Wannan gwajin ya gano autoantibodies wanda zai taimaka tabbatar da ganewar asali
An yi amfani da gwajin anti-CCP don gano kwayoyin halitta da kuma taimakawa wajen rarrabe tsakanin cututtukan cututtukan zuciya da sauran cututtukan cututtuka . Cikakken peptide (CCP) wanda aka yi amfani da shi na cyclic ya kasance mai tsauri ne a kan sunadarin sunadarai (ACPA) kuma an auna shi ta wannan gwaji.
Jarabawar tana da matukar mahimmanci ga ƙwararrun maganin arthritis , a cikin rahoto tsakanin 50 zuwa 75 bisa dari.
Har ila yau, yana da cikakkiyar mahimmanci ga ƙwayar arthritis na rheumatoid na kimanin kashi 90. Babban halayensa shi ne dalilin da yasa gwajin anti-CCP ya zama wani muhimmin ɓangare na tsarin bincike don cutar arthritis.
Cikakken gwajin Anti-CCP da Gaskiya Dama
Bayan taimakawa wajen rarrabe tsakanin cututtukan cututtuka na ƙwayoyin cuta , gwajin anti-CCP yana da mahimmanci wajen bincikar mutanen da ke da matsala ga matsalar rheumatoid . Ba wai kawai jarrabawar anti-CCP ta gano darajar (ƙayyade wane yanayin da kake da) ba, yana da darajar ganewa (tsinkaya yanayin da kake ciki).
Idan anti-CCP ya kasance a matsayi na matsakaici, ba kawai yana taimakawa wajen tabbatar da ganewar asali ba, yana nuna cewa akwai yiwuwar zama wata hanya ta cututtuka kuma mai tsanani, kamar lalacewa ta haɗuwa. Ƙananan matakan antibody ba kamar yadda yake ba ne ko tsinkaya.
Yawancin lokaci ana gwajin gwajin anti-CCP tare da gwajin gwagwarmaya, tun da babu gwajin kadai zai iya tabbatar da ganewar asali na rheumatoid arthritis.
Bisa ga masanin ilimin lissafi Scott J. Zashin, "Yayinda matsalar mahaukaci yafi kowa a cikin mutanen da ke fama da cutar wariyar launin fata, akwai mutanen da ke da tabbacin gamsar da kwayar cutar da ba su da ciwon maganin ƙwayar cuta. Har ila yau, kasancewar matsalar rheumatoid yana da mahimmancin mahimmanci fiye da ACPA.
Har ila yau, idan mutum yana da mummunar mummunar matsalar, to, sun kasance mafi mahimmanci ga ACPA. "
Gano Bayanan Tsaro
Muhimmancin gano magunguna a cikin cututtuka na rheumatic an gano shekaru da yawa, amma gano wadanda ke da asali a cikin asibiti da ke da ƙayyadaddun hankali da kuma karfin zuciya sun dauki lokaci. Akwai gwagwarmaya uku na gwajin anti-CCP. Tare da kowace ƙarni na gwaji da ƙayyadadden bayanai da haɓakawa sun inganta.
A cewar "Kelley's Textbook of Rheumatology," fiye da kashi 90 cikin mutanen da ke dauke da cututtuka marasa lafiya wanda basu gwadawa ba wanda ya gwada gwaji ga anti-CCP ya haifar da arthritis na rheumatoid cikin shekaru uku. Kusan kashi 25 cikin dari na wadanda ke dauke da cututtukan da ba su damu ba wadanda suke gwada gwaji don anti-CCP suna bunkasa maganin arthritis na rheumatoid.
Za'a iya gano kwayoyin cutar ta atomatik kafin ingancin asibiti na wasu cututtukan cututtuka, ciki har da arthritis na rheumatoid. Tsarin maganin safarar kwayar cutar zai iya zama farkon fararen maganin arthritis na rheumatoid na shekaru biyu zuwa shida, bisa ga "Kelley's Textbook of Rheumatology." An bayar da rahoton cewa, anti-CCP da ke gabanta, ganewar asalin maganin arthritis, sau biyu ne, kamar yadda aka gano magungunan rheumatoid dake gabanin ganewar asali.
Yayinda yawancin rheumatoid yakan kasance a halin yanzu, kasancewar anti-CCP na iya bambanta a cikin marasa lafiya na arthritis - har ma da bace a wasu lokuta.
Muhimmancin Anti-CCP
Masu bincike suna ci gaba da kallon abin da yake faruwa a jiki don samar da kwayoyin (antigens) wanda ke haifar da samar da wadannan kwayoyin anti-CCP. An kira su autoantigens saboda an samar da su ta hanyar raguwa daga cikin kayan jiki a cikin jiki maimakon zuwa daga waje na jiki. Peptidylarginine deiminase (PAD) enzymes, wanda ke haifar da canzawar peptidylarginine zuwa peptidylcitrulline, yana da muhimmiyar rawa wajen samar da autoantigens a cikin rheumatoid arthritis.
Har ila yau, ana buƙatar ƙarin bincike don sanin abin da ke haifar da lokacin da ake nunawa na jini na rheumatoid arthritis don matsawa cikin wata alama ta hanyar cututtuka.
Duk da yake anti-CCP yana da mahimmanci ga ƙwayoyin cututtuka na rheumatoid, sakamakon sakamako mai kyau zai iya faruwa tare da wasu cututtuka na rheumatic auto-immune, tarin fuka, da kuma cutar huhu. An riga an ruwaito kwayoyin cutar anti-CCP a cikin launi na lupus erythematosus da kuma ciwon sifogren na farko, yawanci lokacin da ciwon arthritis ya kasance. An samo shi har zuwa kashi 16 cikin dari na mutanen da ke dauke da maganin arthritis - musamman sau da yawa tare da furotin ko polyarthritis . Wani lokaci, yana tare da psoriasis mai tsanani ba tare da cututtuka ba.
> Sources:
> Cush JJ, Kavanaugh A, Weinblatt ME. Arthritis Rheumatoid: Sanin asali da Jiyya . West Islip, NY: Sadarwar Kasuwancin; 2010.
> Firestein GS, Kelley WN. Kelleys Textbook na Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Taylor PC, Maini RN. Masana Ilimin Halittu a cikin Sanin Asali da Bincike na Arthritis Rheumatoid. Na zamani. https://www.uptodate.com/contents/biologic-markers-in-the-diagnosis-and-assessment-of-rheumatoid-arthritis.