Ayyukan Genetics ba duka sananne ba a cikin iyalan da aka shafi
Kwayoyin halitta suna iya taka muhimmiyar rawa a kowane nau'i na cututtukan Parkinson . Duk da haka, yayin da cike da haɗuwa da kwayoyin halitta na iya ƙara yawan haɗarin cutar, ba dole ba ne cewa za ku samu.
Kimanin kashi 15 zuwa 25 cikin dari na mutanen da ke zaune tare da Parkinson suna da tarihin iyali na yanayin, ko dai wani halayen dan lokaci ko na biyu.
Samun daya ko fiye daga cikin waɗannan dangi zai sanya ka a cikin dan kadan mafi haɗari ga Parkinson, amma har yanzu babu tabbacin cewa za ku ci gaba da cutar.
A wata hanya, idan kana da Parkinson, kada ya bayar da shawarar cewa kowane daga cikin yara ko jikokinka zai sami cutar ko dai. Wannan kawai yana nuna cewa haɗarinsu ya zama dan kadan fiye da wadanda ba tare da tarihin iyali ba.
A ƙarshe, mafi yawan lokuta na Parkinson ba su da wata sanarwa (wanda muke magana a kai ko dai yana da ciwon cututtuka ko rashin lafiya). Duk da yake akwai siffofi da suka yi kama da iyalansu, waɗannan asusun na karamin yawan lokuta - kimanin kashi biyar zuwa 10, duk sun fada.
Abubuwan Gudanar da Ƙungiyar Manyan Lambobin da Suka Haɗu da Parkinson
Akwai siffofin kwayar cutar Parkinson da ke nuna cewa cutar ta haifar da iyalan cikin iyali. Mun yi la'akari da wannan tare da irin wadannan cututtuka na farko da cutar ta nuna cewa alamu suna nunawa a baya fiye da matsakaicin shekaru 60 .
Wani nau'i na maye gurbin kwayar halitta da ke da dangantaka da iyali Parkinsonism yana cikin abin da ake kira SNCA . Wannan shi ne jinsi da aka hade tare da samar da furotin na alpha-synuclein, wani kwayar halitta wanda zai iya taimakawa wajen maganganu a cikin kwayoyin jikinsu. Yayinda yake da yawa a cikin yawancin jama'a, an gano magungunan SNCA a kusan rabin kashi na iyalan da Parkinson ya shafa.
A shekara ta 2004, masana kimiyya sun gano irin wannan maye gurbin kwayar halitta a cikin wasu iyalai da dama wadanda aka mamaye mambobi. Abin da ake kira LRRK2 maye gurbin yau yana danganta da kimanin kashi ɗaya zuwa kashi biyu cikin dukkan lokuttan Parkinson, mafi yawancin mutanen da suka shafi Yahudawa, Ashkenazi, Arewacin Afrika Arab-Berber, ko asalin Basque.
Wani maye gurbin da ke dauke da jigidar GBA an riga an san shi don ya cutar da cutar Gaucher (rashin lafiyar jiki wanda ke tattare da raunuka, gajiya, anemia, da kuma hawan hanta da kuma yada). Binciken ya nuna cewa maye gurbi na GBA ya kasance a cikin mutane masu yawa tare da Parkinson, yana bada shawara game da haɗin kai tsakanin maye gurbin da cutar.
Gidajen Yanayi da Muhalli
Hanyoyin muhalli sune mahimmanci masu bayar da gudummawa ga cigaban Parkinson kuma yana iya, a wasu lokuta, aiki tare da kwayoyin halitta don haifar da rashin lafiya . Wani bincike a shekara ta 2004 ya nuna cewa mutanen da suka canza kwayar cutar CYP2D6 kuma sun kamu da kwayar cutar magungunan magungunan magungunan magungunan magungunan magungunan magungunan magunguna sun kasance sau biyu.
A kan kansu, magungunan kashe qwari, ƙwayoyin mota, magunguna, da sauran masu maye gurbin sun hada da Parkinson. Amma abinda ke da ban sha'awa shi ne cewa wadanda basu da maye gurbin CYB2D6 kuma ba a bayyana su ga magungunan kashe qwari ba su samuwa a kowane mummunar haɗari na bunkasa yanayin.
Kalma Daga
Kodayake ba ku da wani amfani a kai a yanzu, sakamakon gwajin kwayoyin zai iya taimakawa wajen binciken binciken Parkinson ta hanyar barin masana kimiyya su fahimci cutar da kuma inganta sababbin jiyya. Yayin da zaba don gwaji shi ne na sirri, yana iya amfani idan mahalarta mahalarta sun shafi ko kuma idan kana cikin haɗari mai zurfi bisa ga kabilan ka.
Sources:
> Lesage, S. da Brice, A. "Ciwon kwayar cutar Parkinson: daga monogenic ya haifar da abubuwan da suka shafi kwayoyin halitta.". Jinsin Halittar Mutum . 2009; 18 (R1): R48-59.
> Stewart, A .; Factor, D. William J. et al. Kwayar Parkinson: Ciwon Bincike da Gudanar da Harkokin Clinical (2nd edition). New York: Ƙwararrun Magunguna na Demos; 2008; ISBN-10: 1933864001.