Harkokin Hadin Kasa tsakanin Tsarin Halitta da Muhallinka
A matsayin rashin lafiyar mutum, plaque psoriasis ya kasance wani abu na asiri a yadda yake haifar da cutar. Duk da yake kwayoyin suna taka muhimmiyar rawa, wasu abubuwa ana ganin zasu taimakawa. Abin da muka sani shi ne cewa wasu yanayi da halaye na iya haifar da bayyanar cututtuka na psoriasis ko ƙãra mita ko tsananin fashewa. Suna kariya daga cututtuka zuwa kiba, magunguna don ƙarfafawa.
Genetics
Tarihin iyalan shine babbar hanyar hadari don tasowa psoriasis. A gaskiya ma, game da kashi uku na mutanen da psoriasis suka shafi za su bayar da rahoto tare da wani dan uwan da ke cikin cutar. Hasarin psoriasis yana da alama idan iyaye biyu suna da shi.
Duk da yake masana kimiyya basu riga sun kafa irin yadda kwayoyin suke aiki ba, sun gano wurare tara a kan wani jinsi da ke dauke da psoriasis bayyanar cututtuka, wanda sun lakabi PSORS1 ta hanyar PSORS9. Daga cikin waɗannan, kimanin kashi 35 zuwa kashi 50 cikin mutanen da ke da psoriasis na plaque zasu sami maye gurbin chromosomal na PSORS1.
Ana sa ran cewa ta hanyar karya ka'idar kayyade, masana kimiyya zasu iya "kashe" wata rana ko gyara gyaran da suka shafi cutar.
Ƙwararrun Yanayin
Duk da yake plaque psoriasis zai iya rinjayar kowa, akwai wasu dalilai da yawa wadanda suka bayyana cewa zasu kara yiwuwar bayyanar cututtuka (wanda aka sani da suna flares ).
Cutar
Dukkan cututtuka da kuma ciwon daji na iya jawo cutar bayyanar psoriasis. Mun ga wannan musamman tare da kwayar cutar HIV , wani cuta mai ciwo da ke hade da ci gaba da ƙonewa. Duk da yake yawan psoriasis yafi ko kuma ƙasa da yawan jama'a, mummunan cutar ya fi muni yayin da HIV ke shiga.
Kuskuren cirewa ya zama babban abu, ko cutar ta HIV ne ko kamuwa da cuta mai kama da mashako, strep makogwaro, ko mura.
Ya bambanta, yin maganin kamuwa da cuta zai iya sauƙaƙe saurin bayyanar cututtuka. Nazarin ya nuna, alal misali, cewa kwayoyin magunguna na iya rage yawan yawan psoriasis a cikin mutanen dake fama da cututtukan zuciya. Haka kuma ya zama gaskiya a lokacin da ake amfani da kwayoyi masu cutar antiretroviral a cikin mutanen da ke dauke da kwayar cutar HIV.
Skin Trauma
Har ila yau cututtukan fata na iya haifar da alamun psoriasis bayyanar cututtuka, wanda ake kira "Koebner" . Wannan amsa kuma ana gani tare da wasu yanayi kamar warts, lichen planus , da molluscum contagiosum .
Kamar yadda daya daga cikin mutane hudu tare da psoriasis sun fuskanci wannan, an haifar da komai daga sunburns da kwari na kwari zuwa ƙwayar fata da kuma gurasar allura. Koda magungunan fata na tsofaffi, irin su rauni ko tattoo, zai iya zama tushen farko na furofikan psoriasis.
Magunguna
Wasu magunguna an san su don faɗakar da cututtukan psoriasis. Ba su shafi dukan mutane a cikin hanyar kuma bazai haifar da bayyanar cututtuka ba. Duk da haka, magungunan da aka fi ambata sun hada da:
- Lithium
- Beta-blockers
- Magungunan anti-inflammatory marasa nau'in ƙwayoyin cuta (NSAIDs)
- Anti-malaria da kwayoyi
- Calcium tashar blockers
- Magunguna masu lalata maganin Lipid
Bugu da ƙari, ƙaddamar da ƙwayoyin corticosteroids na yau da kullum da ake amfani da shi don bi da psoriasis na iya samun tasirin "rebound" da kuma haifar da mummunan haske. Saboda wannan dalili, kamata a koyaushe kullun kwakwalwa a hankali, a karkashin jagorancin likita, idan ba a buƙatar magani ba.
Matsayin Kwayoyin Yanayin Rayuwa
Bisa ga yanayin da ake fuskanta game da hadarin rayuwa, akwai uku da suke da alaƙa da alamar psoriasis: damuwa, shan taba, da kiba.
Damuwa
Ƙwarewa yana da dangantaka da haɗari ga psoriasis. A gefe guda, damuwa zai iya haifar da bayyanar cututtuka, yayin da, wasu ɗayan, alamar cututtuka na iya jawo damuwa.
Kamar yadda jiki ke aika sakonni masu baƙar fata don warkar da rauni, damuwa na tunanin mutum zai iya haifar da amsa mai zafi wanda yana da tasiri mai banƙyama, yana damuwa maimakon inganta yanayin.
Wannan shi ne musamman damuwa tun lokacin da ake yin psoriasis yana haɗuwa da ƙananan juyayi da damuwa. A wasu lokuta, za a iya kakkarya zagayowar mugun abu tare da maganin lafiya daidai, ciki har da psychotherapy da kuma dace da amfani da maganin antidepressant ko maganin rikici.
Shan taba
Binciken da aka yi kwanan nan sun nuna cewa mutanen da suke shan taba fiye da fakitin cigaba a kowace rana sunyi sau biyu suna iya samun psoriasis mai tsanani fiye da wadanda ke shan taba siga 10 ko ƙasa da kullum.
Masana kimiyya basu tabbatar da dalilin da yasa wannan ba amma gaskanta cewa shan taba yana iya ƙara yawan autoantigens a cikin matsanancin layin fata (wanda aka sani da epidermis ). Wadannan sunadarai ne cewa tsarin rigakafi na kai hari don kai harin kai tsaye. Wasu sun nuna cewa shan taba yana motsawa ko kuma ta hanzarta amsawar da aka yi.
Haka kuma bincike ya kammala cewa matan da suke shan taba suna da hatsari mai tsanani na psoriasis fiye da maza. Yawan shekarun da mutum yayi kyafaffen yana taimakawa.
Kiba
Abune yakan iya haifar da samuwa a cikin launi na fata. Duk da yake ainihin dalilin wannan ba shi da kyau, bincike ya nuna cewa yawancin kima ya ƙãra yawan samar da sunadaran ƙwayoyin cuta mai suna cytokines . Cytokines ba wai kawai ƙara yawan ƙonewa ba, yana sa alamun bayyanar ya fi mummunan rauni, amma inganta cigaba da kafa kamfunan a wuraren da babban kundin kaya (watau fata).
Ƙungiyar ta ƙara tabbatarwa ta hanyar dangantaka tsakanin kiba, ciwon sukari, da kuma psoriasis. Ganin cewa ƙudan zuma zai iya shawo kan cutar mutum 2 irin na ciwon sukari , ciwon sukari zai iya kara yawan hadarin da kuma yawan nau'in psoriasis na plaque da kashi 27 cikin 100.
> Sources:
> Arias-Santiago, S .; Espiñeira-Caimo, M .; da Aneiros- Fernández, J. "The Koebner Phenomenon: Psoriasis a Tattoos." CMAJ . 2013 Apr 16; 185 (7): 585. PMCID: PMC3626811.
> Armstrong, A ;; Harskamp, C. da kuma Armstrong, E. "Ƙungiyar ta tsakanin Psoriasis da Obesity wani Tarihin Bincike da Meta-Analysis na Nazarin Nazari." Ciwon sukari Nutr. 2012 Dec 3; 2: e54. DOI: 10.1038 / nutd.2012.26.
> Armstrong, A ;; Harskamp, C. Dhillon, J. et al. "Psoriasis da shan taba: A Review System da Meta-Analysis." Br J Dermatol . 2014 Feb 170 (2): 304-14. DOI: 10.1111 / bjd.12670.
> Jankovic, S .; Raznatovic, M .; Marinkovic, J. et al. "Ayyukan Risk don Psoriasis: Nazarin Jirgin Lafiya". J Dermatol. 2009 Yuni; 36 (6): 328-34. DOI: 10.1111 / j.1346-8138.2009.00648.x.
> Mosiewicz, J; Pietrzak, A .; Chodorowska, G et al. "Rational for statin amfani a marasa lafiya psoriatic." Arch Dermatol Res . 2013 Aug 305 (6): 467-72. DOI: 10.1007 / s00403-013-1374-1.