Har yanzu yana da wuri da za a fada, amma al'ada mai ban sha'awa yana iya zama a sarari
Nazarin Kanada wanda aka wallafa a New England Journal of Medicine ya nuna cewa mutanen da ke fama da ƙwayar ƙwayar cuta zuwa ƙananan sclerosis (wanda ake kira CIS) wanda ke daukar maganin maganin maganin kwayoyin cutar na iya zama ƙananan haɗari na bunkasa ƙwayar sclerosis.
Tabbas, akwai babban kira ga shan minocycline a matsayin farfadowa ga CIS, saboda yana da sauki, mai sauƙin ɗaukar (yana da maganin maganin maganganu), kuma yana da kyakkyawan bayanin haɗin mai kyau.
Duk da haka, ta yaya ya kwatanta da sauran magunguna kamar Betaseron ko Avonex? Bugu da ƙari, binciken da ya nuna tasirinsa ƙananan ne, saboda haka ana bukatar ƙananan gwaji don tabbatar da amfaninta.
Bari mu dubi wannan farfadowa mai yiwuwa. Ko da yake yana iya ko a'a ba ya aiki, fahimtar "me yasa" a baya yadda kwayoyin cutar zasu iya hana ci gaban MS yana da ban sha'awa a kansa.
Minocycline a matsayin Magani na Jiyya ga CIS
Kafin kayi nazarin binciken bayan minocycline a matsayin maganin CIS, yana da mahimmanci don gane abin da ciwo mai cututtuka ga MS shine, da kuma yadda za'a iya la'akari da minocycline a matsayin farfadowa.
Mene Ne Ciwon Cutar Abun Ciki Ciki?
Ciwo na rashin lafiya na ƙwayar cuta zuwa ƙwararrun sclerosis, ko CIS, yana nufin mutanen da suka fuskanci alamar "MS-like" don akalla sa'o'i 24, kuma waɗannan bayyanar cututtuka na iya zama ko kuma ba su haɗu da raunuka da aka gani a MRI ba.
Kicker shi ne cewa banda wannan labarin farko, babu wasu alamomi cewa mutum yana da sifofin MS na baya , ko dai ta wurin tarihin su ko kuma ta MRI (babu wasu lahani na kwakwalwar MS).
A wasu kalmomi, mutum ba shi da isasshen asibiti ko kuma bayanan rediyo don samun ganewar asali na MS.
Wani kalubale tare da bincikar CIS shine cewa likita dole ne tabbatar da cewa "alamun" MS-like "alal misali (alal misali, fata neuritis ) hakika saboda hasara na myelin-murfin kare kan jikin kwayoyin kwakwalwa da kwakwalwa.
Wannan na iya buƙatar ƙarin gwaji kamar lafaɗar lumbar ko ƙwayar cuta , da kuma fitar da wasu yanayin MS-mimicking kamar kamuwa da cuta ko wasu cututtuka na autoimmune (alal misali, lupus erythematosus).
Wannan shi ne inda abubuwa zasu iya zama masu tasowa, kamar yadda mai ilimin lissafin jiki ya yi amfani da hukuncinsa don sanin ko mutumin da ke fama da rashin lafiya a asibiti zuwa MS ya kamata ya jiyya tare da maganin cututtukan cututtuka.
Yawancin lokaci, ana bada magani idan mutum da CIS yana da MRI wanda ya nuna jabu da aka gani a cikin MS.
Menene Minocycline?
Minocycline kwayar halitta ce, saboda haka yana da magani da ake amfani dashi don hana ci gaban kwayoyin cuta. An yi amfani da shi don biyan yanayin likita kamar ƙwayar cuta, ko huhu, jima'i, da cututtukan fata.
Kuna iya yin mamakin yadda yin amfani da minocycline zai iya amfanar da wani mai hadari don bunkasa MS. Da kyau, masana kimiyya sun sami minocycline don samun kariya masu kariya, don haka zai iya kwantar da hankalin mutum na rigakafi, baya ga hana rigakafin kwayoyin cuta.
Yana yiwuwa yiwuwar kayan ƙwayar magunguna na minocycline ta fito ne daga ikon iya canza kwayoyin a cikin ƙuƙwalwar mutum tun lokacin da wadannan kwayoyin suna taka muhimmiyar rawa wajen tsara tsarin rigakafin mutum.
Har ila yau, an yi amfani da Minocycline don hana ƙaura daga wasu kwayoyin halittar da ke kaiwa mai kwakwalwa a cikin kwakwalwa da kashin baya.
A ƙarshe, bincike ya nuna cewa minocycline zai iya kare kwayoyin cutar ta hanyar hana mutuwa. Wannan wata hanya ce wadda zata iya amfani da wadanda ke da CIS.
Menene Nazarin Ya Bayyana?
A cikin shekaru 4, an haɗu da 142 mahalarta tare da CIS daga kamfanoni na Kanada 12 daban-daban na Kanada don karɓar ko wane 100mg na minocycline sau biyu a rana ko wuribo.
Dukan masu halartar taron sun fara samun alamun bayyanar CIS a cikin kwanaki 180 kafin fara karatun. Yawancin masu halartar sun kasance mata (kashi 68), kuma wannan shi ne al'ada na CIS (yana da yawa a cikin mata), tare da shekarun shekaru kusan 36.
Binciken ya zama makafi biyu, ma'ana mahalarta ko masu binciken sun san ko suna samun minocycline ko placebo.
Mahalarta sun ci gaba da shan shan magani (ko placebo) har sai dai an gano su tare da MS ko kuma har zuwa watanni 24 bayan sun fara shan minocycline (ko placebo).
Sakamakon ya nuna cewa a cikin watanni 6 bayan mahalarta suka fara amfani da minocycline, kashi 33 cikin dari na ci gaba da MS, idan aka kwatanta da kashi 61 cikin dari na masu halartar taron. Wannan wani bambanci ne na kusan kashi 28 cikin dari.
Bayan daidaitawa ga yawan marasa lafiya na MS, bambanci ya sauko zuwa kashi 18.5 cikin dari, wanda har yanzu yana da tilasta. Dalilin wannan gyare-gyaren shi ne cewa an daidaita sharudda don bincikar MS a yayin wannan binciken. Bisa ga ka'idodin McDonald na 2010, za'a iya gano mutum tare da MS idan suna da shaida ta MRI na cutar ta MS, ko da sun kasance basu da alamar cututtuka da suka danganci waɗannan raunuka.
Duk da yake hadarin canzawa daga CIS zuwa MS ya kasance da muhimmanci ƙwarai a cikin waɗanda suka dauki minocycline a watanni 6 idan aka kwatanta da placebo, da rashin alheri, wannan ba a ci gaba ba a watanni 24.
Ta yaya Minocycline yayi kwatanta da sauran hanyoyin kwalliyar CIS?
Sakamakon wannan binciken yana kama da sauran maganin da aka yi amfani da CIS kamar Betaseron (interferon beta-1b), Avonex (interferon beta-1a), da Aubagio (teriflunomide), ma'anar a watanni 6, waɗannan maganin cutar sun nuna irin wannan ƙananan kasada ga bunkasa MS.
Duk da haka, babu wani shugaban da zai fara gwajin gwajin minocycline zuwa ɗaya daga cikin hanyoyin kwantar da hankali, don haka yana da wuri da wuri don gaya yadda yake kwatanta shi.
Dukkanin, yayin da minocycline yana da kyau a matsayin magani maras tsada da lafiya, binciken da yayi la'akari da amfaninta a matsayin magunguna ga CIS ƙananan kuma yana da wasu ƙuntataccen bincike.
Ana buƙatar ci gaba da karatu don ganin wannan yana da kyau sosai kuma yana da mahimmanci magani.
Shin Akwai Downside zuwa Takama Minocycline?
Kuna iya yin mamaki idan akwai matsala don ɗaukar minocycline, kamar dai yana da lafiya ko rashin rashin lafiya. Wannan yana da mahimmanci saboda cike da magani sau biyu a rana yana iya ƙalubalanci ƙalubalen, kuma idan ya sa ka ji daɗi, wannan adadin ya zama mawuyaci.
Abubuwan da zasu iya faruwa tare da minocycline sun hada da:
- Diarrhea
- Dizziness ko lightheadedness
- Ciwon kai
- Dental discoloration (kamar graying na hakora da baki)
- Sensitivity zuwa rana (za ka iya samun muni fiye da al'ada kunar rana a jiki)
- Fungal cututtuka (alal misali, cike da yisti yisti)
Haka kuma akwai wasu matsaloli masu wuya amma masu tsanani waɗanda zasu iya faruwa tare da minocycline kamar nau'in gwargwadon pseudotumor . Bugu da ƙari, ana amfani da minocycline a cikin ciki da kuma rayarwa, kuma zai iya rage tasirin kwayoyin haihuwa.
Duk da haka, duk da waɗannan cututtukan da aka ambata, minocycline yana da cikakkiyar bayanin tsare mai kyau kuma mutane suna da kyau tare da shi.
Tabbas, kamar kowane magani, kana buƙatar yin magana da likitanka da kyau game da hadarin da ke ɗaukar minocycline tare da amfaninta (idan an yarda da shi don amfani a CIS), da kuma duba dukan tasirinsa na illa.
Kalma Daga
Duk da yake sakamakon wannan binciken na musamman yana da ban sha'awa, shine kawai jariri a cikin jagorancin hani na hana MS daga faruwa a cikin mutanen da aka gano tare da bayyanar cututtuka. Ana buƙatar ƙarin karatu a kan minocycline, musamman a yayin da bincike ke ci gaba da haɗuwa akan sakamakon.
Alal misali, binciken daya ya nuna minocycline da aka ba da Beta-Seron bai inganta kula da cutar ba a cikin mutane tare da sake dawowa-yad da yawa na sclerosis. Wannan rikice-rikice ne kawai ya nuna cewa karin bincike ya kamata a yi kafin masana kimiyya su fara ba marasa lafiya da kwayoyin cutar kwayar tetracycline.
> Sources:
> Marcus JF, Waubant EL. Ɗaukaka a kan ciwo na asibiti da kuma tsarin bincike don ƙwayar sclerosis. Neurohospitalist . 2013 Afrilu 3 (2): 65-80.
> Metz LM et al. Jaraba na minocycline a cikin ƙwayar cututtuka na asibiti na sclerosis mai yawa. N Eng J Med. 2017 Jun 1; 376 (22): 2122-33.
> Ƙungiyar Sclerosis ta Kanada. (Mayu 2017). Minocycline for Clinically Crisis Syndrome (CIS) FAQ.
> Sørensen PS et al. Minocycline ya kara wa β-1a interferon a cikin ƙananan sclerosis: binciken RECYCLINE bazuwar. Eur J Neurol. 2016 May; 23 (5): 861-70.