daya ko fiye da maganin antiretroviral.
Hanyoyin Kasuwanci
Hanyoyin da ke cikin haɗarin amfani da Epzicom (faruwa a har zuwa 9%) sun hada da:
- Drug hypersensitivity ( duba a kasa )
- Insomnia
- Dama
- Ciwon kai / ƙaura
- Dizziness
- Jiɗa
- Diarrhea
- Rash
- Fever
- Abun ciki na ciki
Yawancin cututtuka suna da matukar damuwa duk da cewa mutane da alamun cututtuka na kamuwa da miyagun ƙwayoyi suna bukatar neman gaggawa.
Drug Hypersensitivity Gargaɗi
A wani lokaci ana lura da cututtukan ƙwayar cuta a marasa lafiya waɗanda ke nuna wa miyagun ƙwayoyin maganin ƙwayar cuta kamar yadda ya kamata, kuma zai iya zama m idan aka bari ba tare da izini ba. An bayyana ta biyu ko fiye daga cikin wadannan alamun alamun biyar masu zuwa:
- Fever
- Rash
- Gastrointestinal bayyanar cututtuka (tashin zuciya, zawo, vomiting, zafi na ciki)
- Rashin ciwo, malaise, gajiya, jijiyoyin jiki / haɗin gwiwa
- Hanyoyin cututtuka na numfashi (kwatsam na tsoka, rashin ƙarfi na numfashi, ciwon makogwaro)
Magungunan cututtuka na kamuwa da cutar kullum suna bayyana a farkon makonni shida na daukan hotuna, ko da yake zasu iya bayyana a kowane mataki na amfani da miyagun ƙwayoyi. Kullum magana, duk da haka, mafi yawan cututtuka na hypersensitivity faruwa a cikin kwanaki 10 na farko ko haka.
Idan an yi la'akari da kyakwalwar cutar, an dakatar da Epzicom nan da nan . Dole ne marasa lafiya su tuntuɓi likitan su da / ko su je asibitin su na kusa ko dakunan gaggawa ba tare da bata lokaci ba.
Kafin a fara farfasa da abacavir, an umurci likitoci don nunawa ga HLA-B * 5701 yayin da marasa lafiya da wannan halayen kwayar halitta suna da mummunan haɗari ga cututtukan cututtukan abacavir.
Bincike na asibitoci sun nuna cewa kimanin kashi 8 cikin dari na marasa lafiya a kan abacavir zasu fuskanci wani abu mai tsabta, wani lokacin tsanani.
Contraindications
- Previous abacavir hypersensitivity: Marasa lafiya da cututtuka na baya zuwa ga (Ziagen) abacavir kada a ba da umurni Epzicom.
- Raunin hawan: Masu fama da rashin lafiya na hanta (hanta) ya kamata su guje wa Epzicom. Don Allah a ba da shawara ga likitan ku idan kuna da ko kuma ake zargi da irin wannan rashin hanta, ko kuma idan an kamu da ku (ko ake zargin kuna da cutar) tare da hepatitis A, hepatitis B, ko ciwon haifa C. An bayar da rahoton tsananin cutar hepatitis B a cikin kwayar cutar kanjamau na HIV, yayin da wasu marasa lafiya a kan ciwon hakar C da ke dauke da interferon da / ko ribavirin na iya samun mummunan bayyanar cututtuka.
Drug Interactions
- Ethanol (shan barasa): jinkirta kawar da abacavir daga tsarin
- Methadone (aka yi amfani da shi wajen maganin maganin narcotic): rage rage tasirin ƙwayar ƙwayar cuta a cikin ƙananan yawan masu haƙuri
Ana ba da shawara cewa marasa lafiya sun rage yawan shan barasa yayin da suke a Epzicom, yayin da marasa lafiya a kan ƙwayar cuta suyi shawara ga likita idan an tsara Epzicom.
Ra'ayin Nazarin
Marasa marasa lafiya da koda (koda) bazai sanya wa Epzicom rubutun ba idan haɓakar halittar creatinine ta kasa 50mL / minti daya. A cikin marasa lafiya tare da hadarin ƙwayar ƙwayar kullun, sun haɗa da ƙididdigar creatinine, magani na phosphorus, furotin glucose da furotin furotin lokacin yin gwaje-gwaje na yau da kullum .
Yayin da wasu nazarin dabba sun nuna matukar haɗarin rashin ciwo na tayi a cikin berayen da zomaye da aka lalata ga abacavir ko lamivudine, babu irin wadannan bambance-bambance da aka ruwaito a cikin mata masu ciki da aka fallasa da kwayoyi da wadanda suke cikin jama'a.
A cikin ƙasashe masu tasowa, an bayar da shawarar cewa iyaye masu fama da kwayar cutar ta HIV sun guje wa nono domin yaduwar cutar HIV zuwa ga jarirai.
Sources:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta amince da maganin maganin cutar ta HIV-1 da ke tattare da kwayar cutar." Silver Spring, Maryland; bayar da Agusta 2, 2004.